Sat.Jun 22, 2024 - Fri.Jun 28, 2024

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These microscopic tunnels are a goldmine for new medicines

BioPharma Drive: Drug Pricing

A growing cohort of biotechs, from Biohaven to Neurocrine to Jazz, hope research on ion channels will bring them new drugs and big business — much like it has done for Vertex.

Research 345
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We date, marry people who are attractive as we are, new analysis finds

Science Daily: Pharmacology News

Men and women were good at judging their own attractiveness, and tended to partner up with people who were similarly attractive.

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CDC Advises Updated COVID Vaccine for Everyone Over 6 Months of Age

Drugs.com

FRIDAY, June 28, 2024 -- As a summer wave of COVID infections rolls across the country, U.S. health officials have recommended that all Americans over the age of 6 months get one of the updated COVID vaccines when they become available this.

Vaccine 312
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Vault Snack #24 - New Interface, Features & Infrastructure for the CDD Vault ELN

Collaborative Drug

Vault Snack #24 - New Interface, Features & Infrastructure for the CDD Vault ELN

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Women with a common hormonal disorder have few good treatment options. Could GLP-1 drugs help?

BioPharma Drive: Drug Pricing

Obesity drugs like Wegovy are proving useful in many other diseases. Polycystic ovary syndrome, a chronic condition that can cause infertility, may be one.

Treatment 313

More Trending

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Migraine Prevention Med, Quilipta, Might Stop 'Rebound' Headaches, Too

Drugs.com

THURSDAY, June 27, 2024 -- It's a nasty cycle: Chronic migraine sufferers who use too much pain medication sometimes get smacked with rebound headaches. But new research suggests that a medication commonly used to prevent migraines may also help.

Research 278
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CDD Vault Update (June 2024 #2)

Collaborative Drug

Learn about the latest update in CDD Vault's Sample Management feature, allowing you to track samples, manage inventory, and create hierarchies of locations. Find out how to create, edit, and delete samples and events, and get helpful hints for managing multiple samples. Discover how to import assay data and maintain compatibility with legacy batch-level inventory features.

Drugs 261
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Exsilio debuts with $82M, pitching a ‘leap’ forward for genetic medicine

BioPharma Drive: Drug Pricing

The company claims it can address some of the field’s limitations with medicines delivered via messenger RNA and lipid nanoparticles.

RNA 293
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Tiny bright objects discovered at dawn of universe baffle scientists

Science Daily: Pharmacology News

A recent discovery by NASA's James Webb Space Telescope (JWST) confirmed that luminous, very red objects previously detected in the early universe upend conventional thinking about the origins and evolution of galaxies and their supermassive black holes.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Cholesterol Med, Fenofibrate, Might Slow Vision Loss in People With Diabetes

Drugs.com

TUESDAY, June 25, 2024 -- A well-established cholesterol-lowering drug appears to significantly slow the progression of a diabetes-related eye disease, a new trial shows. Fenofibrate (Tricor) has been approved since 2004 as a means of lowering.

Trials 279
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Gut microbiome changes align with increased risk of type 2 diabetes

Broad Institute

Gut microbiome changes align with increased risk of type 2 diabetes By Tom Ulrich June 25, 2024 Breadcrumb Home Gut microbiome changes align with increased risk of type 2 diabetes Specific species and strains of bacteria linked to changes in the functioning of the gut microbiome and a person's risk of type 2 diabetes By Jennifer Welsh, Brigham and Women's Hospital June 25, 2024 Credit: Donny Bliss, NIH Illustration depicting gut bacteria.

Virus 135
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First-of-its-kind Intellia data suggest CRISPR drug could be given more than once

BioPharma Drive: Drug Pricing

The findings provide early proof that multiple doses of a gene editing medicine can be safely administered with additive effects, overcoming a key constraint of the complex therapies.

Therapies 284
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First case of Down syndrome in Neanderthals documented in new study

Science Daily: Pharmacology News

A new study documents the first case of Down syndrome in Neanderthals and reveals that they were capable of providing altruistic care and support for a vulnerable member of their social group.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Slow-Release Ketamine Pill Eases Depression: Study

Drugs.com

TUESDAY, June 25, 2024 -- A new slow-release pill form of ketamine can quell hard-to-treat depression without producing psychedelic side effects normally associated with the drug, early research suggests. Patients on the strongest dose of ketamine.

Research 279
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Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1

Covalent Modifiers

Jianfeng Lou, Qianqian Zhou, Xilin Lyu, Xinyi Cen, Chen Liu, Ziqin Yan, Yan Li, Haotian Tang, Qiupei Liu, Jian Ding, Ye Lu, He Huang, Hua Xie, and Yujun Zhao Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.4c00291 Clinical and biological studies have shown that overexpression of BFL-1 is one contributing factor to venetoclax resistance.

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2seventy slims down with sale of hemophilia assets to Novo

BioPharma Drive: Drug Pricing

Novo will pay $38 million in cash under the deal, which will also see 2seventy employees working on the program transfer to the Danish drugmaker.

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Microrobot-packed pill shows promise for treating inflammatory bowel disease in mice

Science Daily: Pharmacology News

Engineers have developed a pill that releases microscopic robots, or microrobots, into the colon to treat inflammatory bowel disease (IBD). The experimental treatment, given orally, has shown success in mice. It significantly reduced IBD symptoms and promoted the healing of damaged colon tissue without causing toxic side effects.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Twice-a-Year Injection Gives Women Full Protection Against HIV, Trial Finds

Drugs.com

MONDAY, June 24, 2024 -- Just two injections a year of a new HIV drug protected young women in Africa from infection with the sexually transmitted disease, new trial results show.In announcing the findings, Gilead Sciences Inc. said its HIV.

Trials 279
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Covalent Modifiers - Untitled Article

Covalent Modifiers

Nickolas J. Serniuck, Eden Kapcan, Duane Moogk, Allyson E. Moore, Benjamin P.M. Lake, Galina Denisova, Joanne A. Hammill, Jonathan L. Bramson, Anthony F. Rullo, Molecular Therapy: Oncology , 2024 , 200842, [link] Proximity-induction of cell-cell interactions via small molecules represents an emerging field in basic and translational sciences. Covalent anchoring of these small molecules represents a useful chemical strategy to enforce proximity, however it remains largely unexplored for driving c

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Supreme Court overturns Chevron doctrine, limiting reach of federal agencies

BioPharma Drive: Drug Pricing

Federal courts will no longer have to defer to agency regulations for interpretation of ambiguous statutes, a ruling that could have significant impact on the FDA and CMS.

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Carbon dioxide's heavy stamp on temperature: Doubling CO2 may mean 7 to 14 degree increase

Science Daily: Pharmacology News

A doubling of the amount of CO2 in the atmosphere could cause an increase in the average temperature on earth from 7 to even a maximum of 14 degrees. That is shown in the analysis of sediments from the Pacific Ocean off the coast of California.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Supreme Court Rejects Purdue Pharma Opioid Settlement

Drugs.com

FRIDAY, June 28, 2024 -- The U.S. Supreme Court on Thursday struck down a controversial settlement that drug maker Purdue Pharma had reached with victims of the opioid epidemic.The ruling threatens a massive bankruptcy plan that would have.

Drugs 264
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Hero, Villain, or Victim? Stories that Sabotage

Perficient: Drug Development

In 1968, psychiatrist Stephen Karpman modeled what he called the Drama Triangle. With this, he illustrated dysfunctional mindsets that can derail social interactions. The three roles defined in this model are the rescuer (hero), persecutor (villain), and victim. This is another view of the lies we tell ourselves. Since the dawn of history, we’ve loved stories.

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Novo nixes trial of blood pressure drug it bought in deal worth $1.3B

BioPharma Drive: Drug Pricing

The failure of a Phase 3 trial led the Wegovy maker to take an accounting charge that will hit its operating profit growth this year.

Trials 242
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Creating supranormal hearing in mice

Science Daily: Pharmacology News

A new study has produced supranormal hearing in mice, while also supporting a hypothesis on the cause of hidden hearing loss in people.

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Combo Drug, Kadcyla, Boosts Survival in Some Women With Early Breast Cancer

Drugs.com

FRIDAY, June 28, 20204 (HealthDay news) -- An immunotherapy/chemotherapy combo drug can help early-stage breast cancer patients remain cancer-free following treatment, a new trial shows. The combo drug, Kadcyla, is already approved to treat.

Drugs 264
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Best Practices for Drug Patent Portfolio Management

Drug Patent Watch

Introduction Patent portfolios are critical assets for pharmaceutical companies, providing market exclusivity and protecting revenue streams for drug products. Effective management of drug patent portfolios requires strategic planning, ongoing evaluation, and adaptation to the evolving pharmaceutical landscape. This article explores key best practices for optimizing drug patent portfolios to maximize value and maintain competitive advantage.

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AbbVie expands its IBD prospects with $250M Celsius deal

BioPharma Drive: Drug Pricing

The pharma’s acquisition of Celsius is the latest in a string of deals by major drugmakers hunting anti-inflammatory medicines.

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Non-stop flight: 4,200 km transatlantic flight of the Painted Lady butterfly mapped

Science Daily: Pharmacology News

In October 2013 a researcher made a surprising discovery of Painted Lady Butterflies on the Atlantic beaches of French Guiana -- a species not typically found in South America. This unusual sighting prompted an international study to investigate the origin of these butterflies.