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FDA Approves Prefilled Syringe Presentation for Shingles Vaccine

Drugs.com

Food and Drug Administration has approved a prefilled syringe presentation of Shingrix (zoster vaccine recombinant, adjuvanted) for the prevention of shingles (herpes zoster). MONDAY, July 21, 2025 -- The U.S. The existing vaccine consists of two.

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Three-person DNA IVF stops inherited disease—eight healthy babies born in UK first

Science Daily: Pharmacology News

The early results are highly promising: all the babies are developing normally, and the disease-causing mutations are undetectable or present at levels too low to cause harm. The process, known as pronuclear transfer, was designed to prevent the inheritance of devastating mitochondrial diseases passed down through the mother’s DNA.

DNA
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Site-Specific Molecular Glues for the 14-3-3/Tau pS214 ProteinProtein Interaction via Reversible Covalent Imine Tethering

Covalent Modifiers

This work presents the identification and early-stage optimization of small molecule fragment-like stabilizers for a specific binding site of the 14-3-3/Tau PPI.

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Methods for Kinetic Evaluation of Reversible Covalent Inhibitors from Time-Dependent IC50 Data

Covalent Modifiers

Herein, we present an implicit equation that can estimate these constants from incubation time-dependent IC50 values and a numerical modelling method, EPIC-CoRe, that can fit these kinetic parameters from pre-incubation time-dependent IC50 data.

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Researchers devise new way to target and correct disease-related proteins

Broad Institute

These compounds bring together two proteins in the cell that might not normally find each other a target protein (often the one altered in disease), and a presenter protein that has some effect on the target. For their presenter protein, they chose FKBP12, a well-studied protein that is abundant in human cells.

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Models show intensifying wildfires in a warming world due to changes in vegetation and humidity; only a minor role for lightning

Science Daily: Pharmacology News

Climate scientists present a realistic supercomputer simulation that resolves the complex interactions between fire, vegetation, smoke and the atmosphere. The authors find that increasing greenhouse gas emissions will likely increase the global lightning frequency by about 1.6%

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Analyzing Oxygen Atom Distribution in FDA‐Approved Drugs to Enhance Drug Discovery Strategies

Chemical Biology and Drug Design

This work presents a comprehensive analysis of oxygen atoms in approved drugs, aiming to streamline drug design and discovery efforts. In approved drugs, majority of oxygen atoms are present within 4 from the COM of the molecule.