PLOS: DNA Science

MAY 25, 2023

In these 50 or so conditions, symptoms may appear earlier and worsen from generation to generation, as the mutant gene grows, adding copies of a 3- or 4-base DNA sequence. The duo is designed to correct the mutation, the MAb targeting the siRNA to the gene behind MD1, where it snips out DNA repeats.

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Treatment DNA RNA Clinical Trials 52

PLOS: DNA Science

JUNE 22, 2023

A “DNA damage checkpoint” rests the cell cycle while special proteins repair damaged DNA. Here’s an article from 2002. The post How Targeted Cancer Drugs Disrupt the Cell Cycle appeared first on DNA Science. An “apoptosis checkpoint” turns on as mitosis begins.

Drugs 52

Drugs Small Molecule DNA Bioethics 52

The Pharma Data

FEBRUARY 22, 2022

After ten years at Sony France as Chief Financial Officer (2000-2002), and then General Secretary, she was appointed Chief Financial Officer of Europacorp Group in 2011. She began her career in 1992 at PricewaterhouseCoopers where she worked as an auditor and then a financial advisor.

Clinical Trials 52

Clinical Trials DNA Science Clinical Development 52

BMG Labtech

MARCH 8, 2023

DNA, proteins, polysaccharides, etc.). They are strongly oxidizing and, at high concentrations, are deleterious to cells damaging DNA, proteins and lipids, and eventually leading to cell death. Alberts B, 2002, Energy Conversion: Mitochondria and Chloroplasts, Molecular Biology of the Cell (4th ed.). 7 (3): 276–82. PMC 1456893.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. Experiments around using genetically modified organisms to produce proteins have been taking place since the earliest days of the recombinant DNA revolution.

Vaccine 87

Vaccine Engineering Production RNA 87

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

DNA 113

DNA Laboratories Hospitals Virus 113

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

DNA 52

DNA Engineering Therapies RNA 52

PLOS: DNA Science

JULY 11, 2024

In the classic film Jurassic Park (JP) from 1993, disasters unfurl at a theme park populated with dinosaurs cloned from reptile DNA in mosquitoes fossilized in amber, with modern frog DNA filling in gaps. The animals were cloned from DNA in bits of preserved ear bones, and doctored a bit. percent of our DNA sequence with chimps?

DNA 52

DNA Science Doctors Engineering 52

Drug Target Review

DECEMBER 13, 2024

Innovations in payload substances, such as topoisomerase inhibitors (topo-1i), and next-generation DNA- damaging agents to replace older, more toxic agents. Landscape of clinical drug development of ADCs used for the pharmacotherapy of cancers: an overview of clinical trial registry data from 2002 to 2022. BMC Cancer. 2024;24(1):898.

Therapies 98

Therapies Treatment Clinical Trials Drugs 98

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Across the tree of life, organisms strictly require exactly one of the two chiral forms of their molecular building blocks — amino acids, nucleotides of RNA and DNA. 4 As far as we know, right-handed proteins never occur naturally.

RNA 105

RNA DNA Vaccine Virus 105

NIH Director's Blog: Drug Development

MAY 15, 2018

It relies on transposons—snippets of DNA sometimes referred to as “jumping genes” for inserting themselves randomly into the genome—to disrupt thousands of genes in the P. 2002 Oct 3;419(6906):498-511. [3] falciparum genome. 3] Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis.

Drug Development 52

Drug Development Drugs Disease Treatment 52

Agency IQ

MARCH 29, 2024

The Rubber Tire Manufacturing NESHAP, subpart XXXX, was promulgated pursuant to section 112(d) of the Clean Air Act (CAA) on July 9, 2002, with corrections promulgated on March 12, 2003. EPA, 955 F.3d 3d 1088 (D.C. 2020) (“LEAN”).

Regulations 40

Regulations Compliance Production Government 40

Codon

AUGUST 10, 2023

Cell (2002). Nature Genetics (2002). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Scitable, by Nature Education.

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Cell (2002). Nature Genetics (2002). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. . & Reinberg D. & Shamir R.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

PLOS: DNA Science

MAY 29, 2025

In MiddleSex She Becomes He The classic tale based on a single-gene condition is Middlesex, by Jeffrey Eugenides, a Pulitzer Prize winner published in 2002. I reviewed the book here at DNA Science. The Sirens Mimic Mermaids Middlesex is from 2002, The Covenant of Water from 2023, The Sirens , 2025.

Disease 76

Disease DNA Science Government 76

Broad Institute

JANUARY 7, 2025

These stories and diagnoses, made possible by clinical genomics labs around the world analyzing DNA from patients and sharing their findings with each other to improve medical care, werent always so common. In 2002, when Rehm was building such a lab at Mass General Brigham, she quickly realized how siloed these labs were.

Disease 121

Disease Science Laboratories Medical Schools 121

Codon

DECEMBER 1, 2024

Many students are taught that the Central Dogma is simply “DNA → RNA → protein.” In 1956, Crick was working on a lecture that would bring together what was then known about the “flow of information” between DNA, RNA, and protein in cells.

RNA 135

RNA DNA Molecular Biology Virus 135

PLOS: DNA Science

MAY 1, 2025

Jeffrey Eugenides’ 2002 compelling novel Middlesex traces a family with the condition stemming from siblings forced to have sex while in hiding during the Armenian genocide during World War I. DNA Science covered the genetics of transgender identity in 2018 , with an update in 2020. It’s one of my favorites.

Government 94

Government DNA Science International 94

Codon

NOVEMBER 24, 2024

For example, “between 1878 and 1953, numerous attempts were made to fertilize mammalian eggs in vitro,” according to a 2002 review on the history of IVF. Some of the early scientific successes made by Rock and others may have also been illusory. More commonly, though, new technologies fix problems created by older ones.

Regulations 63

Regulations DNA Hospitals Trials 63