article thumbnail

2025 Merkin Prize in Biomedical Technology awarded to pioneers of CAR T-cell therapy

Broad Institute

In 2007, Sadelain and Rivire treated their first patient with leukemia, and in 2009, published details on how they manufactured personalized CAR T cells to treat patients with aggressive leukemia. We treated our first patient with CD19 CAR T cells back in 2007. That boosting signal is a staple of all CARs used today.

Therapies 119
article thumbnail

Inavolisib

New Drug Approvals

1, 2007, 41-44) (2.30 Step 11: (S)-4-Difluoromethyloxazolidin-2-one (MOL) (CDX) HCl in dioxane (4 N, 5.0 mL, 20 mmol) was added to a solution of (R)-1-(tert-butyldimethylsilanyloxymethyl)-2,2-difluoroethylamine ( Org. mmol) in methanol (5.0 mL) and the reaction mixture was stirred at room temperature for 2 hours.

FDA 57
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

BioSensics Joins KIF1A.ORG’s Mission to Support KAND Natural History Study

KIF1A

Founded in 2007 by three scientists from Harvard, BioSensics has created new paradigms in using wearable sensors in healthcare and revolutionized the medical alert industry by creating technologies that are now being used by thousands of older adults.

article thumbnail

Gepirone

New Drug Approvals

5] It was submitted for the preregistration (NDA) phase again in May 2007 after adding additional information from clinical trials as the FDA required in 2009. 1] It is taken orally. [1] 1] Side effects of gepirone include dizziness , nausea , insomnia , abdominal pain , and dyspepsia (indigestion). [1] 5] SYN Synthesis Ormaza, V.

FDA 62
article thumbnail

Automated red blood cell exchange: bridging treatment gaps in sickle cell disease care

Drug Target Review

Since 2007 he has held senior positions in the medical device industry, managing a wide range of business units including: US sales and marketing, research and development, quality& regulatory, scientific, and medical affairs and market access.

Disease 52
article thumbnail

Syringe services for people who inject drugs are enormously effective, but remain underused

National Institute on Drug Abuse: Nora's Blog

2007 Jul 10;89(2-3):214-22. Epub 2007 Feb 5. Higher syringe coverage is associated with lower odds of HIV risk and does not increase unsafe syringe disposal among syringe exchange program clients. Drug Alcohol Depend. doi: 10.1016/j.drugalcdep.2006.12.035. 2006.12.035. PMID: 17280802; PMCID: PMC2562866.

Drugs 119
article thumbnail

Landiolol

New Drug Approvals

The resulting Landiolol hydrochloride 2 has very high enantiomeric purity.

FDA 62