2017 - Drug Discovery Digest

Law enforcement seizures of psilocybin mushrooms rose dramatically between 2017-2022

SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

Law enforcement seizures of “magic mushrooms” or “shrooms” containing the psychoactive component psilocybin increased dramatically in the United States between January 2017 and December 2022, according to a new study funded by the National Institute on Drug Abuse, part of the National Institutes of Health.

Drugs

Total Solar Eclipse in 2017 Linked to Brief Rise in Traffic Accidents

Drugs.com

MARCH 25, 2024

traffic accidents around the time of a solar eclipse back in 2017.The MONDAY, March 25, 2024 -- Ahead of a total solar eclipse arriving April 8, new research finds there was a temporary rise in U.S. The area in the United States covered by the total.

Research

Antipsychotic Use Declined in Young Children From 2009 to 2017

The Pharma Data

NOVEMBER 13, 2020

Antipsychotic Use Declined in Young Children From 2009 to 2017. 13, 2020 — Among privately insured young children, antipsychotic use declined from 2009 to 2017, according to a study published online Oct. percent by 2017 (linear trend: ?0.017 Professional. FRIDAY, Nov. Bushnell, Ph.D., young children (ages 2 to 7 years).

Research

Sledding-Related Injuries Decreased From 2008 to 2017

The Pharma Data

DECEMBER 23, 2020

Sledding-Related Injuries Decreased From 2008 to 2017. Professional. WEDNESDAY, Dec. 23, 2020 — The number of sledding-related injuries has decreased in recent years, but the rate of injuries is still concerning, according to a study published online Dec. 14 in the Clinical Journal of Sports Medicine. Evans, Ph.D., Evans, Ph.D.,

Hospitals

Hospitals Research

61.6 Cases of Diabetic Ketoacidosis Per 10,000 Admissions Reported in 2017

The Pharma Data

OCTOBER 28, 2020

cases per 10,000 admissions in 2017 and is higher in men than women, according to a research letter published online Oct. In 2017, the total charges among DKA patients were $6,757,748,178 (mean, $30,836.19). WEDNESDAY, Oct. 28, 2020 — The incidence of diabetic ketoacidosis (DKA) was 61.6 13 in Diabetes Care. More than half (53.3

Research

New Combo Drug Therapy Halves Death Risk From Advanced Hodgkin Lymphoma

Drugs.com

OCTOBER 16, 2024

She's also a survivor of advanced Hodgkin lymphoma, who first got diagnosed at the age of 25 back in 2017.After WEDNESDAY, Oct. 16, 2024 -- Jenna Cottrell is a young sports reporter working for a TV station in the Rochester, N.Y., After 12 rounds.

Therapies

Therapies Drugs

Large Language Models and Biological Foundation Models

Broad Institute

OCTOBER 11, 2024

Large Language Models and Biological Foundation Models By lcopelan@broadinstitute.org October 11, 2024 Large Language Models and Biological Foundation Models Syed Rizvi Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

Behind the new kind of cell therapy that just won FDA approval

BioPharma Drive: Drug Pricing

FEBRUARY 21, 2024

One expert views Amtagvi’s approval as a catalyst for further investment in TIL therapies, akin to how Kymriah’s 2017 clearance buoyed CAR-T treatment.

FDA Approval

FDA Approval Therapies FDA Treatment

Community Day

Broad Institute

SEPTEMBER 30, 2024

Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

Water Beads Can Expand Inside Body, Causing Kids Serious Harm. Should They Be Banned?

Drugs.com

SEPTEMBER 25, 2023

25, 2023 -- Ashley Haugen’s 13-month-old daughter, Kipley, woke up projectile vomiting in their Texas home one morning in July 2017. MONDAY, Sept. The Haugens took her to the doctor after it became apparent she wasn’t keeping anything down.

Doctors

J&J sends blood pressure drug back to Idorsia

BioPharma Drive: Drug Pricing

SEPTEMBER 6, 2023

The decision is the latest in a series of setbacks for the Actelion spinout and ends a lucrative partnership that began in 2017.

Drugs

Lightning Talks

Broad Institute

AUGUST 30, 2024

Lightning Talks By lcopelan@broadinstitute.org August 30, 2024 Lightning Talks MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 (..)

TBD

Broad Institute

AUGUST 28, 2024

TBD By lcopelan@broadinstitute.org August 28, 2024 TBD Brian Cleary MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

TBD

Broad Institute

AUGUST 22, 2024

TBD By lcopelan@broadinstitute.org August 22, 2024 TBD Abraham Gihawi MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Modeling genotype to phenotype: a search for the right variables and the “natural” objects of selection

Broad Institute

OCTOBER 8, 2024

Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 Fall 2015 Summer 2015 Spring 2015 Spring 2014 Fall 2014

Microbiome

Broad Institute

AUGUST 8, 2024

Microbiome By lcopelan@broadinstitute.org August 8, 2024 Microbiome Victoria Pascal MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring (..)

Molecular dynamics

Broad Institute

AUGUST 8, 2024

Molecular dynamics By lcopelan@broadinstitute.org August 8, 2024 Molecular dynamics Ashkan Fakharzadeh Ghaan MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring (..)

TBD

Broad Institute

AUGUST 31, 2023

TBD By lcopelan@broadinstitute.org August 31, 2023 Yuhan Hao Neptune Bio Related Resources [link] MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Sharing quality information on all things related to hearing: Wiki4WorldHearingDay2023

NIOSH Science Blog: Drugs

JUNE 7, 2023

2017; WHO, 2017). No matter the country, people with hearing difficulties often take years to seek care. Even when they do, uptake of recommended interventions, particularly hearing aids, is low (Wilson et al., To “raise awareness on how to

International

Tensor factorization + single-cell rna-seq

Broad Institute

AUGUST 8, 2024

Tensor factorization + single-cell rna-seq By lcopelan@broadinstitute.org August 8, 2024 Tensor factorization + single-cell rna-seq Neriman Tokcan UMass Boston MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall (..)

RNA

Single-cell genomics + LLM or OT

Broad Institute

AUGUST 8, 2024

Single-cell genomics + LLM or OT By lcopelan@broadinstitute.org August 8, 2024 Single-cell genomics + LLM or OT David van Dijk Yale University MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 (..)

VALILTRAMIPROSATE

New Drug Approvals

OCTOBER 12, 2024

ALZ-801 is converted to homotaurine in vivo, but is more easily absorbed and lasts longer in the blood than tramiprosate. Tramiprosate was reported to inhibit Aβ42 aggregation into toxic oligomers ( Gervais et al., 2007 ; Kocis et al., 2016 ; Abushakra et al., Alzheon licensed ALZ-801 from NeuroChem and is developing it for Alzheimer’s disease.

Pharmacokinetics

Pharmacokinetics Small Molecule Disease Licensing

Medical Costs for Kids' Mental Health Jumped 31% in 5 Years

Drugs.com

MARCH 11, 2024

MONDAY, March 11, 2024 -- The cost to American families of caring for a child with a mental health condition rose by almost a third between 2017 and 2021, a new report finds, to an average $4,361 per year. Overall, American families spent an.

Police Seizures of Pills With Fentanyl Have Skyrocketed

Drugs.com

MAY 13, 2024

MONDAY, May 13, 2024 -- Police seizures of illicit fentanyl pills have soared in recent years, a new study has found.The number of pills containing fentanyl seized by law enforcement was 2,300 times greater in 2023 than in 2017 – more than 115.

Adrenocortical carcinoma: No mitotane for low risk of recurrence

SCIENMAG: Medicine & Health

AUGUST 26, 2023

In 2017, the teams of Massimo Terzolo and Martin Fassnacht published a study in the New England Journal of Medicine that provided evidence for the efficacy of Mitotane in the prevention of recurrence in adrenocortical carcinoma.

Therapies

Therapies Drugs

Sediment movement during Hurricane Harvey could negatively impact future flooding, prove costly to Houston, UH study finds

SCIENMAG: Medicine & Health

AUGUST 26, 2023

Enormous amounts of sediment, or sand and mud, flowed through Houston waterways during Hurricane Harvey in 2017, due in part to modifications made by humans to bayous, rivers and streams over the past century, that could seriously impact future flooding events and be costly to the City of Houston.

Science

Jennifer Listgarten

Broad Institute

APRIL 22, 2024

From 2007 to 2017 she was at Microsoft Research, through Cambridge, MA (2014-2017), Los Angeles (2008-2014), and Redmond, WA (2007-2008). She is also a member of the steering committee for the Berkeley AI Research (BAIR) Lab. She completed her Ph.D.

Molecular Biology

Molecular Biology Engineering Science Research

Driving efficiency across upstream bioprocess workflow

Drug Target Review

MARCH 15, 2024

2017 Nov;33(6):1468-1475. Epub 2017 Sep 7. Cell Gene Therapy Insights 2017; 3(2), 131-158, 10.18609/cgti.2017.014. Leveraging a CHO cell line toolkit to accelerate biotherapeutics into the clinic. Biotechnol Prog. doi: 10.1002/btpr.2548. PMID: 28842948. Narayanavari SA, Izsvák Z. Patel T, Ingham C, Fleming J, et al.

Engineering

Engineering Molecular Biology Protein Expression Medical Schools

Robots cause company profits to fall – at least at first

SCIENMAG: Medicine & Health

AUGUST 2, 2023

The researchers, from the University of Cambridge, studied industry data from the UK and 24 other European countries between 1995 and 2017, and found that at low levels of adoption, robots have […]

Research

Hexagonal MBene: A promising platform for the electrocatalytic nitrogen reduction reaction

SCIENMAG: Medicine & Health

JULY 7, 2023

“In 2017, we reported a new family of 2D transition metal borides as analogues to MXenes and coined a catchy name for them, MBenes,” said paper author Zhimei […] They published their work on July. 6 in Energy Material Advances. Credit: Ya Gao, Beihang University They published their work on July.

Engineering

Michelson Prizes, Next-Generation Grants ePanel Features Rising Stars in Immunology & Vaccine Innovation

keypoint

APRIL 16, 2024

The prize has been awarded annually since 2017, as a collaboration between the Michelson Medical Research Foundation and the Human Immunome Project.

Vaccine

Vaccine International Research

FDA finalizes guidance extending inspection authority to medical devices

Agency IQ

JUNE 21, 2024

While this policy has been in place since 2012 for drug facilities, the same authority was only extended to FDA’s oversight of medical devices in 2017. The FDA has now finalized a revision to its guidance on the subject to provide more examples and incorporate device considerations. Fill out the form to read the full article.

FDA

FDA Production Drugs

Deaths from Excessive Alcohol Use in the US, 2016-2021

Common Sense for Drug Policy Blog

MARCH 4, 2024

Deaths from Excessive Alcohol Use in the US, 2016-2021 "From 2016–2017 to 2020–2021, the average annual number of U.S. deaths from excessive alcohol use increased by more than 40,000 (29%), from approximately 138,000 per year (2016–2017) to 178,000 per year (2020–2021).

Alpha Missense

Broad Institute

MARCH 7, 2024

Alpha Missense By lcopelan@broadinstitute.org March 7, 2024 Jun Cheng MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring (..)

AgencyIQ Guidance Tracker: European medical device and diagnostics guidance documents

Agency IQ

MARCH 25, 2024

Europe enacted the medical device (MDR) and IVD regulations (IVDR) in May 2017 but gave manufacturers and other stakeholders, including the regulators themselves, time for implementation. Our new resource aims to help make this a little bit easier. Fill out the form to read the full article.

Regulations

Postdoc flash talks

Broad Institute

FEBRUARY 15, 2024

Postdoc flash talks By lcopelan@broadinstitute.org February 15, 2024 MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring (..)

TBD

Broad Institute

FEBRUARY 12, 2024

TBD By lcopelan@broadinstitute.org February 12, 2024 Julia Salzman MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

TBD

Broad Institute

FEBRUARY 12, 2024

TBD By lcopelan@broadinstitute.org February 12, 2024 Tavor Baharav MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

Alpha Missense

Broad Institute

JANUARY 29, 2024

Alpha Missense By lcopelan@broadinstitute.org January 29, 2024 Žiga Avsec Google DeepMind MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 (..)

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Jose Alquicira-Hernandez MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 (..)

Protein Structure Prediction (TBD)

Broad Institute

JANUARY 29, 2024

Protein Structure Prediction (TBD) By lcopelan@broadinstitute.org January 29, 2024 Sergey Ovchinnikov MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

TBD

Broad Institute

JANUARY 29, 2024

TBD By lcopelan@broadinstitute.org January 29, 2024 Joshua Meier MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 Spring 2017 Fall 2016 Spring 2016 (..)

When Worlds Collide: The Theory of Real-World Evidence Meets Reality

FDA Law Blog: Biosimilars

MAY 13, 2024

It was Congress that intervened in 2022, to mandate FDA to issue or revise its 2017 guidance on considerations for the use of RWD and RWE to support regulatory decision-making for devices to clarify its regulatory expectations. This guidance, when finalized, will replace the original version of this document finalized in 2017.

FDA

FDA Production Trials Pharmacy

Valid hypothesis testing after clustering

Broad Institute

JANUARY 29, 2024

Valid hypothesis testing after clustering By lcopelan@broadinstitute.org January 29, 2024 Yiqun Chen MIA About Current Schedule Video Playlist Resources All talks Contact us MIA Talks Search - Any - Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

Law enforcement seizures of psilocybin mushrooms rose dramatically between 2017-2022

Total Solar Eclipse in 2017 Linked to Brief Rise in Traffic Accidents

Trending Sources

Antipsychotic Use Declined in Young Children From 2009 to 2017

Sledding-Related Injuries Decreased From 2008 to 2017

61.6 Cases of Diabetic Ketoacidosis Per 10,000 Admissions Reported in 2017

New Combo Drug Therapy Halves Death Risk From Advanced Hodgkin Lymphoma

Large Language Models and Biological Foundation Models

Behind the new kind of cell therapy that just won FDA approval

Community Day

Water Beads Can Expand Inside Body, Causing Kids Serious Harm. Should They Be Banned?

J&J sends blood pressure drug back to Idorsia

Lightning Talks

TBD

TBD

Modeling genotype to phenotype: a search for the right variables and the “natural” objects of selection

Microbiome

Molecular dynamics

TBD

Sharing quality information on all things related to hearing: Wiki4WorldHearingDay2023

Tensor factorization + single-cell rna-seq

Single-cell genomics + LLM or OT

VALILTRAMIPROSATE

Medical Costs for Kids' Mental Health Jumped 31% in 5 Years

Police Seizures of Pills With Fentanyl Have Skyrocketed

Adrenocortical carcinoma: No mitotane for low risk of recurrence

Sediment movement during Hurricane Harvey could negatively impact future flooding, prove costly to Houston, UH study finds

Jennifer Listgarten

Driving efficiency across upstream bioprocess workflow

Robots cause company profits to fall – at least at first

Hexagonal MBene: A promising platform for the electrocatalytic nitrogen reduction reaction

Michelson Prizes, Next-Generation Grants ePanel Features Rising Stars in Immunology & Vaccine Innovation

FDA finalizes guidance extending inspection authority to medical devices

Deaths from Excessive Alcohol Use in the US, 2016-2021

Alpha Missense

AgencyIQ Guidance Tracker: European medical device and diagnostics guidance documents

Postdoc flash talks

TBD

TBD

Alpha Missense

TBD

Protein Structure Prediction (TBD)

TBD

When Worlds Collide: The Theory of Real-World Evidence Meets Reality

Valid hypothesis testing after clustering

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