Codon

JUNE 5, 2025

In 2017, Eugene Koonin’s group at the National Center for Biotechnology Information proposed a new nomenclature for CRISPR-Cas systems. 6 Like Cas12, Cas13 initially had a different name (C2c2) but was renamed in the Koonin group’s 2017 article. 5 At the time of this initial characterization, Cas12 was known as Cpf1.

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DNA RNA Clinical Trials Engineering 81

New Drug Approvals

JUNE 11, 2025

Archived from the original on 24 September 2017. . ^ “FDA Rules Favorably On Efficacy Of Travivo (Gepirone ER) For Treatment Of Major Depressive Disorder” (Press release). 17 March 2016. Retrieved 23 January 2018. Jump up to: a b Fabre LF, Brown CS, Smith LC, Derogatis LR (May 2011). 8 (5): 1411–1419. doi : 10.1111/j.1743-6109.2011.02216.x.

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New Drug Approvals

JULY 10, 2025

2017 Oct;38(9):1355-1361. [Content Brief] [2]. Petremann M, et al. Oral Administration of Clinical Stage Drug Candidate SENS-401 Effectively Reduces Cisplatin-induced Hearing Loss in Rats. Otol Neurotol. Content Brief] //////////ARAZASETRON BESYLATE, R-Azasetron besylate, UXP39EQ477, SENS-401, SENS 401

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Drugs 62

The Premier Consulting Blog

JANUARY 14, 2025

Established in 2017 under the 21st Century Cures Act, the OCE brings together multidisciplinary scientific expertise to accelerate the review and approval of drugs, biologics, and medical devices for cancer care.

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Clinical Trials Therapies FDA Trials 52

Drug Patent Watch

JANUARY 9, 2025

In 2017, small and medium-sized biotech companies accounted for 51% of FDA market approvals, while large pharma companies were the originators in only 28% of approvals[4]. Understanding the CDMO Landscape Before we delve into the nitty-gritty of best practices, it’s essential to grasp the current state of the CDMO industry.

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Compliance Drug Development Pharma Companies Therapies 52

New Drug Approvals

MAY 8, 2025

Compounds useful as kinase inhibitors (WO 2017/103611 A1). 1] [2] [4] It inhibits B cell lymphocyte proliferation and survival by binding and inhibiting Bruton’s tyrosine kinase (BTK). [5] 5] It is taken by mouth. [1] 2] PATENTS Guisot, N. World Intellectual Property Organization. mmol) and 1,1,1- trifluoroacetone (74.9

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FDA Approval FDA Therapies Trials 52

New Drug Approvals

MAY 15, 2025

2017, 8, 9, 975980 [link] The predominant expression of phosphoinositide 3-kinase (PI3K) in leukocytes and its critical role in B and T cell functions led to the hypothesis that selective inhibitors of this isoform would have potential as therapeutics for the treatment of allergic and inflammatory disease. . 10 mbar vacuum.

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FDA Approval FDA Treatment International 62

Drug Target Review

NOVEMBER 7, 2024

Yet, there is a promising future for agonist antibodies of immune checkpoint regulators as researchers continue to unveil their intricate mechanisms of action, offering novel avenues for advancing precision medicine in immunology and inflammatory disorders. References 1 Tinoco R, Otero DC, Takahashi AA, Bradley LM.

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Disease Immune Response Regulations Engineering 52

New Drug Approvals

JULY 8, 2025

US FDA granted fast track designation for pritelivir in 2017 and breakthrough therapy designation 2020. It is currently in Phase III clinical development by the German biopharmaceutical company AiCuris Anti-infective Cures AG. PAPER By: Carta, Fabrizio ; et al.

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Virus DNA Clinical Trials Treatment 62

New Drug Approvals

APRIL 19, 2025

Dean L (2017). July 2017). PMID 26261777. “Metoprolol Therapy and CYP2D6 Genotype” In Pratt VM, McLeod HL, Rubinstein WS, et al. Medical Genetics Summaries. National Center for Biotechnology Information (NCBI). PMID 28520381. Bookshelf ID: NBK425389. Ojima T, Nakamori M, Nakamura M, Katsuda M, Hayata K, Kato T, et al.

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FDA Clinical Trials Treatment Trials 62

FDA Law Blog: Biosimilars

JANUARY 9, 2025

As part of the Food and Drug Administration Safety and Innovation Act (known as FDASIA) and later under the FDA Reauthorization Act of 2017 (known as FDARA), a drug or medical device can be deemed adulterated if a regulated company delays, denies, or limits an inspection, or refuses to permit an entry or inspection.

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FDA Regulations International Drugs 106

New Drug Approvals

JULY 10, 2025

PAPER ACS Medicinal Chemistry Letters (2011), 2(2), 91-96 [link] PAPER Science (Washington, DC, United States) (2017), 356(6342), 1084-1087 Pfizer Products Inc.WO2008047229 References ^ Johnson DS, Stiff C, Lazerwith SE, Kesten SR, Fay LK, Morris M, et al. 2017 Jan 1:1091581817725272. g (95%) of product. February 2011). 2 (2): 91–96.

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Production Treatment Clinical Trials International 62

Perficient: Drug Development

MARCH 4, 2025

Women in Digital Breakfast This highly popular breakfast event has been a Perficient tradition since 2017 and this year were excited to partner with Adobe to share it with Summit attendees again. While were there, attendees will have several opportunities to engage with us. Read on to learn more about where to find us!

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Marketing Government 52

Broad Institute

JUNE 4, 2025

Talk title coming soon By Nadya Karpova June 4, 2025 Talk title coming soon Lorin Crawford Microsoft Research New England (MSR) Add to calendar Talks Search - Any - Fall 2025 Spring 2025 Fall 2024 Spring 2024 Fall 2023 Spring 2023 Fall 2022 Spring 2022 Fall 2021 Spring 2021 Fall 2020 Spring 2020 Fall 2019 Spring 2019 Fall 2018 Spring 2018 Fall 2017 (..)

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Research 40

BioPharma Drive: Drug Pricing

JUNE 27, 2025

Dive Insight: Since the FDA’s approval of Novartis’ Kymriah for leukemia in 2017, six more CAR-T therapies have reached market. These medicines are made from a patient’s own immune cells, extracted from the body and engineered in a lab to hunt down specific proteins found on the surface of malignant clones.

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Therapies FDA Treatment Licensing 178

The Pharma Data

JUNE 19, 2025

Since the inception of the G20 Health Ministers’ Meeting in 2017, the H20 Summit has grown into a central convening space that links public health advocacy with high-level policy and investment strategy.

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Government International Disease Vaccine 40

FDA Law Blog: Biosimilars

APRIL 8, 2025

The DCAP was an initiative launched in 2017 to remove barriers to generic drug development, approval, and market entry (see our previous post here ). About one third of these PSGs are for complex products and many reflect what OGD and DPD learned about the science of equivalence from GDUFA-funded regulatory science research.

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FDA Drugs Production Drug Development 144

Codon

JULY 14, 2025

A study using 2017 interview data suggested that 23.4 Further studies looked at whether aspirin was effective at preventing cardiovascular disease (including heart attacks and strokes), and led to recommendations promoting low-dose aspirin use. percent of adults 40 years or older in the U.S.

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Treatment Laboratories Disease Drugs 85

FDA Law Blog: Biosimilars

APRIL 14, 2025

Baumhardt, Principal Medical Device Regulatory Expert In January 2025, FDA posted the 2024 Annual Report concerning the Accreditation Scheme for Conformity Assessment (ASCA) program as required by Medical Device User Fee Amendments of 2017 (MDUFA IV).

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Laboratories FDA International 59

Drug Channels

JUNE 20, 2025

Since 2017, 24 states have passed 38 laws targeting healthcare transparency , with a strong focus on unraveling the complex economics of pharmacy benefit managers (PBMs). Last week, President Trump signed yet another executive order , this time promising to make healthcare pricing more transparent.

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Pharmacy Government Research Drugs 80

Drug Channels

MARCH 5, 2025

Since 2017, 24 states have passed 38 laws targeting healthcare transparency , with a strong focus on unraveling the complex economics of pharmacy benefit managers (PBMs). Last week, President Trump signed yet another executive order , this time promising to make healthcare pricing more transparent.

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Pharmacy Government Drugs 40

New Drug Approvals

JULY 28, 2025

Lancet 2017, 389, 2239−2251. PPAR Research 2017 2017, 2017, 1−16. Type 2 diabetes. 128) Pan, D.-S.; Huang, L.; Chiglitazar preferentially regulates gene expression via configuration-restricted binding and phosphorylation inhibition of PPARγ. 129) Deeks, E.

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Trials Regulations Clinical Trials Production 52

Drugs.com

MARCH 25, 2024

traffic accidents around the time of a solar eclipse back in 2017.The MONDAY, March 25, 2024 -- Ahead of a total solar eclipse arriving April 8, new research finds there was a temporary rise in U.S. The area in the United States covered by the total.

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Research 224

Drugs.com

MARCH 11, 2025

adults from 2017 to 2023, according to research published in the March 6 issue of the U.S. TUESDAY, March 11, 2025 -- Decreases in exclusive cigarette smoking and increases in exclusive electronic cigarette use were seen among U.S. Centers for.

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Research 130

Perficient: Drug Development

APRIL 2, 2025

Deena was awarded the Florida Diversity Council Glass Ceiling Award in 2016, was selected as a CRN Women of the Channel Honoree in 2017, and was named to Diversity Firsts Top 50 Women in Tech 2021 and Top 100 CMOs in 2022.

Marketing 52

Marketing International Production Research 52

New Drug Approvals

JULY 21, 2025

2017, 121, 414−422. (49) Safety, pharmacokinetics and pharmacodynamics of hetrombopag olamine, a novel TPO-R agonist, in healthy individuals. Basic Clin. 49) Mei, H.; Xiong, J.;

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Small Molecule International Production Treatment 62

New Drug Approvals

JULY 18, 2025

July 2017). 98 : 379–386. doi : 10.1016/j.jpba.2014.06.019. 2014.06.019. PMID 24999865. Liu Y, Liu B, Zhang Y, Peng Y, Huang C, Wang N, et al. 105 : 150–158. doi : 10.1016/j.ejps.2017.05.009. 2017.05.009.

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RNA Clinical Trials Trials Virus 62

BioPharma Drive: Drug Pricing

SEPTEMBER 6, 2023

The decision is the latest in a series of setbacks for the Actelion spinout and ends a lucrative partnership that began in 2017.

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Drugs 286

SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

Law enforcement seizures of “magic mushrooms” or “shrooms” containing the psychoactive component psilocybin increased dramatically in the United States between January 2017 and December 2022, according to a new study funded by the National Institute on Drug Abuse, part of the National Institutes of Health.

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Drugs 93

Drugs.com

SEPTEMBER 25, 2023

25, 2023 -- Ashley Haugen’s 13-month-old daughter, Kipley, woke up projectile vomiting in their Texas home one morning in July 2017. MONDAY, Sept. The Haugens took her to the doctor after it became apparent she wasn’t keeping anything down.

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Doctors 278

BioPharma Drive: Drug Pricing

FEBRUARY 21, 2024

One expert views Amtagvi’s approval as a catalyst for further investment in TIL therapies, akin to how Kymriah’s 2017 clearance buoyed CAR-T treatment.

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Drugs.com

JANUARY 22, 2025

22, 2025 -- A sudden need to urinate is more common than previously known, but treatment is less common.Diagnoses for overactive bladder more than tripled between 2013 and 2017, after the American Urological Association (AUA). WEDNESDAY, Jan.

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Treatment 220

The Pharma Data

JULY 2, 2025

LupinLife was originally launched in 2017 as Lupin’s dedicated consumer healthcare arm. This move is designed to sharpen the company’s focus on the growing self-care segment in India, signaling Lupin’s long-term commitment to expanding its presence in the country’s burgeoning over-the-counter (OTC) health and wellness market.

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Pharmaceuticals Production Marketing Therapies 52

BioPharma Drive: Drug Pricing

FEBRUARY 26, 2025

investments, company chief David Ricks called for an extension of 2017 tax cuts and changes to Medicare's drug negotiation program. While announcing billions of dollars in new U.S.

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Drugs 177

Drugs.com

MARCH 11, 2024

MONDAY, March 11, 2024 -- The cost to American families of caring for a child with a mental health condition rose by almost a third between 2017 and 2021, a new report finds, to an average $4,361 per year. Overall, American families spent an.

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Science Daily: Pharmacology News

APRIL 3, 2025

A solar wind event from 2017 that hit Jupiter and compressed its magnetosphere created a hot region spanning half Jupiter's circumference.

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Drugs.com

APRIL 26, 2025

SATURDAY, April 26, 2025 From beetles to moths, leafhoppers and butterflies, the world's insects are vanishing at a breakneck pace.Since 2017, when European researchers reported that insect populations had declined 75% in fewer than 30 years, s.

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Research 150