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Time for change: non-human primates in drug research

Drug Target Review

Persistent challenges with NHP use Despite their biological relevance, using live NHPs in research poses several major challenges: Ethical concerns NHPs, due to their advanced cognition and social behaviour, are at the centre of ongoing ethical debates. Supply chain disruptions Availability is a critical bottleneck in NHP-based research.

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2025 Merkin Prize in Biomedical Technology awarded to pioneers of CAR T-cell therapy

Broad Institute

The Merkin Prize recognizes novel technologies that have improved human health and is administered by the Broad Institute, one of the worlds leading biomedical research institutes. The next step was to adapt cell culture techniques to enable the production of effective CAR T cells for infusion to patients.

Therapies 119
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Vamorolone

New Drug Approvals

76)Boger, D.L.Thedifferenceasingleatomcanmake:synthesisand design at the chemistry−biology interface. 2017, 82, 11961−11980. (77) 2017, 82,11961−11980. Archived from the original on 7 October 2017. Retrieved 2 July 2017. Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy.

FDA 62
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New molecular insights on medical cannabis

Drug Target Review

2 Implication of ATX in a large range of human diseases have been highlighted by both fundamental research and clinical trials. 1-5 Implication of ATX in a large range of human diseases have been highlighted by both fundamental research and clinical trials. He is a researcher at University of Oldenburg, Germany. 2017;2017:1–15.

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CAR-NK cells: promising for cancer therapy

Drug Target Review

By themselves, the NK cells showed limited efficacy, but anti-tumour efficacy was observed with co-treatment regimens (eg, monoclonal antibodies, haematopoietic stem cell transplants, whole body irradiation) and multiple dosing (tolerated well by patients).

Therapies 118
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Cancer immunotherapy: GDF-15’s role in Anti-PD-1 resistance

Drug Target Review

Prior to joining CatalYm, Christine co-founded Rigontec in 2014 where she led the company’s discovery and non-clinical development activities as Senior Vice President, Research. in North America) in late 2017. Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration.

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Precision Medicine in the Genomic Era

DrugBank

As researchers increased their ability to gather large amounts of genetic data, they gained the ability to study the genome as a whole, giving rise to the field of genomics. However, it does highlight the challenge in sufficiently defining a “condition,” both for research and clinical practice. 50 , 1700391 (2017).

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