Drug Target Review

JULY 7, 2025

Since then, pharma and biotech firms have increased investment in alternatives, including computational models, organ-on-chip systems and stem cell technologies. Experimental Biology and Medicine. Lee TYT, Coles JG, Maynes JT. iPSC-cardiomyocytes in the preclinical prediction of candidate pharmaceutical toxicity. Front Pharmacol.

Drug Research 52

Drug Research Research Animal Testing Drugs 52

Broad Institute

MAY 21, 2025

Merkin Prize in Biomedical Technology for developing chimeric antigen receptor (CAR) T-cell therapy, a groundbreaking form of personalized cancer immunotherapy that turns T cells into tumor killers and has led to durable remissions in tens of thousands of patients with previously incurable blood cancers.

Therapies 119

Therapies FDA Approval Engineering Immune Response 119

New Drug Approvals

JULY 25, 2025

Corticosteroid therapy is the current standard of care for DMD despite relatively high rates of adverse effects. 75,76 This also results in decreased glucocorticoid receptor-drive transactivation, ultimately improving the safety profile of vamorolone as compared to other corticosteroid therapies. 2017, 82, 11961−11980. (77)

FDA 57

FDA FDA Approval Treatment Clinical Trials 57

Drug Target Review

NOVEMBER 17, 2023

They recognise ‘cell stress molecules’ on the surface of infected, old, injured and cancerous cells without the need for complex pre-stimulation signals of the adaptive immune system (eg, T cells). NK cells can be readily extracted from umbilical cord blood or peripheral blood of adult donors.

Therapies 118

Therapies Clinical Trials Cell Biology Trials 118

Drug Target Review

AUGUST 24, 2023

Neutralising GDF-15 with CatalYm’s anti-GDF-15 antibody visugromab was shown to reverse its inhibitory effects and to re-sensitise tumours to anti-PD-1 treatment, achieving commensurate survival benefit of anti-GDF-15-anti-PD-1 combination therapy in vivo. in North America) in late 2017. Current Opinion in Cell Biology.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

DrugBank

JUNE 27, 2023

Their use, as well as their integration into other types of data, has enabled the development of more precise therapies. 50 , 1700391 (2017). Genetics 205 , 1003–1035 (2017). 16 , 70–70 (2017). 44 , 195–211 (2017). References 1. König,  König, I. Von Mutius, E. &

Disease 99

Disease Treatment Drugs Clinical Trials 99

Drug Target Review

OCTOBER 2, 2024

Cell and gene therapies (CGTs) have made significant advancements in treating oncological diseases, with therapies like CAR-T cell treatments transforming cancer care. However, cell-based therapies are intended to leverage those healthy cells via transplant to regenerate damaged tissue.

Therapies 98

Therapies Disease RNA Engineering 98