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Aleta’s Novel T Cell Engagers

SugarCone Biotech

These agents simultaneously bind to a tumor-associated protein on cancer cells and the CD3 protein on T-cells, facilitating a targeted anti-cancer immune response. Today, however, we turn to the TCE therapeutic class. Both explanations are plausible, but the relevant clinical data are limited. Proc Natl Acad Sci U S A 115: E2068-E2076.

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Advancements in hit identification for membrane protein drug discovery

Drug Target Review

Involved in various physiological processes, such as vision, taste, smell, immune response and neurotransmission, GPCRs are activated by various molecules including hormones, neurotransmitters and environmental stimuli, which trigger a cascade of cellular events that help regulate bodily functions. References Sun D, et al. 2022.02.002.

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The Long Road to End Tuberculosis

Codon

If present before vaccination, memory immune cells primed to destroy the environmental relatives might cross-react with and neutralize the BCG strain before it has a chance to set up an immune response against itself and M. Cell (2020). tuberculosis. Credit: Stokes J.M.

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A Visual Guide to Genome Editors

Codon

The core of the CRISPR immune response is a guide RNA (gRNA) that binds to a CRISPR-associated (Cas) protein. Traditional approaches to this problem involve the use of viral vectors , which run the risk of triggering immune responses in patients. Collectively, these repeat-protospacer regions are known as CRISPR arrays.

DNA
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Second-Generation mRNA COVID-19 Vaccine Candidate, CV2CoV, Demonstrates Improved Immune Response and Protection in Preclinical Study

The Pharma Data

Better activation of innate and adaptive immune responses was achieved with CV2CoV, resulting in faster response onset, higher titers of antibodies, and stronger memory B and T cell activation as compared to the first-generation candidate, CVnCoV. “In Induction of innate immunity was investigated via specific cytokine markers.

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Predicting Adverse Reactions to Monoclonal Antibody Drugs

addgene Blog

Antibodies administered as drugs are still immunogenic, meaning that they elicit an immune response from the body. Several factors contribute to the immunogenicity of a drug including the product origin; purity, mechanism, and stability; and sequence of biologic product, mode of administration, and dose (Lu et.al.,

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Medicago Says COVID-19 Vaccine Candidate Triggers Promising Immune Response | 2020-11-10

The Pharma Data

Canadian biopharmaceutical company Medicago has announced that its investigational COVID-19 vaccine generated “significant antibody and cellular immune responses” after two doses in all subjects in an early-stage clinical trial. The interim analysis from the phase 1 trial has been published online at the preprint server, medRxiv.