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A Visual Guide to Gene Delivery

Codon

Some diseases are caused by mutations in large genes that exceed the packaging limits of existing vectors like adeno-associated virus (AAV). AAV is a small virus that lacks a lipid membrane and carries a single-stranded piece of DNA stretching 4.7 Vectors also differ in the duration of their expression.

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Levers for Biological Progress

Codon

Scientists are already building a model that can, for example, look at which RNA molecules are expressed in a cell at t=0 and predict how those molecules will change at t=1. More specifically, it reveals that the price to sequence a human genome fell from $100 million in 2001 to $700 by 2021; a stunning collapse in price.

DNA
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AZVUDINE

New Drug Approvals

SYN [link] Azvudine was approved for the treatment of adult HIV-1 infection in China in 2021, and it was approved for conditional marketing for the treatment of SARS-CoV-2 in China in 2022. It was approved in China in 2021 as a first-in-class treatment for human immunodeficiency virus (HIV). 2021, 6, 414. (9) Target Ther.

RNA
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Moderna to Build mRNA Vaccine Portfolio Following COVID-19 Success | 2021-01-11

The Pharma Data

Moderna is following up on the success of its messenger RNA-based COVID-19 vaccine with plans to develop inoculations for numerous other infectious diseases, the company said Monday. billion expected from signed advance purchase agreements for fiscal 2021, Bancel said in a Monday call with investors. 18, 2020 ). Martin Berman-Gorvine.

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Preliminary Findings from a Phase 2a Trial of Investigational COVID-19 Therapeutic Molnupiravir

The Pharma Data

The companies today reported findings on one secondary objective from the Phase 2a study, showing a reduction in time (days) to negativity of infectious virus isolation in nasopharyngeal swabs from participants with symptomatic SARS-CoV-2 infection, as determined by isolation in Vero cell line culture. About Molnupiravir.

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Biden COVID Advisor Says Poor Preparation, Changing Virus Could Slow Vaccine Effort

The Pharma Data

21, 2021 — U.S. President Joe Biden has promised to re-energize the nation’s response to COVID-19, but one of his top pandemic advisors says that effort could be hamstrung by both the virus and the failings of the previous administration. © 2021 HealthDay. . © 2021 HealthDay. Posted: January 2021.

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Eurofins GeneScan Technologies Announces AOAC PTM Accreditation for the VIRSeek SARS-CoV-2 Detection Workflow on Environmental Surfaces under the AOAC SARS-CoV-2 Emergency Response Validation Program

The Pharma Data

11, 2021 07:11 UTC. The VIR Seek SARS-CoV-2 Solution is a comprehensive workflow for the detection of SARS-CoV-2 on environmental surfaces that includes swabbing of environmental surfaces, RNA extraction, analysis by Reverse Transcription PCR (RT-PCR) and evaluation by an advanced algorithm.

RNA