New Drug Approvals

JULY 21, 2025

Drugs 2021, 81, 1581−1585. (47) 2021, 14, 37. (50) amcrasto@gmail.com …… //////////Hetrombopag Olamine, CHINA 2021, APPROVALS 2021, Hetrombopag diolamine, SHR 8735 olamine, Hetrombopag ethanolamine, SHR-8735 olamine, V45T2I862X , RAFUTROMBOPAG OLAMINE Originator Jiangsu Hengrui Medicine Co. 47) Xie, C.;

Small Molecule

DrugBaron

JULY 19, 2022

Despite the current hype around so called “advanced therapies”, which range from gene editing to cell therapies, and the inexorable advance of biologic therapeutics such as monoclonal antibodies, even in 2022 the majority of drugs in development and reaching patients are still small organic molecules.

Small Molecule

Drug Target Review

JULY 4, 2023

These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. 2 However, when dosed at the MTD, ADCs display improved efficacy over small molecules in oncology trials. 3D rendering of Antibody Drug Conjugate Molecules.

Small Molecule

Metabolite Tales Blog

JANUARY 26, 2023

Metabolism of 2022 FDA approved small molecule drugs – Part 1 Does CYP3A4 still rule? By Julia Shanu-Wilson It won’t come as much surprise to learn that of the 17 small molecules* approved by the FDA in 2022, CYP3A4 was the major player in drug metabolism. Mühlan, 2021. References Iversen et al.,

Small Molecule

Metabolite Tales Blog

APRIL 4, 2023

Metabolism of 2022 FDA approved small molecule drugs part 2 Mixing it Up By Julia Shanu-Wilson In Part 1 of this topic we looked at metabolism of the small molecule drugs approved by the FDA in 2022 that were mediated by CYP3A4. 2021 Apr;84(4):1059-1067. We hope it was a useful two-parter! J Am Acad Dermatol.

Small Molecule

The Pharma Data

JULY 29, 2021

Loxo Oncology at Lilly, a research and development group of Eli Lilly and Company (NYSE: LLY), and Kumquat Biosciences today announced an exclusive collaboration focused on the discovery, development and commercialization of potential novel small molecules that stimulate tumor-specific immune responses.

Small Molecule

The Pharma Data

JANUARY 19, 2021

20, 2021 11:00 UTC. Dr. Clark Cheng, Chief Medical Officer and Executive Director of Aptorum Group, commented, “The clearance of our CTA application for ALS-4 drug represents a significant milestone for the company and one of a number of targeted strategic goals for 2021. About ALS-4.

Small Molecule

Drug Target Review

SEPTEMBER 25, 2024

Applying our technology has enabled us to develop a new small molecule, TT125-802, and to assign a new role to the epigenetic regulator CBP/p300 as a novel master regulator of non-oncogene resistance. This orally available small molecule binds to the bromodomain of CBP/p300 in a highly specific manner. Cancers [Internet].

Small Molecule

LifeSciVC

JANUARY 16, 2024

Small molecule GLP1s? Enthusiasm for obesity is driving development in broader metabolic disease: The obesity space has seen tremendous growth since Wegovy (high-dose formulation of semaglutide, Novo’s GLP1 agonist peptide) was first approved in mid-2021 and started flying off the shelves almost overnight.

Small Molecule

The Pharma Data

NOVEMBER 30, 2020

Biohaven acquires exclusive global rights to a portfolio of novel, small-molecule CGRP antagonists. The lead candidate, HTL0022562, has advanced through preclinical development demonstrating promising and differentiated properties for further investigation in human trials.

Small Molecule

Sygnature Discovery

DECEMBER 17, 2021

2021 is nearly over – and what a year it’s been for Sygnature! Early 2021 also saw us expand our facilities at Alderley Park , creating a second fully integrated drug discovery site that includes new state-of-the-art laboratories. The 2020 Bionow Company of the Year award We’re not one for resting on our laurels, though.

Small Molecule

The Pharma Data

NOVEMBER 26, 2020

As drug molecules become more complex so do the options to deliver them. As of today, Nanoform has two non-GMP lines on the biologics side in addition to the eight CESS ® small molecule nanoparticle technology non-GMP lines. Edward Hæggström, Nanoform CEO: “Small is powerful, also in Bio! HELSINKI , Nov.

Small Molecule

The Pharma Data

APRIL 6, 2021

Bayer will present new research across its oncology portfolio at the virtual American Association for Cancer Research (AACR) Annual Meeting 2021 , taking place over two weeks on April 10-15 and May 17-21, 2021. o Abstract 1722; April 10, 8:30am EDT. About Oncology at Bayer.

Research

Drug Target Review

MARCH 28, 2024

Between 2000 and 2020, approximately 30 percent of the newly introduced small molecule drugs were derived from natural products. He was an early employee of Recursion Pharmaceuticals, where he scaled their high-content imaging platform by multiple orders of magnitude before joining Enveda in 2021.

Production

The Pharma Data

JANUARY 19, 2021

With this kind of a start, 2021 may be scorching. Its lead candidate is CLN-081, an oral small molecule designed to be a next-generation, irreversible EGFR inhibitor. The year is starting off with a number of biopharma and life sciences initial public offerings (IPOs). TCR2 Therapeutics – The Cambridge, Mass.

Small Molecule

The Pharma Data

DECEMBER 13, 2020

The full abstract will be made available online via [link] at 5:00 PM (EST) on 11 January, 2021. Session Date and Time: 1/17/2021, 2:30 PM-3:15 PM (PST). Session Date and Time: 1/17/2021, 2:30 PM-3:15 PM (PST). Due to the COVID -19 pandemic, the event will be hosted virtually. About Silmitasertib.

Small Molecule

The ChEMBL-og

DECEMBER 6, 2023

In our portfolio of chemical biology services, alongside our established database of bioactivity data for drug-like molecules ChEMBL , our dictionary of annotated small molecule entities ChEBI , and our compound cross-referencing system UniChem , we also deliver a database of annotated patents! Good question!

Small Molecule

Drug Target Review

JUNE 19, 2024

Transplanting cells could prove to be more beneficial than treating a particular condition with a small molecule or an antibody, and that really speaks to the power of cell therapy. Just like small molecules and antibodies, cell therapies are changing how we treat patients.

Therapies

The Pharma Data

JANUARY 31, 2021

1, 2021 12:16 UTC. Cannabinoids are a diverse class of small molecules that interact on the g-coupled receptor subtypes CB1 and CB2. Cannabinoids are most commonly associated with the cannabis plant, however now may be produced using traditional small molecule synthesis methods. Issuance of U.S. SILVERTHORNE, Colo.–(

Small Molecule

The Pharma Data

AUGUST 7, 2021

Vividion’s platform is able to produce a variety of small molecule therapies across indications, with initial focus on targets relevant to oncology and immunology. The acquisition of Vividion strengthens Bayer’s small molecule capabilities and expands Bayer’s reach into new modalities.

Small Molecule

The Pharma Data

JANUARY 25, 2021

26, 2021 13:00 UTC. –( BUSINESS WIRE )– Veralox Therapeutics, a biotechnology company developing first-in-class small molecule therapeutics that treat the underlying pathologies of diseases with significant unmet medical needs, today announced that the U.S. FREDERICK, Md.–( About VLX-1005.

FDA

The Pharma Data

JANUARY 19, 2021

19, 2021 (GLOBE NEWSWIRE) — Fulcrum Therapeutics, Inc. The offering is expected to close on January 22, 2021, subject to customary closing conditions. CAMBRIDGE, Mass., per share, for total gross proceeds of $44.0 million, before deducting underwriting discounts and commissions and offering expenses payable by Fulcrum.

Small Molecule

Nvidia Developer: Drug Discovery

MARCH 21, 2023

New supercomputing-scale large language models (LLMs) that understand biology and chemistry text are helping scientists understand proteins, small molecules, DNA, and biomedical text. These state-of-the-art AI models help generate de novo proteins and molecules and predict the 3D structures of proteins.

Small Molecule

The Pharma Data

OCTOBER 15, 2020

Vertex Pharmaceuticals has decided to give up on its experimental VX-814, a small molecule drug for the rare genetic disease Alpha-1 antitrypsin deficiency (AATD), canning the drug’s development after seeing lackluster results from an early phase 2 trial.

Disease

The Pharma Data

MARCH 25, 2021

The manuscript was published in the March 25, 2021 issue of NEJM. Abrocitinib is an oral small molecule that selectively inhibits Janus kinase (JAK) 1. Both doses of abrocitinib met the co-primary study endpoints. For additional information about the JADE COMPARE study, please visit [link]. About Abrocitinib.

Small Molecule

LifeSciVC

AUGUST 5, 2024

But that initial quote isn’t from 2024, it is from an interview in 2021 with Mark Levin, CEO at Millennium (MIT Technology Review). AI-based drug discovery biotechs expect that traditional drug discovery will be replaced with an AI-based paradigm that is faster, less expensive and yields a greater rate of success. One final parallel to 2001.

Molecular Biology

The Pharma Data

OCTOBER 4, 2021

The authors at GSK and CCDC completed a robust analysis of the small molecule crystal structures containing X-ray diffraction results from GSK and its heritage companies for the past 40 years. million small-molecule organic and metal-organic crystal structures from researchers all over the world. CrystEngComm, 2021.

Small Molecule

The ChEMBL-og

SEPTEMBER 30, 2024

Now it is the time to explain what they do: Patents with small molecules If you are using SureChEMBL, it's likely that you are looking for small molecules. For this reason, we introduced a new filter named "Patents with small molecules". In addition, we have introduced two new buttons under the search field.

Small Molecule

The Pharma Data

JANUARY 13, 2021

14, 2021 11:00 UTC. Knopp’s clinical-stage oral small molecule, dexpramipexole, is in Phase 2 clinical trials in moderate-to-severe eosinophilic asthma. Knopp’s preclinical Kv7 platform is directed to small-molecule treatments for developmental and epileptic encephalopathies, other epilepsies, neuropathic pain, and tinnitus.

Trials

The Pharma Data

NOVEMBER 15, 2020

In a deal set to be finalized early in 2021, Urovant Sciences has agreed to be fully acquired by largest investor and close partner, Sumitovant Biopharma. Sumitovant is a global biopharmaceutical company with a pipeline similarly focused on uterine fibroids, advanced prostate cancer and endometriosis. .

Science

The Pharma Data

JANUARY 5, 2021

06, 2021 (GLOBE NEWSWIRE) — Relay Therapeutics, Inc. Morgan Healthcare Conference on Tuesday, January 12, 2021 at 4:30 p.m. CAMBRIDGE, Mass., Nasdaq: RLAY) is scheduled to present at the 39th Annual J.P.

Small Molecule

The Premier Consulting Blog

JANUARY 31, 2023

Of note, this guidance is specific to small molecule pharmaceuticals; similar guidance for biologics can be found in the ICH’s S6(R1) Preclinical Safety Evaluation for Biotechnology-Derived Pharmaceuticals. URL: [link] The ICHS1 Regulatory Testing Paradigm of Carcinogenicity in Rats: Status Report 2021. Epub 2021 Nov 1.

Small Molecule

NIH Director's Blog: Drug Development

OCTOBER 11, 2022

For clinical researchers, click chemistry has emerged as a workhorse in drug discovery and the improved targeting of cancer chemotherapies and other small-molecule drugs. 2001, 40 (11), 2004–2021 [2] A stepwise huisgen cycloaddition process: Copper(I)-catalyzed regioselective “Llgation” of azides and terminal alkynes.

Research

New Drug Approvals

SEPTEMBER 10, 2024

g/mol 1929519-13-0 NBI-1065846 or TAK-041 Phase 2 (S)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide Zelatriazin ( NBI-1065846 or TAK-041 ) is a small-molecule agonist of GPR139. Cilia, Jackie; Hitchcock, Stephen (12 August 2021). Zelatriazin, C 18 H 15 F 3 N 4 O 3 , 392.3 1c00820.

Clinical Pharmacology

Drug Target Review

JUNE 12, 2023

The current version of Chemistry42 uses over 40 generative models, including generative autoencoders and generative adversarial networks as well as both structure-based and ligand-based drug design to generate and optimise de novo small molecules.

Metabolic Stability

The Pharma Data

JANUARY 31, 2021

1, 2021 /PRNewswire/ — AIkido Pharma Inc. and the results are expected to be released in Q2 2021. Convergent has identified certain small molecules that bind to PSMA, but at a different epitope than does CONV 01-?, and PSMA I&T in a dual therapy, which are anticipated to begin in February of 2021.

Small Molecule

The Pharma Data

JULY 18, 2021

Pfizer and BioNTech completed the rolling submission of the BLA in May 2021. On May 10, 2021, the FDA expanded the Emergency Use Authorization (EUA) of the Pfizer-BioNTech COVID-19 vaccine to include individuals 12 through 15 years of age.

Licensing