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A Visual Guide to Genome Editors

Codon

If the same virus invades the cell a second time, the gRNA’s spacer sequence will bind to the matching viral DNA sequence, then be cut by the Cas protein. Therapeutics Verve Therapeutics began the first clinical trial using base editors in 2022, with the goal of treating genetic contributors to heart disease.

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Phages could help to tackle antimicrobial resistance

Drug Target Review

Phage have been of interest to scientists as tools to understand fundamental molecular biology, as vectors of horizontal gene transfer and drivers of bacterial evolution, as sources of diagnostic and genetic tools, and as novel therapeutic agents. 2022 September 17 [2023 November 21]; 15(2022):4155-68.

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A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic

Broad Institute

The project is a collaboration between the Broad and the African Center of Excellence for Genomics of Infectious Diseases (ACEGID) at Redeemer’s University outside Lagos in Nigeria, where Happi is a professor of molecular biology and genomics. Through Sentinel, we are creating a world that is equitable.

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Repurposing FDA-approved drugs may help combat COVID-19

The Pharma Data

. “The SARS-CoV-2 vaccines target the spike protein, but this protein is under strong selection pressure and, as we have seen with Omicron, can undergo significant mutations,” said Joyce Jose, assistant professor of biochemistry and molecular biology, Penn State. 25) in the journal Communications Biology. .

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Breaking the Speed Limit on Cell Division

Codon

Cell (2022). coli divides every 20 minutes, then, because it spreads its molecular labor across anywhere from 10,000 to 100,000 ribosomes. The researchers chose to discard genes that encode virus-sensing machinery because the cells would be grown in a sterile laboratory environment. Credit: Thornburg Z.R. But it can improve.

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Alpaca nanobodies potently neutralize SARS-CoV-2 variants

The Pharma Data

Using electron cryo-microscopy, the researchers found that Fu2 naturally binds to two separate sites on the viral spike, thus inhibiting the virus’ ability to enter the host cell. 10, 2022, doi: 10.1038/s41467-021-27610-z. Science Advances, online March 25, 2022, doi: 10.1126/sciadv.abm0220. McInerney, Ben Murrell.

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Analysis Life Sciences Thank You Revised ICH viral safety guideline: NGS is in, animal use (mostly) out

Agency IQ

The final version includes some extensive updates to a 2022 draft revision, to include reduced use of animals in testing and development of these products. Prevention of viral contamination is especially important as it may not be apparent that cells have been contaminated with a virus using conventional detection methods.

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