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Automated red blood cell exchange: bridging treatment gaps in sickle cell disease care

Drug Target Review

Despite recent advances in gene therapy for sickle cell disease (SCD) , automated red blood cell exchange (aRBCX) remains a cornerstone therapy that plays a vital yet underutilised role in managing complications and enhancing quality of life for millions living with this devastating condition worldwide.

Disease 52
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Time for change: non-human primates in drug research

Drug Target Review

The FDA’s new roadmap In April 2025, the FDA announced a major regulatory shift with its plan to phase out the requirement for animal testing in the development of monoclonal antibodies and other drugs, when scientifically appropriate. This scarcity disrupts research timelines and limits the ability to replicate results across studies.

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F. William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce millions of doses of COVID-19 vaccines

Broad Institute

Chan School of Public Health, lauded Studier for how the technology has enabled strategies for infectious disease control. Nominations for the 2025 Merkin Prize are now open and will close on December 6, 2024, at 11:59 p.m. For further information on how to nominate for the 2025 Merkin Prize, please visit the prize website.

Vaccine 64
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SRP-001: redefining pain treatment with a safer, non-opioid analgesic

Drug Target Review

As a non-NSAID, it reduces adverse effects associated with these pain relief drugs, including kidney injury, GI gastritis/ulceration and blood pressure elevation, which can affect patients with cardiovascular disease and the elderly. We set out to improve health by developing a novel non-opioid that avoids potential abuse.

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Scientists discover network of cells and genes involved in Crohn’s disease complication

Broad Institute

By Allessandra DiCorato June 25, 2025 Credit: Xavier and Smillie labs Microscopy image shows intestinal tissue from a Crohn’s patient with fibrosis. In the new study, Xavier’s team analyzed 61 tissue samples from 21 patients with Crohn’s — from both routine biopsies and surgeries — and 10 people without inflammatory bowel disease.

Disease 111
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A Visual Guide to Genome Editors

Codon

Gray, in London to discuss the significance of her recovery at the Third International Summit on Human Genome Editing , described Casgevy as “a new beginning for people with sickle cell disease.” ” Despite its association with genome editing, 1 CRISPR didn’t start out as a tool for fighting genetic disease.

DNA 78
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Upcoming Fall 2025 Conference Highlights & Organizer Interviews

keypoint

Our Fall 2025 line-up features exciting topics across infectious disease, artificial intelligence and plant engineering, at venues from right here at home in Colorado all the way to Geneva, Switzerland!