Bioinformatics and Blog - Drug Discovery Digest

Case study: gget’s new Open Target module

The Open Targets Blog

JANUARY 30, 2025

This blog post is part of a series that will explore applications and expansions of the Open Targets informatics ecosystem, particularly the Open Targets Platform and Open Targets Genetics through conversations with our users. Where do you think the limits of this application are? Are you planning to do any additional work on this?

Bioinformatics

Bioinformatics Immune Response RNA Packaging

A Case Study of Addgene Bioinformatics

addgene Blog

MAY 25, 2023

Last summer, we posted about our bioinformatics quest , which led us to Seqera Labs , a company that provides open source workflow orchestration software for data pipeline processing (Nextflow), cloud infrastructure, and secure collaboration.

Bioinformatics

Case study: NCI’s Molecular Targets Platform

The Open Targets Blog

OCTOBER 31, 2023

This blog post is part of a series that will explore applications and expansions of the Open Targets informatics ecosystem, particularly the Open Targets Platform and Open Targets Genetics through conversations with our users.

Bioinformatics

Bioinformatics Engineering Clinical Trials Therapies

Case study: Extracting tidy data from Open Targets Genetics with Otargen

The Open Targets Blog

OCTOBER 24, 2023

This blog post is part of a series that will explore applications and expansions of the Open Targets informatics ecosystem, particularly the Open Targets Platform and Open Targets Genetics through conversations with our users. Their work was recently published in Bioinformatics.

Bioinformatics

Bioinformatics Packaging Pharmaceutical Companies Pharma Companies

Q&A with Lucy Sibbring, an intern with the Open Targets data team

The Open Targets Blog

FEBRUARY 29, 2024

With a background in biochemistry and bioinformatics, Lucy was interested in exploring how bioinformatics was applied to real-world healthcare data. I just graduated with a degree in Bioinformatics, and I was interested to see how the skills I learned could be applied.

International

International Bioinformatics RNA Disease

Three reflections from David Hulcoop's first year as Executive Director

The Open Targets Blog

AUGUST 13, 2024

Building and Sustaining I have huge admiration for the incredible teams at EMBL’s European Bioinformatics Institute and beyond who build and sustain knowledge resources for the community. I am really excited about bringing this to life with the team and where it will take us.

Bioinformatics

Bioinformatics Disease Treatment Drugs

AI in Drug Discovery - A Highly Opinionated Literature Review (Part II)

Practical Cheminformatics

JANUARY 8, 2024

Gotta be SAFE: A New Framework for Molecular Design [link] A blog post by Edward Williams from Terray Therapeutics introduced Contrastive Optimization for Accelerated Therapeutic Inference (COATI). In this paper, the authors then used 1.1 billion SAFE embeddings to train a generative model they call SAFE-GPT.

Drugs

Drugs Small Molecule Bioinformatics Packaging

Reaching cruising altitude: New discovery tools to target RNA

Dark Matter Blog

AUGUST 31, 2020

Analyzing these data required a sophisticated bioinformatics pipeline (the term for this specialized software), and our computational biologists worked alongside the wet lab scientists from the start to develop one.

RNA

RNA Small Molecule Bioinformatics Computational Chemistry

Meet Yakov Tsepilov, our new Genetics team leader

The Open Targets Blog

AUGUST 7, 2023

Following my interest in natural sciences, I moved to Novosibirsk (central Siberia) as soon as I was able, to study general biology, with a focus on statistical genetics and bioinformatics. I am an academic scientist through and through: I’ve been working in academia since university.

Bioinformatics

Bioinformatics Disease Science

We’re in this together: Achieve your goals faster with DrugBank on your side

DrugBank

MARCH 15, 2023

Scientific Support Christen Klinger Scientific Support Lead, Bioinformatics The Scientific Support team was created to help our users more easily move from ideation and exploration to implementation. We also author articles alongside Customer Success, research and write blogs , and host webinars.

Licensing

Licensing Licensing International Bioinformatics

Code breaking and the Human Genome Project

The Open Targets Blog

APRIL 25, 2023

Open Targets Blog Helena Cornu History of the Sanger Institute - Wellcome Sanger Institute Timeline of the Sanger Institute’s history Wellcome Sanger Institute References 1. Bioinformatics, Volume 13, Issue 4, August 1997, Pages 333–344 9. The Influence of ULTRA in the Second World War. Searls, D.B. Bletchley Park 10.

DNA

DNA Government Engineering Laboratories

Next Generation Sequencing (NGS): why is quantifying nucleic acids important? | BMG LABTECH

BMG Labtech

OCTOBER 4, 2023

2 DNA sequencing is also reliant on sample processing and DNA library preparation before sequencing as well as bioinformatics and data analysis after sequencing. These numbers reflect impressive developments in DNA sequencing technologies but in most cases represent the immediate costs of consumables on the sequencing instrument.

DNA

DNA RNA Bioinformatics Research

How we overhauled our literature processing pipeline using Named Entity Recognition

The Open Targets Blog

APRIL 19, 2022

To streamline this process, Shyamasree Saha and Santosh Tirunagari from the Europe PMC team at EMBL’s European Bioinformatics Institute began to investigate machine learning approaches. “From the beginning, we knew that deep learning would be the solution,” says Shyamasree.

Disease

Disease Bioinformatics FDA Production

In Silico Modeling Unveils a New Era in Rare Disease Drug Development

The Premier Consulting Blog

JUNE 18, 2023

BMC Bioinformatics 2020, 21(Suppl 17):527 [link] Author: Abie Ekangaki, PhD Vice President, Statistical Consulting References: [1] Successes and Opportunities in Modeling & Simulation for FDA. Accessed April 4, 2023, at: [link] [2] Russo et al.

Drug Development

Drug Development Disease Clinical Trials Drugs

Monkey Embryos Grow to 25 Days — No Womb Required

Codon

MAY 15, 2023

Bioinformatics. Bioinformatics. — Niko McCarty Disclosure: The views expressed in this blog are entirely my own and do not represent the views of any company or university with which I am affiliated. link ) VirPipe is a Python tool to detect viruses from sequencing data. Nucleic Acids Research.

DNA

DNA Bioinformatics Engineering Virus

Monkey Embryos Grow to 25 Days — No Womb Required

Codon

MAY 15, 2023

Bioinformatics. Bioinformatics. — Niko McCarty Disclosure: The views expressed in this blog are entirely my own and do not represent the views of any company or university with which I am affiliated. link ) VirPipe is a Python tool to detect viruses from sequencing data. Nucleic Acids Research.

DNA

DNA Bioinformatics Engineering Virus

Data Integration in Bioinformatics: Transforming Oncology Drug Discovery with Data Science

Crown Bioscience

JANUARY 23, 2025

The integration of data science and bioinformatics has become a cornerstone of modern oncology drug discovery. In this blog, we will explore the various ways in which data science is transforming oncology drug discovery, highlighting key technologies, applications, and future directions, with a focus on detailed, scientific insights.

Bioinformatics

Bioinformatics Science Drugs Therapies

An atlas of tissue-specific protein-protein associations helps to prioritise targets for drug discovery

The Open Targets Blog

MAY 6, 2025

This project was first conceived as part of the Open Targets research programme while Beltrao’s group was based at EMBL's European Bioinformatics Institute, then completed on his move to the ETH.

Bioinformatics

Bioinformatics Drugs Disease Regulations

Codon Digest: GPT-4 Controls a Robot

Codon

APRIL 16, 2023

BMC Bioinformatics. Read Thanks for reading, — Niko McCarty Email | Twitter | LinkedIn Disclosure: The views expressed in this blog are entirely my own and do not represent the views of any company or university with which I am affiliated. Read Deep learning of genomic contexts predicts protein co-regulation and function.

Engineering

Engineering DNA RNA Science

The Codon Guide to Synthetic Biology

Codon

AUGUST 10, 2023

Link ( See the blog by Mohammed AlQuraishi.) Link (See this blog about the synthetic yeast project.) Link The coming of age of de novo protein design , by Huang P-S. Nature (2016). Link Highly accurate protein structure prediction with AlphaFold , by Jumper J. Nature (2021). Genome Synthesis →Synthetic Genomes , by Zhang W.

DNA

DNA Cell Biology Molecular Biology Engineering

The Codon Guide to Synthetic Biology

Codon

AUGUST 10, 2023

Link ( See the blog by Mohammed AlQuraishi.) Link (See this blog about the synthetic yeast project.) Link The coming of age of de novo protein design , by Huang P-S. Nature (2016). Link Highly accurate protein structure prediction with AlphaFold , by Jumper J. Nature (2021). Genome Synthesis →Synthetic Genomes , by Zhang W.

DNA

DNA Cell Biology Engineering Molecular Biology

Drug Discovery Digest

Case study: gget’s new Open Target module

A Case Study of Addgene Bioinformatics

Trending Sources

Case study: NCI’s Molecular Targets Platform

Case study: Extracting tidy data from Open Targets Genetics with Otargen

Q&A with Lucy Sibbring, an intern with the Open Targets data team

Three reflections from David Hulcoop's first year as Executive Director

AI in Drug Discovery - A Highly Opinionated Literature Review (Part II)

Reaching cruising altitude: New discovery tools to target RNA

Meet Yakov Tsepilov, our new Genetics team leader

We’re in this together: Achieve your goals faster with DrugBank on your side

Code breaking and the Human Genome Project

Next Generation Sequencing (NGS): why is quantifying nucleic acids important? | BMG LABTECH

How we overhauled our literature processing pipeline using Named Entity Recognition

In Silico Modeling Unveils a New Era in Rare Disease Drug Development

Monkey Embryos Grow to 25 Days — No Womb Required

Monkey Embryos Grow to 25 Days — No Womb Required

Data Integration in Bioinformatics: Transforming Oncology Drug Discovery with Data Science

An atlas of tissue-specific protein-protein associations helps to prioritise targets for drug discovery

Codon Digest: GPT-4 Controls a Robot

The Codon Guide to Synthetic Biology

The Codon Guide to Synthetic Biology

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