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“Sam has an exceptional talent in software engineering, and his contributions reflect a deep understanding of both the technical and biological aspects required for bioinformatics tool development,” says Laura Luebbert, now a postdoctoral fellow in the Sabeti lab at the Broad Institute of MIT and Harvard and Harvard University.
1 The study reveals a novel bioinformatic approach and tool that holds the potential to empower researchers in designing vaccines capable of inducing a stronger immuneresponse. By selecting specific segments of proteins that elicit robust immune reactions, these vaccines could offer enhanced protection against diseases.
The genes unique to the severe long COVID patients were found to be associated with immune pathways such as myeloid differentiation, macrophage foam cells and lipid signalling pathways. She is a computational biologist with a background in bioprocess engineering and biotechnology.
A new paper in Biology Methods & Protocols, published by Oxford University Press, shows it may be possible to design vaccines that will induce a stronger immuneresponse to infecting pathogens, such as the virus causing COVID-19.
The journey from bench to bedside often spans over a decade, consuming billions of dollars in research and development (R&D) expenditure, with a significant probability of failure at each phase. In Silico Drug Repurposing Advances in bioinformatics and systems biology have fueled the rise of repurposing of in silico drugs.
A team led by researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has discovered and characterized one of these unexplored microbial defense systems. In the new study, the researchers wanted to know if the proteins work the same way in prokaryotes to defend against infection.
These neoantigens are identified by T cells of the immune system as foreign proteins and thus trigger an immuneresponse. Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Neoantigens are recognised as non-self and trigger an immuneresponse.
Our innate immune system evolved to clear genetically diverse pathogens and limit host toxicity, raising the possibility that it can produce similar effects in cancer. What aspects prompted this research direction? The preclinical results demonstrated significant immuneresponses and tumour regression.
Identifying a new or unexpected pathogen quickly, particularly when it occurs in conjunction with other, more common illnesses, is a key challenge for doctors, researchers, and public health professionals concerned with disease preparedness and biosecurity. At least nine laboratories outside the U.S. Cite: Allison Berke. DOI: [link]
Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. Skin microbes can trigger strong immuneresponses. AI + Bio *Emergent autonomous scientific research capabilities of large language models. BMC Bioinformatics. Please send me your feedback. Thanks for being here.
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