Vial

DECEMBER 5, 2023

It has become a fundamental tool for researchers to explore the complexities of genetic information and conduct genetic-informed drug development. Improvements in bioinformatics, robotics, liquid handling, and nucleic acid preparation will continue to transform NGS sequencing methods. Satam et al.

Clinical Trials

Drug Target Review

MAY 27, 2024

By identifying proteins that only interact with each other in cancer, but not normal tissues, we can really expand the repertoire of ADC therapeutics beyond monoclonal antibodies developed based solely on RNA expression profiles. His work has been published in many high-impact journals and presented at international oncology meetings.

Clinical Trials

BMG Labtech

OCTOBER 4, 2023

2 DNA sequencing is also reliant on sample processing and DNA library preparation before sequencing as well as bioinformatics and data analysis after sequencing. In contrast, long-read sequencing analyzes longer strands of DNA or RNA in one go without breaking the long strands into smaller fragments.

DNA

Broad Institute

MARCH 11, 2024

To guide the discussion, it is helpful to arrive at the meeting with the following information: What is the overall goal of the project? What other data have you collected from these samples (especially RNA-seq/scRNA-seq) Share any images you have of your samples H&E, immunofluorescence, ISH. What is the model system?

RNA

Codon

AUGUST 27, 2024

When doctors sequenced the DNA and RNA found in Alice’s blood and synovial fluid—the liquid that surrounds and lubricates joints—they found abnormally low levels of genes encoding iron-storing proteins and high levels of epidermal growth factor receptor RNA. At least nine laboratories outside the U.S.

DNA

PLOS: DNA Science

MAY 16, 2024

As soon as the initial RNA genome sequence of the pathogen that would be named SARS-CoV-2 was published, CDC and other organizations began developing diagnostic tests. ” This information can inform design of vaccines, therapeutics, and public health measures, which can help prevent epidemics from flaring up.

Virus

Codon

APRIL 16, 2023

But now, a new paper shows how to sequence up to six plasmids in a single sample, while retaining accurate information, using Bayesian statistics. BMC Bioinformatics. Read An RNA-based system to study hepatitis B virus replication and evaluate antivirals. Comparison of transformations for single-cell RNA-seq data.

Engineering

Codon

AUGUST 28, 2024

5 But it could match up to one of the threats in your reference database, so you opt to throw a battery of bioinformatics tools at it. BLAST is covered in every introductory bioinformatics course and the 1990 paper introducing has over 110,000 citations. Bioinformatic results from SecureDNA. Bioinformatic results from HMMScan.

DNA

Chemical Biology and Drug Design

FEBRUARY 5, 2025

Differentially expressed genes (DEGs) involved in luteolin and quercetin action that regulate adipogenic differentiation were identified using RNA sequencing (RNA-seq). Bioinformatic analyses were performed to identify potential target genes and pathways regulated by luteolin/quercetin during adipogenesis.

RNA