Remove Bioinformatics Remove Information Remove RNA
article thumbnail

Scientific workflow for hypothesis testing in drug discovery: Part 1

Drug Target Review

This includes verifying the experimental design and understanding how the data was generated whether it was from RNA sequencing, mass spectrometry, or other biological assays. Without this information, the interpretation of the dataset may be speculative or lead to inaccurate conclusions.

RNA
article thumbnail

What single cells are revealing about brain disorders

Drug Target Review

I got my eyes opened to molecular biology, bioinformatics, computational biology and these emerging fields at the time.” Xenium takes this further with in situ analysis at subcellular resolution, detecting RNA and protein molecules directly within tissues using high-resolution imaging.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Therapeutic Oligos 2025 Keynote Speakers Announced

Elrig

This second ELRIG meeting on Therapeutic Oligonucleotides brings together esteemed scientists from academia, industry, and other members of the drug discovery community to explore the discovery, validation, and targeting of oligonucleotide-based drug candidates, including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA).

RNA
article thumbnail

Fixing failed drugs: AI solutions for toxicity in drug discovery – part 2

Drug Target Review

” Hosseini-Gerami notes that modern multiomics approaches provide the following crucial context: RNA sequencing: “We can measure with RNA sequencing the genes that have gone up or down in expression because of that compound interaction.”

article thumbnail

What Makes a Mature Science

Codon

“Our Microscope informs us that the substance of Cork is altogether fill'd with Air,” he wrote, “perfectly enclosed in little Boxes or Cells distinct from one another.” We’ve known about base pairs, RNA, and DNA for decades, but we couldn't make full use of them because our tools were so poor.

article thumbnail

MIA: Noor Pratap Singh, RNA-Seq data using a tree-based framework; Primer: Rob Patro

Broad Institute

To address these challenges, we introduce a data-driven tree-based framework that incorporates uncertainty into RNA-seq data analysis. In the first part of the talk, I will discuss existing approaches for handling uncertainty and their limitations in RNA-seq data analysis before introducing TreeTerminus.

RNA
article thumbnail

Q&A with Lucy Sibbring, an intern with the Open Targets data team

The Open Targets Blog

  With a background in biochemistry and bioinformatics, Lucy was interested in exploring how bioinformatics was applied to real-world healthcare data. I just graduated with a degree in Bioinformatics, and I was interested to see how the skills I learned could be applied.