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MIA: Noor Pratap Singh, RNA-Seq data using a tree-based framework; Primer: Rob Patro

Broad Institute

To address these challenges, we introduce a data-driven tree-based framework that incorporates uncertainty into RNA-seq data analysis. In the first part of the talk, I will discuss existing approaches for handling uncertainty and their limitations in RNA-seq data analysis before introducing TreeTerminus.

RNA 52
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Therapeutic Oligos 2025 Keynote Speakers Announced

Elrig

This second ELRIG meeting on Therapeutic Oligonucleotides brings together esteemed scientists from academia, industry, and other members of the drug discovery community to explore the discovery, validation, and targeting of oligonucleotide-based drug candidates, including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA).

RNA 59
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Scientific workflow for hypothesis testing in drug discovery: Part 1

Drug Target Review

This includes verifying the experimental design and understanding how the data was generated whether it was from RNA sequencing, mass spectrometry, or other biological assays. Without this information, the interpretation of the dataset may be speculative or lead to inaccurate conclusions.

RNA 52
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Q&A with Lucy Sibbring, an intern with the Open Targets data team

The Open Targets Blog

  With a background in biochemistry and bioinformatics, Lucy was interested in exploring how bioinformatics was applied to real-world healthcare data. I just graduated with a degree in Bioinformatics, and I was interested to see how the skills I learned could be applied.

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Next Generation Sequencing (NGS) in Clinical Trials: Challenges and Opportunities

Vial

It has become a fundamental tool for researchers to explore the complexities of genetic information and conduct genetic-informed drug development. Improvements in bioinformatics, robotics, liquid handling, and nucleic acid preparation will continue to transform NGS sequencing methods. Satam et al.

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Leveraging ADCs in precision oncology strategy

Drug Target Review

By identifying proteins that only interact with each other in cancer, but not normal tissues, we can really expand the repertoire of ADC therapeutics beyond monoclonal antibodies developed based solely on RNA expression profiles. His work has been published in many high-impact journals and presented at international oncology meetings.

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Next Generation Sequencing (NGS): why is quantifying nucleic acids important? | BMG LABTECH

BMG Labtech

2 DNA sequencing is also reliant on sample processing and DNA library preparation before sequencing as well as bioinformatics and data analysis after sequencing. In contrast, long-read sequencing analyzes longer strands of DNA or RNA in one go without breaking the long strands into smaller fragments.

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