Vial

DECEMBER 5, 2023

Next-generation sequencing (NGS) has revolutionized scientific research and clinical genomics due to high-throughput multiplexing and shed light on genome structure, function, and dynamics. It has become a fundamental tool for researchers to explore the complexities of genetic information and conduct genetic-informed drug development.

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Clinical Trials Trials RNA Bioinformatics 52

Drug Target Review

MAY 24, 2024

2 AlphaFold 3 has been built to model DNA, RNA and smaller molecules (ligands). 5 Several major technology areas are not included above, such as cheminformatics and bioinformatics. Google DeepMind’s new AI can model DNA, RNA, and ‘all life’s molecules’. The latest exciting advancement is AlphaFold 3, which was just released.

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RNA DNA Bioinformatics Science 59

The Open Targets Blog

FEBRUARY 29, 2024

  With a background in biochemistry and bioinformatics, Lucy was interested in exploring how bioinformatics was applied to real-world healthcare data. I just graduated with a degree in Bioinformatics, and I was interested to see how the skills I learned could be applied.

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International Bioinformatics RNA Disease 57

Drug Target Review

MAY 27, 2024

Caris Discovery, the therapeutic research arm of Caris Life Sciences, was launched to address the paucity of novel oncology drug targets and is uniquely poised to discover first-in-class ADC targets. Can you discuss any recent advancements or breakthroughs in ADC-related research or development that Caris has been involved in?

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Clinical Trials Science Molecular Biology Bioinformatics 59

BMG Labtech

OCTOBER 4, 2023

2 DNA sequencing is also reliant on sample processing and DNA library preparation before sequencing as well as bioinformatics and data analysis after sequencing. In contrast, long-read sequencing analyzes longer strands of DNA or RNA in one go without breaking the long strands into smaller fragments.

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DNA RNA Bioinformatics Research 52

Broad Institute

MARCH 11, 2024

How is the research wing of the STP organized? What other data have you collected from these samples (especially RNA-seq/scRNA-seq) Share any images you have of your samples H&E, immunofluorescence, ISH. A comment on your comfort level with bioinformatics, images, and custom analysis.

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RNA Bioinformatics International Clinical Trials 52

Chemical Biology and Drug Design

JUNE 11, 2024

Using RNA-seq and through in vitro and in vivo studies, we determined that brusatol suppresses hepatocellular carcinoma progression by inducing ATF3-mediated ferroptosis. Therefore, our research revealed the biological effect of brusatol treatment and provided ATF3 as a novel therapeutic target and prognostic biomarker for HCC therapy.

RNA 100

RNA Bioinformatics Treatment Therapies 100

Drug Target Review

JULY 24, 2023

Researchers from Tokyo Tech’s World Research Hub Initiative conducted a study to investigate the regulation of gene expression in the apicoplast of the malaria parasite Plasmodium falciparum. He has shared his excitement about the study’s implications and how it opens up new avenues in malaria research.

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RNA Regulations Bioinformatics Laboratories 98

Chemical Biology and Drug Design

NOVEMBER 27, 2023

To clarify how A6 affected on MCF-7 cells, RNA-seq analysis was conducted to evaluate the whole genome effect of A6 on gene expression. Moreover, bioinformatic analysis and cell viability test showed A6 plays anticancer role by regulating Best1 and HIST1H2BJ. In addition, A6 induced apoptosis of MCF-7 cells.

Bioinformatics 100

Bioinformatics RNA Regulations Therapies 100

Broad Institute

AUGUST 11, 2022

A team led by researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has discovered and characterized one of these unexplored microbial defense systems. In the new study, the researchers wanted to know if the proteins work the same way in prokaryotes to defend against infection.

DNA 52

DNA Virus Immune Response Bioinformatics 52

Codon

AUGUST 27, 2024

Identifying a new or unexpected pathogen quickly, particularly when it occurs in conjunction with other, more common illnesses, is a key challenge for doctors, researchers, and public health professionals concerned with disease preparedness and biosecurity. At least nine laboratories outside the U.S. Cite: Allison Berke. DOI: [link]

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DNA Laboratories Hospitals Virus 109

Codon

MAY 15, 2023

🔥 Week in Review Biotech research highlights in under 5 minutes. For one of the studies , researchers collected blastocysts from cynomolgus monkeys, the long-tailed macaques native to southeast Asia. For another study , researchers made mouse models with prime editors encoded in the germline of various tissues.

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DNA Bioinformatics Engineering Virus 52

Codon

MAY 15, 2023

🔥 Week in Review Biotech research highlights in under 5 minutes. For one of the studies , researchers collected blastocysts from cynomolgus monkeys, the long-tailed macaques native to southeast Asia. For another study , researchers made mouse models with prime editors encoded in the germline of various tissues.

DNA 52

DNA Bioinformatics Engineering Virus 52

The Pharma Data

MARCH 20, 2021

Medicine in Oxford, Biogazelle, a biotechnology company in Ghent, and the Centre For Proteome Research at the University of Liverpool. Vandesompele is a research. Bioinformatics in the Faculty. Biogazelle, an innovative bioanalytical services company offering RNA and. research efforts in further understanding viral-host.

Laboratories 52

Laboratories Virus RNA Bioinformatics 52

Chemical Biology and Drug Design

APRIL 19, 2025

RNA sequencing and bioinformatic analyses were conducted to identify differentially expressed genes, followed by functional pathway enrichment analysis. Human cardiomyocyte AC16 cells were subjected to hypoxic conditions and treated with Dex and TPO. Cellular responses, including proliferation, apoptosis, and autophagy, were assessed.

Bioinformatics 100

Bioinformatics RNA Regulations Treatment 100

Chemical Biology and Drug Design

FEBRUARY 5, 2025

Differentially expressed genes (DEGs) involved in luteolin and quercetin action that regulate adipogenic differentiation were identified using RNA sequencing (RNA-seq). Bioinformatic analyses were performed to identify potential target genes and pathways regulated by luteolin/quercetin during adipogenesis.

RNA 100

RNA Bioinformatics Regulations Research 100

Codon

APRIL 16, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. AI + Bio *Emergent autonomous scientific research capabilities of large language models. BMC Bioinformatics. Read An RNA-based system to study hepatitis B virus replication and evaluate antivirals. Thanks for being here.

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Engineering DNA RNA Science 52

Codon

AUGUST 28, 2024

When the CDC contacted Harris to ask about the plague samples, Harris claimed that he was doing research for the CIA to stop an “imminent invasion from Iraq of super-germ-carrying rats.” Starting in October, researchers receiving funds from the U.S. Bioinformatic results from SecureDNA.

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DNA Bioinformatics Virus Government 103

Broad Institute

MAY 20, 2025

Scientists build cell line atlas of deadly cancers of the bile ducts and gallbladder By Leah Eisenstadt May 20, 2025 Breadcrumb Home Scientists build cell line atlas of deadly cancers of the bile ducts and gallbladder Researchers reveal new subtypes and potential therapeutic targets for biliary tract cancers, which lack effective treatments.

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Medical Schools Bioinformatics Treatment Hospitals 133

Codon

AUGUST 10, 2023

Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nucleic Acids Research (2010). FEMS Yeast Research (2015). Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. & Ellis T. Nature Communications (2020).

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DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nucleic Acids Research (2010). FEMS Yeast Research (2015). Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. & Ellis T. Nature Communications (2020).

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DNA Cell Biology Engineering Molecular Biology 52