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NGS is evolving: collaboration and tech lead the way

Drug Target Review

Their latest assay processes four to 24 libraries per batch and detects gene amplifications, fusions, deletions and other cancer biomarkers from both DNA and RNA inputs. Their latest assay processes four to 24 libraries per batch and detects gene amplifications, fusions, deletions and other cancer biomarkers from both DNA and RNA inputs.

RNA 92
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Scientific workflow for hypothesis testing in drug discovery: Part 1

Drug Target Review

This includes verifying the experimental design and understanding how the data was generated whether it was from RNA sequencing, mass spectrometry, or other biological assays. Figure 1: High-level workflow for early drug discovery Once the raw data has been gathered, the next step is to gain a thorough understanding of the data.

RNA 52
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What single cells are revealing about brain disorders

Drug Target Review

I got my eyes opened to molecular biology, bioinformatics, computational biology and these emerging fields at the time.” Xenium takes this further with in situ analysis at subcellular resolution, detecting RNA and protein molecules directly within tissues using high-resolution imaging.

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Therapeutic Oligos 2025 Keynote Speakers Announced

Elrig

This second ELRIG meeting on Therapeutic Oligonucleotides brings together esteemed scientists from academia, industry, and other members of the drug discovery community to explore the discovery, validation, and targeting of oligonucleotide-based drug candidates, including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA).

RNA 59
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What Makes a Mature Science

Codon

There are only 5 nucleotide bases behind all life: adenine (A), cytosine (C), guanine (G) and thymine (T) in DNA, and uracil (U) taking the place of thymine in RNA. We’ve known about base pairs, RNA, and DNA for decades, but we couldn't make full use of them because our tools were so poor. The same is true of biology.

Science 79
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Next Generation Sequencing (NGS) in Clinical Trials: Challenges and Opportunities

Vial

In 2017, the Food & Drug Administration (FDA) approved the first gene therapy for cancer and for inherited diseases, the first multiplex NGS panel for companion diagnostics (CDx), and the first drug targeting a genetic signature though not a disease. Fountzilas et al. Satam et al.

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Leveraging ADCs in precision oncology strategy

Drug Target Review

What role do ADCs play in Caris’ strategy for targeted cancer therapy, particularly in terms of patient-specific treatment plans? Patient specific treatment plans can be tailored to the cohorts that express the targets including feasibility assessment of combinations of our ADC targets with other lines of therapy.