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Time for change: non-human primates in drug research

Drug Target Review

7 This initiative forms part of a broader effort to modernise drug development and align regulatory expectations with emerging new approach methodologies (NAMs), including human cell-based assays, artificial intelligence models and organ-on-chip platforms. In silico toxicology: computational methods for predicting toxicity.

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Expanding Your Assay Specificity: Cisbio Joins PerkinElmer

PerkinElmer

The structure of HTRF reagents also makes assays highly resistant to most experimental conditions, and particularly well suited for cell-based assays. The post Expanding Your Assay Specificity: Cisbio Joins PerkinElmer first appeared on PerkinElmer Blog. Learn more about Cisbio here.

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Data checks

The ChEMBL-og

ChEMBL contains a broad range of binding, functional and ADMET type assays in formats ranging from in vitro single protein assays to anti proliferative cell-based assays. Some variation is expected, even for very similar assays, since these are often performed by different groups and institutes.

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Assays for the Future of Drug Discovery

PerkinElmer

Download the whitepaper to learn more about cell-based assays and what to consider as you design yours. The post Assays for the Future of Drug Discovery first appeared on PerkinElmer Blog. By assessing residence time, failure further down the drug discovery workflow can be avoided.

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Archbishop Ussher's guide to efficient selection of development candidates

Molecular Design

As the start of the post, I did mention some errors that you don’t want to be making if cheminformatics is your day job and regular readers of this blog will have already guessed that I’m talking about ligand efficiency (LE).

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Separating the Hype from the Hyperbole Surrounding FDORA’s Alternatives to Animal Testing under the FD&C Act

FDA Law Blog: Drug Discovery

The definition goes on to list potential options for such tests: cell-based assays, organ chips and microphysiological systems, computer modeling, other nonhuman or human biology-based test methods such as bioprinting, as well as animal tests. FDORA § 3209(a)(2).

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Applying ICH Q14 in Pharmaceuticals Part 1: The Application of Analytical Target Profile in Analytical Method Development

The Premier Consulting Blog

Part 2 of this blog series includes a more in-depth discussion on analytical procedure control strategy, and the benefits of the enhanced approach in the lifecycle management and post-approval changes of analytical procedures. Technology Selection Description of which technology was selected (HPLC, SDS-PAGE, cell-based assay, ELISA, etc.)