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The next phase of the multiomics evolution, powered by AI

Drug Target Review

The dynamic behaviour of RNA transcripts, the regulation and modification of proteins, the lipid composition of membranes, the structural organisation of cells and the spatial context of tissues all play critical roles in disease progression and therapeutic response.

RNA 71
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Q&A: One scientist’s bold vision to make on-demand treatments routine for life-threatening rare genetic diseases

Broad Institute

Related groups Liu Group Related news New CRISPR genome editing system offers a wide range of versatility in human cells Researchers extend power of gene editing by developing a new class of DNA base editors In May 2025, researchers announced that K.J. Some of these treatments, like K.J.’s,

Treatment 133
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Can Plants Really “See”?

Codon

Plastic leaves do not emit organic signals and contain no DNA, so any mimicry could imply some kind of primitive vision. Such vascular differences are governed by auxin, a plant hormone that regulates leaf venation and shape. Martin Bourdev is an engineer at Amgen Thousand Oaks supporting antibody drug production.

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A Visual Guide to Genome Editors

Codon

Certain CRISPR components can add short DNA sequences from the genomes of defeated viruses into the bacterium’s own genome, creating a type of protective “memory.” If the same virus invades the cell a second time, the gRNA’s spacer sequence will bind to the matching viral DNA sequence, then be cut by the Cas protein.

DNA 81
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Levers for Biological Progress

Codon

For example, cloning DNA molecules and inserting them into cells — a process required for basically all experiments in molecular biology — takes up to a week of work. Perhaps you’ve seen this chart before, which shows the falling costs of DNA sequencing over the last two decades. If we could get E.

DNA 132
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Improved prime editing system makes gene-sized edits in human cells at therapeutic levels

Broad Institute

The new method uses a combination of prime editing, which can directly make a wide range of edits up to about 100 or 200 base pairs, and newly developed recombinase enzymes that efficiently insert large pieces of DNA thousands of base pairs in length at specific sites in the genome.

DNA 144
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Targeting the immunotherapy potential of cytokines IL-12 and IL-18 with new advancements in protein engineering

Drug Target Review

At Alkermes , our interdisciplinary team of protein engineers, immunologists, pharmacologists, and analytical scientists is investigating the biology of several immunomodulatory cytokines including IL-12 and IL-18 to develop novel versions of these molecules with the goal of harnessing their therapeutic potential.