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A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report.
Buildup of a protein called filamentous actin, or F-actin, in the brain inhibits the removal of cellular wastes, including DNA, lipids, proteins and organelles. The resulting accumulation of waste diminishes neuronal functions and contributes to cognitive decline.
Also featured are the FKBP12 binding motif (light blue triangle), the DNA barcode (red double helix), and the combinatorial library element (red hexagon). Related groups Xavier lab Over the past two decades, large genetic studies have linked tens of thousands of DNA variants to thousands of human traits and diseases.
Research by Markets and Markets projects the market to grow from $12.13 1 Emergen Research attributes this to the advantages of high-throughput sequencing technologies and declining sequencing costs. 2 This trend reflects the increasing demand for genomic sequencing in research, clinical diagnostics and other applications.
Researchers at the Broad Institute of MIT and Harvard and Cyrus Biotechnology have now engineered two CRISPR nucleases, Cas9 and Cas12, to mask them from the immune system. The study was led by Feng Zhang , a core institute member at the Broad and an Investigator at the McGovern Institute for Brain Research at MIT.
Combining genomics with transcriptomics, proteomics, metabolomics, spatial profiling and cellular imaging, will enable researchers to move beyond single-variable analysis and begin to see the biological system as a whole. Enter multiomics Multiomics is designed to solve this problem by observing multiple molecular layers simultaneously.
Researchers from around 29 universities and institutions across North America have teamed up to create a large, versatile, and effective arsenal of new biological tools that will play a critical role in the battle against brain disease. Ben-Simon et al.) and striatum ( Hunker et al. Ben-Simon et al.) and striatum ( Hunker et al.
The piperazine moiety is used as the building block of several molecules and is reported to have the ability to inhibit the cell cycle (G1/S phase), inhibit angiogenesis, and interact with DNA.
By directing Cas-mediated DNA cleavage to specific genomic targets and utilizing intrinsic DNA repair processes, this system can produce site-specific gene modifications. This goal is achieved through an RNA-guided procedure.
An ancient RNA-guided system could simplify delivery of gene editing therapies By Corie Lok February 27, 2025 Breadcrumb Home An ancient RNA-guided system could simplify delivery of gene editing therapies The programmable proteins are compact, modular, and can be directed to modify DNA in human cells.
Early CRISPR applications were often limited by the low editing efficiency of homology-directed repair (HDR) , the pathway for resolving DNA double-strand breaks (DSBs) preferred by researchers. Compared to non-homologous end joining (NHEJ) , HDR occurs at a relatively low frequency, especially in nondividing cells.
But what if, instead, researchers could create bespoke enzymes from the ground up? The researchers generated 10,000 potential designs for serine hydrolases, each built around a fixed catalytic site composed of serine, histidine, and aspartate. They synthesized DNA encoding each protein variant, expressed the proteins in E.
Researchers at the Broad Institute Ben Neale and Mark Daly are co-leading the study, which allows people across the US to sign up to have their DNA analyzed as part of this effort. Neale is a core institute member and co-director of the Stanley Center for Psychiatric Research at the Broad Institute.
“Unlike gene editing, which makes irreversible DNA changes, engineered tRNA allows for controlled, reversible interventions,” Michelle highlights. “A A single tRNA therapeutic could treat multiple diseases caused by the same mutation.”
Base editing, which Lius team developed in 2016, is a gene editing technique that directly converts an individual DNA base pair into a different base pair. During his doctoral research at University of California Berkeley, Liu initiated the first general effort to expand the genetic code in living cells.
This dual role enables him to bridge research and clinical practice, ensuring scientific innovation is directly informed by patient care. “As Delpassand’s clinical experience plays a key role in shaping the research pipeline. Shared goals in cancer drug discovery For all its internal capabilities, RMX does not operate in isolation.
At the centre of this shift is 10x Genomics – a company building tools that enable researchers to study individual cells and their gene activity, both in isolation and in their original spatial context. Together, these tools give researchers a detailed view of how cells behave, where they are and how they contribute to health or disease.
To make the MM-like score more clinically accessible, the team is developing a test based on liquid biopsies instead of bone marrow biopsies to collect DNA. Funding Support for this study was provided by the Multiple Myeloma Research Foundation, the Dr. Miriam and Sheldon G.
For a contract research organization (CRO), it can play an integral role in increasing the quality and speed of drug development while reducing costs, repetitive manual tasks, and human error. Tags Bioanalysis Preclinical Research Weight 15
Guardant Health DNA minimal residual disease clinical trial Resource Type Whitepaper Guardant Health Listing Logo.png Tue, 06/24/2025 - 12:43 Biotech Clinical Data Diagnostics Research Landing Page Url [link] Byline Sponsored by: Guardant Health
Cold sore-causing HSV-1 doesn't just hijack cells it reconfigures the entire architecture of our DNA to aid its invasion. Researchers discovered that it actively reshapes the 3D structure of the human genome within hours of infection, using host enzymes like topoisomerase I to gain access to crucial genetic machinery.
Related groups Liu Group Related news New CRISPR genome editing system offers a wide range of versatility in human cells Researchers extend power of gene editing by developing a new class of DNA base editors In May 2025, researchers announced that K.J. Some of these treatments, like K.J.’s,
Researchers must characterize the anti-drug-antibody (ADA) response in preclinical and clinical studies and report any ADA-positive samples as a risk-based approach. An oligonucleotide is a short strand of nucleotides, the building blocks of DNA or RNA, used in genetic research and therapy.
In 2016, researchers František Baluška and Stefano Mancuso suggested that ocelli could also explain Boquila ’s uncanny shape-shifting ability, positing that these “tiny eyes” may actually be capable of sight. Here is a time-lapse video of a plant moving in response to changing sunlight.)
What started 28 years ago as a meeting for academic researchers has evolved into a dynamic, cross-disciplinary hub for the entire cell and gene therapy ecosystem. Over just a few short days, I connected with researchers, sponsors, and partners to talk shop: industry trends, regulatory shifts, and scientific advances.
2] An overview of the 3Rs The FDA and other global regulatory health authorities have long embraced the 3Rs of animal research (replace, reduce, and refine). 6] ICH Harmonised Guideline M7(R2) (2023): Assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals to limit potential carcinogenic risk.
Clinical Trials: Pritelivir is currently in phase II clinical trials, with ongoing research into its effectiveness and safety. Research and Development: Pritelivir is being developed by AiCuris Anti-infective Cures, building upon research from Bayer. First-line treatment is generally acyclovir or its prodrug valacyclovir.
DNA is the calling card of life. In and on our bodies, traces of DNA sequences other than our own announce the presence of many microbes, our microbiome. “It seemed like it would be hard to get intact large fragments of DNA from the air, but that’s not the case. We’re finding a lot of informative DNA.
DNA from a skull found at Newgrange once sparked theories of a royal incestuous elite in ancient Ireland, but new research reveals no signs of such a hierarchy. Instead, evidence suggests a surprisingly egalitarian farming society that valued collective living and ritual.
The detailed DNA map shows this ancient creature evolved differently from its spider and scorpion cousins, lacking genome duplications seen in those species. With new gene activity data, researchers now have a powerful tool to explore how sea spiders grow, regenerate, and evolved into some of the oddest arthropods on Earth.
DNA sequencing with the Blended Genome Exome (BGE) By Rose Circeo June 12, 2025 Breadcrumb Home DNA sequencing with the Blended Genome Exome (BGE) The Primer on Medical and Population Genetics is a series of informal weekly discussions of basic genetics topics that relate to human populations and disease.
But thanks to AI-powered genetic research, scientists have revealed a far more entangled history. Their legacy lives on in our DNA, reshaping our understanding of what it means to be human. These revelations suggest that Neanderthals never truly disappeared — they were absorbed.
On the last day of February every year is Rare Disease Day , a dedicated day to celebrate the rare disease community, including patients, families, caregivers, clinicians, researchers, regulators, and more. The goal is to build community, share ideas and resources, and advance research and innovation.
New research is shaking up our understanding of evolution by revealing that some species may not evolve gradually at all. Their entire genome broke into pieces and was randomly reassembled an event so extreme it stunned researchers.
Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types.
Issue 07 launches this Monday with a marvelously researched essay on the uncertain origins of aspirin. The event hosts will provide snacks and drinks, and the winning teams will get signed copies of our DNA books and free hats. This essay makes a strong case for moving beyond impressionistic research. Please RSVP to join.
According to new research next-generation DNA sequencing (NGS) -- the same technology which is powering the development of tailor-made medicines, cancer diagnostics, infectious disease tracking, and gene research -- could become a prime target for hackers.
Because genes encode proteins, analyzing the proteins at the site of action – skin – can reflect what’s going on at the DNA level. To identify the gene–environment interactions behind eczema, the researchers analyzed data from 16 European studies. What is the mechanism?
With GROVER, a new large language model trained on human DNA, researchers could now attempt to decode the complex information hidden in our genome. GROVER treats human DNA as a text, learning its rules and context to draw functional information about the DNA sequences.
With their 'T-REX' method, researchers developed a glassy, amber-like polymer that can be used for long-term storage of DNA, such as entire human genomes or digital files such as photos.
Researchers have demonstrated a technology capable of a suite of data storage and computing functions -- repeatedly storing, retrieving, computing, erasing or rewriting data -- that uses DNA rather than conventional electronics. Previous DNA data storage and computing technologies could complete some but not all of these tasks.
Waves of human migration across Europe during the first millennium AD have been revealed using a more precise method of analysing ancestry with ancient DNA, in research led by the Francis Crick Institute.
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