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Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Science Daily: Pharmacology News

A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report.

DNA 305
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Cold sore virus hijacks human genome in 3D--and scientists found its weak spot

Science Daily: Pharmacology News

Cold sore-causing HSV-1 doesn't just hijack cells it reconfigures the entire architecture of our DNA to aid its invasion. Stunningly, blocking this single enzyme shuts the virus down completely.

Virus 211
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Something in the Air – Environmental DNA Update

PLOS: DNA Science

DNA is the calling card of life. In and on our bodies, traces of DNA sequences other than our own announce the presence of many microbes, our microbiome. “It seemed like it would be hard to get intact large fragments of DNA from the air, but that’s not the case. . We’re finding a lot of informative DNA.

DNA 56
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An ancient RNA-guided system could simplify delivery of gene editing therapies

Broad Institute

An ancient RNA-guided system could simplify delivery of gene editing therapies By Corie Lok February 27, 2025 Breadcrumb Home An ancient RNA-guided system could simplify delivery of gene editing therapies The programmable proteins are compact, modular, and can be directed to modify DNA in human cells. Lisa Yang and Hock E.

RNA 66
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Researchers engineer in vivo delivery system for prime editing, partially restoring vision in mice

Broad Institute

Williams January 8, 2024 Credit: Susanna Hamilton, Broad Communications Researchers have developed virus-like particles that can deliver gene-editing cargo to cells, including those in the mouse brain. Prime editing, described in 2019 by Liu’s group, can make longer and more diverse types of DNA changes than other types of editing.

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Scientists create next generation of tools in battle against brain disease

Broad Institute

The team has successfully created over 1000 of them, and each consist of: a harmless adeno-associated virus (or AAV) that acts like a shuttle capable of transporting specially designed DNA into the cell; a segment of DNA (an enhancer) that acts like an activation switch to mark or trigger a change in how the cell functions.

Disease 72
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A virus that infected the first animals hundreds of millions of years ago has become essential for the development of the embryo

SCIENMAG: Medicine & Health

Viral genetic material was integrated into the genome of the first multi-cellular beings and is still in our DNA today. Researchers from the CNIO (Spanish National Cancer Research Centre) describe now in the journal Science […]

Virus 69