DrugBank

MAY 15, 2024

The binding pockets on KRAS are shallow and polar , not ideal for the kinds of interactions needed for strong, effective drug binding. In fact, it's one of the most exciting areas in drug research today. One approach is to look beyond the traditional drug molecule.

Small Molecule 98

Small Molecule Molecular Biology Drugs Disease 98

Vial

MAY 20, 2024

In the field of clinical research , this pipeline can be broken down into several stages and processes specifically designed to rigorously validate the safety and efficacy of new drugs and treatments. The two broadest categories of drug development can be separated into the preclinical and clinical research stages.

Clinical Research 52

Clinical Research Clinical Trials Research Trials 52

Advarra

AUGUST 16, 2022

The Orphan Drug Act of 1983 was instrumental in changing the number of orphan drugs approved in the U.S. The law established the Office of Orphan Products Development , providing financial incentives for pharmaceutical companies to develop orphan drugs and making it more viable to invest in orphan drug research and development.

Disease 52

Disease Clinical Trials FDA Approval FDA 52

DrugBank

FEBRUARY 12, 2025

The pharmaceutical industry grapples with the persistent challenge of high attrition rates and escalating costs inherent in drug development. This necessitates exploring alternative strategies to expedite drug discovery and optimize resource allocation.

Cell Based Assays 52

Cell Based Assays Drugs Pharmacokinetics Disease 52

The Pharma Data

NOVEMBER 10, 2020

Dr. Liu shared his over 30 years of R&D experience in drug development both in the global pharmaceutical companies and world renowned scientific research institutions. Yong-Jun Liu , the newly appointed President of Innovent also made his first public appearance on the virtual R&D day.

Biosimilars 52

Biosimilars Clinical Trials International Clinical Development 52

The Pharma Data

MAY 19, 2023

HIGH SCHOOL SCIENTISTS AND ENGINEERS WIN NEARLY $9 MILLION AT THE REGENERON INTERNATIONAL SCIENCE AND ENGINEERING FAIR 2023 Regeneron Pharmaceuticals, Inc. The competition featured over 1,600 young scientists representing 49 states and 64 countries across the world. Kaitlyn Wang won first place and received the $75,000 George D.

Engineering 52

Engineering International Science Virus 52

Agency IQ

JUNE 9, 2023

What will the orphan drug market exclusivity haircut mean for industry? Just over a month ago, the European Commission released its proposal for the new pharmaceutical directive and regulation. The average annual growth in non-orphan pharmaceutical expenditure in the same period was only 3%. member states.

Marketing 40

Marketing Regulations Biosimilars Drugs 40

Agency IQ

AUGUST 11, 2023

BY KARI OAKES AUG 7, 2023 10:20 PM CDT Quick background on nitrosamines in pharmaceutical products Nitrosamines are a large and diverse class of chemicals, with more than 300 different structurally distinct species known today. In 2018, NDMA was first detected in the active pharmaceutical ingredient (API) for valsartan, a blood pressure drug.

FDA 40

FDA Science Production Regulations 40

Agency IQ

NOVEMBER 27, 2023

In recent years, nitrosamines, and most commonly N-nitrosodimethylamine (NDMA), have been found in finished drug products in several classes, including medicines used for diabetes, hypertension, acid reflux, and smoking cessation. [ In a study of more than 12,000 small molecule drugs , researchers found 40.4%

Regulations 40

Regulations Production FDA Marketing 40

The Pharma Data

JUNE 11, 2025

The Broad Institute, one of the world’s leading biomedical research centers, brings deep capabilities in genomics, systems biology, and computational analytics. Bayer contributes decades of experience in pharmaceutical R&D, encompassing drug design, medicinal chemistry, and clinical development for both small molecules and biologics.

Drug Research 40

Drug Research Research Small Molecule Drugs 40

Drug Target Review

OCTOBER 26, 2023

Consequently, an increasing number of academic researchers and companies are entering this field. Much like models such as ChatGPT that showcase AI’s vast capabilities in natural language processing and knowledge understanding, AI large language models (LLM) also hold immense potential in life sciences and pharmaceuticals.

Engineering 105

Engineering Virus Therapies Immune Response 105

Agency IQ

AUGUST 2, 2024

Positive August 2024 Eurneffy (epinephrine) Ars Pharmaceuticals Irl Limited Positive August 2024 MResvia (Respiratory Syncytial Virus mRNA vaccine) Moderna Biotech Spain S.L. Positive August 2024 Balversa (erdafitinib) Janssen-Cilag International N.V.

Regulations 40

Regulations Clinical Trials Production Trials 40

Codon

JANUARY 21, 2024

People are hesitant to do this because it's not a particularly flashy disease to research, nor is this population the focus of major pharmaceutical companies. So if you're a researcher, you can pour your heart and soul into a hepatitis C vaccine, and it probably won't ever get tested. So you have to do a field study.

Vaccine 130

Vaccine Trials Disease Treatment 130

Drug Target Review

FEBRUARY 11, 2025

Drug development: addressing complexity and success rates Drug development is a complex and expensive process, requiring multidisciplinary expertise and high-risk financial investments. The major hurdles that pharmaceutical companies face are long lead times, high costs and a low probability of success (PoS).

Drug Development 59

Drug Development Bioinformatics Drugs Small Molecule 59