Covalent Modifiers

JUNE 5, 2025

Gibae Kim, R. Justin Grams, and Ku-Lung Hsu Chemical Reviews 2025 DOI: 10.1021/acs.chemrev.5c00001 Targeting intractable proteins remains a key challenge in drug discovery, as these proteins often lack well-defined binding pockets or possess shallow surfaces not readily addressed by traditional drug design. Covalent chemistry has emerged as a powerful solution for accessing protein sites in difficult to ligand regions.

Drugs

Codon

JUNE 5, 2025

It was Victoria Gray’s first time in London and, despite a sleepless plane ride across the Atlantic Ocean, she wasn’t about to skip sightseeing. While crossing Trafalgar Square, Gray paused briefly to reflect on her experience. “I would never have been able to walk this long before,” she told a NPR reporter. “I feel like I got a second chance.” Four years earlier, in 2019, Gray had become the first patient with sickle cell anemia — a genetic disorder tha

DNA

Drugs.com

JUNE 5, 2025

THURSDAY, June 5, 2025 Having a family dog might decrease a babys risk of developing eczema later in childhood, a new evidence review says.Specifically, exposure to canines appears to influence a childs genetic risk of eczema, by blunting skin i.

BioPharma Drive: Drug Pricing

JUNE 5, 2025

A deal worth up to $712 million with the China-based biotech gives Cullinan T cell engagers aimed at BCMA and CD19, two targets of interest in inflammatory conditions.

Disease

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Clinical Trials

Predictive Oncology

JUNE 5, 2025

Following the generation of successful results with the University of Michigan through the ACE program, Predictive Oncology is now actively calling for submissions for a new cohort of compounds to be tested in Q4 2025. ACE program participation is offered exclusively to academic institutions and provides access to the POAI proprietary active ML/AI and biobank of primary patient dissociated tumor cells (DTCs) at no-cost, with data and IP protection provided to participants.

Packaging

Drug Target Review

JUNE 5, 2025

Despite recent advances in gene therapy for sickle cell disease (SCD) , automated red blood cell exchange (aRBCX) remains a cornerstone therapy that plays a vital yet underutilised role in managing complications and enhancing quality of life for millions living with this devastating condition worldwide. Dr Aaron Haubner, Senior Manager of North America Medical Affairs and Market Access at Terumo Blood and Cell Technologies , reveals that while promising new treatments emerge, urgent partnerships

Disease

Perficient: Drug Development

JUNE 5, 2025

In the fast-paced world of software development, automated API testing is no longer optionalit’s essential. If you’re looking for a sleek, intelligent tool to streamline your API testing workflow, Postbot might be exactly what you need. In this blog post, we’ll explore what Postbot is, its core features, and how you can start using it today.

Production

Drugs.com

JUNE 5, 2025

THURSDAY, June 5, 2025 People who get weight-loss surgery experience an improvement in their mental health, but not because of the weight they lose, a new study says.Rather, these patients face much less societal stigma over their weight, and i.

New Drug Approvals

JUNE 5, 2025

Gamcemetinib CAS 1887069-10-4 CC-99677 , OS2IR8TV1O Molecular Weight 469.94 Formula C 22 H 20 ClN 5 O 3 S (10 R )-3-[[2-Chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-8 H -[1,4]diazepino[5′,6′:4,5]thieno[3,2- f ]quinolin-8-one (ACI) (10 R )-3-{[2-chloro-5-(ethoxymethyl)pyrimidin-4-yl]oxy}-10-methyl-9,10,11,12-tetrahydro-8 H -[1,4]diazepino[5′,6′:4,5]thieno[3,2- f ]quinolin-8-one BMS 986371 BMS-986371 CC 99677 CC-99677 (R)-3-((2-Chloro-5-(ethoxymethyl)pyrimidin-4-yl)ox

Cell Based Assays

Collaborative Drug

JUNE 5, 2025

A practical guide to selecting the right ELN or LIMS for early-stage drug discovery, focusing on usability, structure search, and scalability.

Drugs

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

thought leadership

JUNE 5, 2025

So, you're thinking about Technology Transfers (i.e., TT, Tech Transfer)? Who can blame you? There has been a significant amount of news recently regarding tariffs and the potential for bringing manufacturing back to the United States. If your manufacturing is outside the United States, then this news will certainly keep Tech Transfer on your mind. Of course, technology transfers occur for other reasons.

Compliance

Drug Patent Watch

JUNE 5, 2025

"The Patent Expiration Effect: How Big Pharma's Weak Spots Become Your Next Big Score When a pharmaceutical giant's patent expires, it's like throwing a lifeline to savvy investors. The waters are chock-full of opportunities to capitalize on the disruption. In our latest report, we dive into the world of patent expirations and reveal the top targets for predatory investment.

Pharmaceuticals

Perficient: Drug Development

JUNE 5, 2025

We are proud to announce that Perficient has officially achieved Premier Partner status with Snowflake, a recognition that underscores our strategic commitment to delivering transformative data and AI solutions in the cloud. This milestone marks a significant step forward in our longstanding partnership with Snowflake. Advancing from Select to Premier Partner is more than a status updateits a clear reflection of our proven expertise, consistent delivery of value-driven outcomes, and dedication

Fierce BioTech

JUNE 5, 2025

Find a faster route to Europe at BIO with Sciensus expert team. With 30+ years experience, Sciensus helps biopharma navigate Europes healthcare complexity to bring therapies to patients. From early access and decentralised trial support to real-world evidence and in-home care, we provide the infrastructure and insight to accelerate access and unlock commercial value.

Therapies

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

JUNE 5, 2025

Harvard and PSI scientists have managed to freeze normally fleeting quantum states in time, creating a pathway to control them using pure electronic tricks and laser precision.

The Pharma Data

JUNE 5, 2025

A Life-Course Approach to Immunization: Prioritizing Vaccination at Every Age to Unlock the Full Potential of Lifelong Health In a striking demographic milestone, the global population is undergoing a historic transformation: for the first time ever, the number of adults over the age of 65 now exceeds that of children under the age of five. By 2030, nearly one billion people will fall into the 65-and-older age group, marking a seismic shift in age distribution across the world.

Vaccine

Drugs.com

JUNE 5, 2025

THURSDAY, June 5, 2025 — More American teenagers now use the weight-loss drug Wegovy, as doctors and families grow more comfortable with the treatment. But experts say access is still limited, and more research on its long-term safety in.

Doctors

Fierce BioTech

JUNE 5, 2025

When bioinformatician Dan Morgan finished his Ph.D. | Researchers unaffiliated with an academic library can find accessing scientific papers pricy. But some have found a way to address the problem.

Research

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

The Pharma Data

JUNE 5, 2025

WHO Sounds Alarm on Imminent Collapse of Gaza Health System as Nasser and Al-Amal Hospitals Face Shutdown The World Health Organization (WHO) has issued an urgent warning about the imminent collapse of the healthcare system in the Gaza Strip, emphasizing that two of the last functioning hospitals— Nasser Medical Complex and Al-Amal Hospital in Khan Younis—are on the brink of becoming non-functional.

Hospitals

Fierce BioTech

JUNE 5, 2025

Global trade uncertainty and evolving tariff policies are shifting how bioscience companies view their supply chains. | Global trade uncertainty and evolving tariff policies are shifting how bioscience companies view their supply chains.

FDA Law Blog: Biosimilars

JUNE 5, 2025

By Jennifer D. Newberger — We have written many posts ( here , here , here , and more) about the impact of the reductions in force (RIFs) on various activities across FDA. One area where the RIFs are beginning to have an impact is with respect to Small Business Determination (SBD) requests submitted to CDRH. The Office of Management, which was eliminated in the April 1 RIF, was responsible for processing these requests, and generally did so within 60 days of receipt.

Production

Perficient: Drug Development

JUNE 5, 2025

AI Isn’t the Future It’s Already Here Sales, service, and marketing teams face increasing pressure to do more with less, and artificial intelligence is expected to play a pivotal role in meeting that challenge. Yet despite the rapid adoption of generative AI (GenAI), many organizations are struggling to turn that excitement into real business value.

Marketing

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

The Pharma Data

JUNE 5, 2025

Anne-Catherine Berner Appointed as New Chair of Grifols: A Strategic Move Toward Long-Term Value Creation and Governance Excellence Grifols a global leader in the development of plasma-derived therapies and diagnostic technologies, has announced a key leadership transition following its 2025 Annual Shareholders’ Meeting. Anne-Catherine Berner has officially been appointed as the new non-executive Chair of the Board, succeeding Thomas Glanzmann, who chose not to seek re-election after a distingui

Government

Drugs.com

JUNE 5, 2025

THURSDAY, June 5, 2025 — U.S. Health and Human Services Secretary Robert F. Kennedy Jr. has ordered a fresh safety review of mifepristone, a drug commonly used in medication abortions. He asked Dr. Marty Makary, commissioner of the U.S. Food.

Drugs

LifeSciVC

JUNE 5, 2025

By Arthur Tzianabos, CEO of Lifordi Immunotherapeutics, as part of the From The Trenches feature of LifeSciVC Its easy to jump on the negative bandwagon these days when news in our world and industry is focused on doom & gloom. In biotech, headlines and daily conversations lean heavily toward company layoffs, shutdowns, pipeline pare-backs, regulatory setbacks, depressed valuations, and what feels like impossible situations.

Science

Drugs.com

JUNE 5, 2025

THURSDAY, June 5, 2025 An afternoon snooze might seem appealing to middle-aged folks and seniors, but these naps could carry a high cost.People with certain types of napping patterns have a greater risk of an early death, researchers are slated t.

Research

BioPharma Drive: Drug Pricing

JUNE 5, 2025

Skip to main content CONTINUE TO SITE ➞ Dont miss tomorrows biopharma industry news Let BioPharma Dives free newsletter keep you informed, straight from your inbox. Daily Dive M-F Commercialization Weekly Every Wednesday Gene Therapy Weekly Every Thursday Emerging Biotech Weekly Every Tuesday By signing up to receive our newsletter, you agree to our Terms of Use and Privacy Policy.

FDA

Drugs.com

JUNE 5, 2025

THURSDAY, June 5, 2025 As many as 1 in 5 women say theyve sought care at fake medical clinics with an anti-abortion agenda, a new study says.Between 12% to 20% of 18- to 44-year-old women in four states Arizona, Wisconsin, Iowa and New Jersey .

Drugs.com

JUNE 5, 2025

THURSDAY, June 5, 2025 Jail time has a huge effect on both an individuals and a communitys long-term health, even after their release, a new study says.People serving time are 39% more likely to die than those not in jail or prison, researchers.

Research

Drugs.com

JUNE 5, 2025

THURSDAY, June 5, 2025 — Some packages of organic ground beef sold at Whole Foods stores across the country may be contaminated with E. coli, federal officials have warned. The U.S. Department of Agriculture's Food Safety and Inspection.

Packaging