Tue.Apr 22, 2025

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Researchers use machine learning to engineer 'bespoke enzymes' for gene editing

Science Daily: Pharmacology News

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions -- but there is always room for improvement. A new paper showcases the power of scalable protein engineering combined with machine learning to boost progress in the field of gene and cell therapy. In their study, authors developed a machine learning algorithm -- known as PAMmla -- that can predict the properties of about 64 million genome editing enzymes.

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Promises Made Simple: Understanding Async/Await in JavaScript

Perficient: Drug Development

JavaScript is single-threaded. That means it runs one task at a time, on one core. But then how does it handle things like API calls, file reads, or user interactions without freezing up? Thats where Promises and async/await come into play. They help us handle asynchronous operations without blocking the main thread. Lets break down these concepts in the simplest way possible so whether you’re a beginner or a seasoned dev, it just clicks.

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Partnering with Eli Lilly to Empower the Biomedical Workforce

keypoint

Keystone Symposia was founded on the idea of bringing academic and industry scientists together to accelerate translational advances that cannot be achieved without their combined expertise and resources. As such, we have a long history of partnership with industry leaders with the shared goal of integrating basic science discovery and innovation into drug development efforts to yield novel and improved targeted treatment strategies.

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The Russian Pharmaceutical Industry: Strategic Evolution, Key Players, and Technological Innovation

Drug Patent Watch

"The Russian Pharmaceutical Industry: A Strategic Evolution Unfolding As the global pharmaceutical landscape continues to shift, one country is making a bold move: Russia. With a growing focus on domestic production and technological innovation, the Russian pharmaceutical industry is poised for significant growth. In this in-depth report, we dive into the key players, strategic evolution, and technological advancements driving the industry forward.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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The Future of Remote Patient Monitoring in Decentralized Clinical Trials

Crucial Data Solutions

The Evolution of Remote Patient Monitoring in Clinical Trials Remote patient monitoring (RPM) has come a long way from the. The post The Future of Remote Patient Monitoring in Decentralized Clinical Trials appeared first on Crucial Data Solutions.

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Integrating Clinical Trials and 505(b)(2) Pathway into Pharmaceutical Portfolio Management and Generic Launch Strategy

Drug Patent Watch

"Game Changer Alert: Are You Leaving Millions on the Table? As a pharmaceutical executive, you know the importance of staying ahead of the competition. But are you overlooking a crucial aspect of your generic launch strategy? I recently came across a fascinating article from @DrugPatentWatch that highlights the untapped potential of integrating clinical trials and the 505(b)(2) pathway into your pharmaceutical portfolio management.

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Roche, answering tariff threat, pledges $50B to US drug production

BioPharma Drive: Drug Pricing

The big pharma joined several of its peers in committing to invest billions of dollars in new and expanded manufacturing facilities in the U.S.

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Immune Therapy Works As Well In Senior Cancer Patients As In Younger Adults

Drugs.com

TUESDAY, April 22, 2025 Its well-known that a persons immune system wears down over time, becoming less effective as folks progress through middle age and become seniors.But that doesnt appear to hinder the effectiveness of immunotherapy for ca.

Therapies 242
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Adolescents who sleep longer perform better at cognitive tasks

Science Daily: Pharmacology News

Adolescents who sleep for longer -- and from an earlier bedtime -- than their peers tend to have improved brain function and perform better at cognitive tests, researchers have shown. But the study of adolescents in the US also showed that even those with better sleeping habits were not reaching the amount of sleep recommended for their age group.

Research 237
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Potentially Harmful Chemicals Found In Kids' Mattresses

Drugs.com

TUESDAY, April 22, 2025 Babies and toddlers could be exposed to harmful chemicals while they sleep, due to compounds found in their mattresses, two new studies say.Air samples taken from 25 childrens bedrooms revealed elevated levels of more tha.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Robot see, robot do: System learns after watching how-to videos

Science Daily: Pharmacology News

Researchers have developed a new robotic framework powered by artificial intelligence -- called RHyME (Retrieval for Hybrid Imitation under Mismatched Execution) -- that allows robots to learn tasks by watching a single how-to video.

Research 195
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RFK Jr.'s Major Autism Study To Use Private Health Records

Drugs.com

TUESDAY, April 22, 2025 The National Institutes of Health (NIH) will provide private health data to researchers for U.S. health chief Robert F. Kennedy Jr.'s new autism study.NIH Director Dr. Jay Bhattacharya told advisers the aim is to help r.

Research 196
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Astronomers discover a planet that's rapidly disintegrating, producing a comet-like tail

Science Daily: Pharmacology News

A planet 140 light-years from Earth is rapidly coming apart due to its close proximity to its star. The roasting planet is effectively evaporating away: It sheds an enormous amount of surface minerals as it whizzes around its star.

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Former Neumora CEO to lead Galapagos spinout

BioPharma Drive: Drug Pricing

Henry Gosebruch is now chief executive of the spinout, which has roughly $2.5 billion and plans to use dealmaking to build a research pipeline targeting cancer, viruses and the immune system.

Virus 169
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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AI tool grounded in evidence-based medicine outperformed other AI tools -- and most doctors- on USMLE exams

Science Daily: Pharmacology News

A powerful clinical artificial intelligence tool developed by biomedical informatics researchers has demonstrated remarkable accuracy on all three parts of the United States Medical Licensing Exam (Step exams), according to a new article.

Doctors 169
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School-Based Asthma Programs Keep Kids Healthy And Learning

Drugs.com

TUESDAY, April 22, 2025 -- Kids struggle with asthma as much at school as they do at home possibly even more so, since it can be tough for them to access their medicine.So why arent all schools offering them asthma therapy?A new study says that s.

Therapies 147
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Light fields with extraordinary structure: Plasmonic skyrmion bags

Science Daily: Pharmacology News

A research group has manipulated light through its interaction with a metal surface so that it exhibits entirely new properties.

Research 154
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Arkansas passes law banning PBMs from owning pharmacies

BioPharma Drive: Drug Pricing

The law in particular will affect CVS and UnitedHealth, both of which operate physical pharmacies in the state along with specialty and mail-order pharmacy businesses.

Pharmacy 141
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Insects are disappearing due to agriculture -- and many other drivers, new research reveals

Science Daily: Pharmacology News

Insects are disappearing at an alarming rate worldwide, but why? Agricultural intensification tops the list of proposed reasons, but there are many other, interconnected drivers that have an impact, according to new research.

Research 150
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Loneliness More Common Among Middle-Aged In U.S.

Drugs.com

TUESDAY, April 22, 2025 Loneliness among seniors has been a huge concern among experts on aging as social isolation increases risk of dementia, health problems, psychological disorders and deaths.But a new study suggests that, at least in the U.

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Big brains and big ranges might not save birds from climate change

Science Daily: Pharmacology News

Some species that breed over large geographic areas can still be adapted to a fairly narrow range of climates, making them more vulnerable to climate change than previously thought. Also, species with larger brains (relative to their body size) tend to be adapted to narrower climate niches, which suggests they too could also be more vulnerable than once thought.

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Prevalence of Depression Increased Over Last Decade

Drugs.com

TUESDAY, April 22, 2025 -- The prevalence of depression among adolescents and adults aged 12 years and older during August 2021 to August 2023 was 13.1 percent, a 60 percent increase from 2013-2014, according to an April data brief published by the.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Pioneering AI in Molecular Biology: Featuring nobel Laureate David Baker

keypoint

Nobel Laureate David Baker will give the closing Keynote address at the upcoming Keystone Symposia meeting: AI in Molecular Biology, taking place September 15-18, in Santa Fe, New Mexico.

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'The Talk' Is A Touchy Subject For Many Parents

Drugs.com

TUESDAY, April 22, 2025 The Talk.Its an anxiety-producing proposition for just about every parent and as you might expect, opinions vary widely about when and how to have The Talk with a child nearing puberty.Parents are evenly split in think.

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Akeso claims another PD-1/VEGF win; FDA requests more data from Novavax

BioPharma Drive: Drug Pricing

An ivonescimab-chemotherapy combination succeeded in a study in China. Elsewhere, the FDA asked Novavax for more COVID vaccine data and Regeneron boosted its manufacturing capabilities.

FDA 152
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Most Women Are Comfortable With AI-Assisted Mammography

Drugs.com

TUESDAY, April 22, 2025 -- Women are OK with having an AI program help doctors review mammograms performed for breast cancer screening, a new study says.About 7 out of 10 women (71%) said theyre fine with an AI program providing backup for a r.

Doctors 130
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The Trump administration is remaking HHS. Track the changes here.

BioPharma Drive: Drug Pricing

Health secretary Robert F. Kennedy Jr. has ordered a drastic downsizing of HHS that employees and critics say risks degrading essential services and functions.

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Federal COVID Websites Now Promote Lab Leak Theory

Drugs.com

TUESDAY, April 22, 2025 The Trump administration has replaced two major federal websites for COVID information with a new page that promotes the theory that the virus came from a lab in China.Covid.gov and Covidtests.gov, which once helped people o.

Virus 152
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Transformable flat-to-shape objects created using sewing technology

Science Daily: Pharmacology News

Researchers introduced a novel method for fabricating functional flat-to-shape objects using a computer-controlled sewing machine. The team's method uses the sewing machine to stitch pockets between layers of fabric, and stiff panels are inserted into the pockets. Multiple fabrics types can be used, ranging from muslin for heavy-duty applications to more delicate fabrics for decorative purposes.

Research 148
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Trump Administration Plans Ban on More Synthetic Food Dyes

Drugs.com

TUESDAY, April 22, 2025 The Trump administration is expected to take new steps to remove artificial food dyes from the U.S. food supply, officials say.Health and Human Services Secretary Robert F. Kennedy Jr. and FDA Commissioner Dr. Marty Makary.

FDA 154
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Sulopenem

New Drug Approvals

Sulopenem 120788-07-0 CP-70429 349.5 g/mol, C 12 H 15 NO 5 S 3 XX514BJ1XW PF-03709270 PF03709270 (5 R ,6 S )-6-[(1 R )-1-hydroxyethyl]-7-oxo-3-[(1 R ,3 S )-1-oxothiolan-3-yl]sulfanyl-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (5R,6S)-6-((1R)-1-HYDROXYETHYL)-7-OXO-3-(((1R,3S)-1-OXOTETRAHYDRO-1H-1.LAMBA.(SUP 4)-THIOPHEN-3-YL)SULFANYL)-4-THIA-1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID (5R,6S)-6-((1R)-1-Hydroxyethyl)-7-oxo-3-(((3S)-tetrahydro-3-thienyl)thio)-4-thia-1-azabicyclo(3.2.

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AI-powered imaging for faster lung disease treatment

Drug Target Review

Artificial intelligence (AI) is transforming the landscape of modern medicine, with deep learning at the forefront of this revolution. Deep learning (DL) rapidly analyses complex medical data, identifying patterns in diseases with subtle, progressive symptoms such as respiratory conditions where early detection is crucial. Among these conditions is idiopathic pulmonary fibrosis (IPF), which poses a significant health challenge due to its unpredictable course and high mortality rate.