Sat.Mar 08, 2025

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Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor

Covalent Modifiers

Beatrice Noce, Sara Marchese, Marta Massari, Chiara Lambona, Joana Reis, Francesco Fiorentino, Alessia Raucci, Rossella Fioravanti, Mariana Castela, Alessandro Mormino, Stefano Garofalo, Cristina Limatola, Lorenzo Basile, Andrea Gottinger, Claudia Binda, Andrea Mattevi, Antonello Mai, and Sergio Valente Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.4c02644 NADPH oxidases (NOXs) are enzymes dedicated to reactive oxygen species (ROS) production and are implicated in cancer, neuroin

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What Is Cardiovascular Disease?

Drugs.com

SATURDAY, March 8, 2025 -- Cardiovascular disease is a general term that refers to many different types of heart problems.Heart disease is the No. 1 cause of death in the United States. In fact, one American dies from heart disease every 33.

Disease 165
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‘Direct-to-biology’ drives optimisation of a cell-active covalent 1 inhibitor of WRN helicase

Covalent Modifiers

1S. M. Rowe, A. Price, D. J. Murphy, J. Lin, E. N. Nartey, A. Chaikuad, K. Wong, J. E. Cottom, N. O. Concha, R. A. Reid, E. R. Dickinson, M. Jundt, K. Kammerer, M. Steidel, T. Mathieson, T. Werner, E. K. Grant, C. K. Stanborough, M. Rouah, J. Wojno-Picon, P. Pogny, J. Pettinger, D. J. Norman, H. Wilders, F. Rianjongdee, G. Valdes-Garcia, N. Nevins, R.

DNA 100
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Shattering the glass ceiling: empowering women and girls in STEM

Drug Target Review

Notable imbalances exist across STEM subjects at the undergraduate level, with many female students enrolling in fields like psychology and subjects allied to medicine (eg, nursing), which often lead to lower-paid career paths. However, women remain dramatically underrepresented in core STEM fields, accounting for just 34 percent of the STEM workforce and being vastly outnumbered by men in most STEM majors.

Science 99
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Responsible Design Starts within the Institution

Perficient: Drug Development

The global business landscape is complex, and responsible design has emerged as a critical imperative for organizations across sectors. It represents a fundamental shift from viewing design merely as a creative output to recognizing it as an ethical responsibility embedded within institutional structures and processes. True transformation toward responsible design practices cannot be achieved through superficial initiatives or isolated projects.

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Championing Women at Adobe Summit 2025

Perficient: Drug Development

The month of March offers so many opportunities to celebrate the contributions women have made across different fields all over the world. As we continue to recognize women this month, were excited to bring the celebration to Adobe Summit 2025! Our Women in Digital Breakfast is returning for its ninth year and we’re also supporting the nonprofit organization Girls Who Code.