Sun.Sep 24, 2023

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How to Care for a New Body Piercing

Drugs.com

SUNDAY, Sept. 24, 2023 -- Piercings can be a fun way to express yourself, but they can also cause complications — particularly in areas that aren’t the earlobes — and need proper care. “The first step to caring for your piercing is choosing.

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Jasminoidin reduces ischemic stroke injury by regulating microglia polarization via PASK?EEF1A1 axis

Chemical Biology and Drug Design

In this study, Jasminoidin was demonstrated to block microglia M1 polarization and promote M2 polarization by targeting Per-Arnt-Sim kinase (PASK) to enhance p-eukaryotic elongation factor 1A1 (EEF1A1) phosphorylation pathway. This finding provides new ideas for the development of drug targets for the treatment of ischemic stroke. Abstract Jasminoidin (JAS) can alleviate ischemic stroke (IS) injury, but its molecular mechanism remains undefined.

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EXCLUSIVE: The 340B Program Reached $54 Billion in 2022—Up 22% vs. 2021

Drug Channels

Drug Channels has just obtained new details on the size of the 340B Drug Pricing Program. I couldn’t wait to share the news, hence this special Sunday post. For 2022, discounted purchases under the 340B program reached a record $53.7 billion —an astonishing $9.8 billion (+22.3%) higher than its 2021 counterpart. The difference between list prices and discounted 340B purchases also grew, to $52.3 billion (+$2.6 billion).

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CPSC Decision Highlights Some Don’ts of Agency Rulemaking

FDA Law Blog: Biosimilars

By Faraz Siddiqui — Every parent is familiar with the parade of horrors that accompany household items as mundane as window coverings. The cords that dangle from blinds are universally recognized as a grave danger to infants and children. It is also a hot-button issue for the U.S. Consumer Product Safety Commission (CPSC), the federal agency charged with monitoring and enforcing against dangerous consumer products.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Which pharmaceutical companies have the most SPCs in Spain?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most supplementary protection certificates (SPCs) in Spain. SPCs are used in European Union and select others to encourage pharmaceutical innovation by compensating… The post Which pharmaceutical companies have the most SPCs in Spain? appeared first on DrugPatentWatch - Make Better Decisions.

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Global study provides new insights into barriers to effective cardiovascular rehabilitation for women and why women are less likely to participate

SCIENMAG: Medicine & Health

Philadelphia, September 25, 2023 – Cardiovascular rehabilitation (CR) improves health outcomes and well-being and can reduce death and re-hospitalization rates by 20%. However, programs are underutilized and women are much less likely to participate than men, so they do not reap these benefits.

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Discovery of natural multi?targets neuraminidase inhibitor glycosides compounds against influenza A virus through network pharmacology, virtual screening, molecular dynamics simulation, and in vitro experiment

Chemical Biology and Drug Design

Eight natural multi-targets neuraminidase inhibitor glycosides compounds (IC 50  = 0.09432–93.86 μM) are discovered through network pharmacology, molecular docking, dynamics simulation, quantum chemistry, and in vitro verification. Moreover, these compounds treat influenza A virus through targets TLR4, TNF, IL6, MAPK1, MAPK3, IL1B, CASP3, AKT1, and EP300.

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