Sat.Jan 11, 2025 - Fri.Jan 17, 2025

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‘The bar has risen’: China’s biotech gains push US companies to adapt

BioPharma Drive: Drug Pricing

Pharma dealmaking for drugs invented in China is putting pressure on U.S. biotechs to compete harder, according to investors and executives interviewed by BioPharma Dive at the J.P. Morgan Healthcare Conference.

Drugs 144
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Gene editing extends lifespan in mouse model of prion disease

Broad Institute

Gene editing extends lifespan in mouse model of prion disease By Allessandra DiCorato January 14, 2025 Breadcrumb Home Gene editing extends lifespan in mouse model of prion disease A single-letter edit in DNA reduces levels of the disease-causing prion protein in the brain and could lead to a preventative, one-time treatment for the deadly neurodegenerative disorder.

Disease 144
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The megadroughts are upon us

Science Daily: Pharmacology News

Increasingly common since 1980, persistent multi-year droughts will continue to advance with the warming climate, warns a new study. This publicly available forty-year global quantitative inventory seeks to inform policy regarding the environmental impact of human-induced climate change. It also detected previously 'overlooked' events.

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Evaluating GenMol as a Generalist Foundation Model for Molecular Generation

Nvidia Developer: Drug Discovery

Traditional computational drug discovery relies almost exclusively on highly task-specific computational models for hit identification and lead optimization. Traditional computational drug discovery relies almost exclusively on highly task-specific computational models for hit identification and lead optimization. Adapting these specialized models to new tasks requires substantial time, computational power, and expertisechallenges that grow when researchers simultaneously work across multiple ta

Drugs 132
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Roche’s new deals head tries to navigate a more ‘complicated’ and ‘expensive’ biotech world

BioPharma Drive: Drug Pricing

Roche's core research spans five large areas. Boris Zaïtra, who now leads corporate business development, is confident his team of dealmakers can juggle them.

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Critical ocean current has not declined in the last 60 years

Science Daily: Pharmacology News

The Atlantic Meridional Overturning Circulation (AMOC) has not slowed down since the mid-20th century based on the North Atlantic air-sea heat fluxes over that time. This finding contrasts with studies that have estimated a decline in the AMOC, likely because previous studies rely on sea surface temperature measurements to understand how the AMOC has changed.

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Leveraging AI Solutions for Clinical Trial Efficiencies

PPD

As clinical trials become increasingly complex, particularly in decentralized trials and rare disease studies, sponsors experience increased challenges in site selection, forecasting and resourcing, and patient recruitment and enrollment. Advanced artificial intelligence (AI) and machine learning solutions are revolutionizing critical challenge areas.

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JPM25: The FDA’s future, AbbVie’s second thoughts and Lilly’s lesson

BioPharma Drive: Drug Pricing

AbbVie's CEO hinted his company may be less willing to invest in psychiatry after a costly setback, while Lilly explained what it got wrong forecasting GLP-1 drug demand.

Drugs 125
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What Do Sleep Medications Do to Your Brain?

Drugs.com

MONDAY, Jan. 13, 2025 (HealthDay news) -- The sleep aid Ambien could be allowing toxic proteins to pollute the brain, potentially increasing a persons risk of disorders like Alzheimers disease.Drugs like the main ingredient in Ambien, zolpidem, sup.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Engineering quantum entanglement at the nanoscale

Science Daily: Pharmacology News

Researchers have developed a drastically smaller and more energy efficient method of creating coveted photon pairs that influence each other from any distance. The technology could transform computing, telecommunications, and sensing.

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Scientific workflow for hypothesis testing in drug discovery: Part 2 of 3

Drug Target Review

Drug discovery scientists spend their days developing and testing complex hypotheses, leveraging data and expertise through workflows that utilise available tools. Operating a workflow, such as the one described in Figure 1, involves several key considerations that affect both the accuracy of results and the efficiency of the research process. Defining the research question A well-defined research question is the cornerstone of an effective scientific workflow in drug discovery.

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Moderna shares tumble on slashed sales guidance

BioPharma Drive: Drug Pricing

The company lost more than $3 billion in market value after cutting its forecast for 2025 revenue from its COVID-19 and RSV vaccines.

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Zolendrate (Reclast) Lowers Fracture Risk in Early Postmenopausal Women

Drugs.com

FRIDAY, Jan. 17, 2025 -- Women past menopause can protect themselves from future fractures through infrequent, cheap IV infusions of a bone-strengthening drug. Women 50 to 60 who got two IV infusions of zoledronate (Reclast) within five years had a.

Drugs 111
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Deep learning designs proteins against deadly snake venom

Science Daily: Pharmacology News

New proteins not found in nature have now been designed to counteract certain highly poisonous components of snake venom. The deep learning, computational methods for developing these toxin-neutralizing proteins offer hope for creating safer, more cost-effective and more readily available therapeutics than those currently in use. Each year more than 2 million people suffer snakebites.

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Why Google Patents Is Not a Good Solution to Identify Drug Patents

Drug Patent Watch

Identifying drug patents is crucial for various stakeholders, including researchers, legal professionals, and business strategists. While Google Patents is a widely used tool for searching patent information, it may not be the most effective solution for identifying drug patents. This article explores the limitations of Google Patents in this context and suggests alternative approaches.

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5 questions facing emerging biotech in 2025

BioPharma Drive: Drug Pricing

Young drugmakers confront several harsh realities this year, among them a contracting sector and competition from China.

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Bird Flu Kills 20 Million Chickens in U.S., Driving Egg Prices Sky-High

Drugs.com

TUESDAY, Jan. 14, 2025 -- A deadly bird flu outbreak has wreaked havoc on U.S. chicken farms, claiming the lives of over 20 million egg-laying chickens last quarter, marking the worst impact on America's egg supply since the outbreak began in.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Astrophysicists reveal structure of 74 exocomet belts orbiting nearby stars in landmark survey

Science Daily: Pharmacology News

Astrophysicists have imaged a large number of exocomet belts around nearby stars, and the tiny pebbles within them. The crystal-clear images show light being emitted from these millimeter-sized pebbles within the belts that orbit 74 nearby stars of a wide variety of ages -- from those that are just emerging from birth to those in more mature systems like our own Solar System.

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Accelerate Protein Engineering with the NVIDIA BioNeMo Blueprint for Generative Protein Binder Design

Nvidia Developer: Drug Discovery

Designing a therapeutic protein that specifically binds its target in drug discovery is a staggering challenge. Traditional workflows are often a painstaking. Designing a therapeutic protein that specifically binds its target in drug discovery is a staggering challenge. Traditional workflows are often a painstaking trial-and-error processiterating through thousands of candidates, each synthesis and validation round taking months if not years.

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Lilly blames slower-than-expected growth for 2024 sales miss

BioPharma Drive: Drug Pricing

The company said it overestimated demand of its obesity and diabetes drugs in the fourth quarter, but projected a further ramp-up in sales this year.

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Updated Guidelines for Preventing Osteoporosis-Related Fractures Released

Drugs.com

TUESDAY, Jan. 14, 2025 -- All women 65 and older should continue to be screened for osteoporosis, the nation’s leading preventive health panel says in an updated recommendation. The U.S. Preventive Services Task Force also recommends.

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United States dementia cases estimated to double by 2060

Science Daily: Pharmacology News

A new study shows that the risk of developing dementia anytime after age 55 among Americans is 42%, more than double the risk reported by older studies.

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Early Commercial Planning: Mitigate Patient Access Challenges for Cell and Gene Therapies

Fierce BioTech

Early Commercial Planning: Mitigate Patient Access Challenges for Cell and Gene Therapies swheeler Thu, 01/16/2025 - 17:26 Thu, 03/06/2025 - 11:00 Resource Type Webinar Fran Gregory, PharmD, MBA Josh Marsh Kathryne Kirk Kelly Kester Duration 60 minutes Cell and gene therapies (CGTs) offer fresh hope to patients with serious and debilitating diseases, often where no other treatment options are available.

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Medicare will negotiate Novo’s GLP-1 drug price. Here’s what that means for Ozempic, Wegovy.

BioPharma Drive: Drug Pricing

Novo sells semaglutide as Ozempic and Rybelsus for diabetes and as Wegovy for obesity. In price talks, CMS will treat the different forms as a single product.

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CDC Confirms Another Human Bird Flu Case, Bringing Total to 67

Drugs.com

FRIDAY, Jan. 17, 2025 -- The U.S. Centers for Disease Control and Prevention (CDC) confirmed another human H5N1 avian flu case -- otherwise known as bird flu -- in California on Thursday, bringing the nationwide total of cases to 67.California has.

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Is eating more red meat bad for your brain?

Science Daily: Pharmacology News

People who eat more red meat, especially processed red meat like bacon, sausage and bologna, are more likely to have a higher risk of cognitive decline and dementia when compared to those who eat very little red meat, according to a new study.

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Glycoproteomic biomarkers in the clinic: How InterVenn is powering the development of predictive biomarkers for therapeutic response.

Fierce BioTech

Glycoproteomic biomarkers in the clinic: How InterVenn is powering the development of predictive biomarkers for therapeutic response. pesurya Thu, 01/16/2025 - 14:23 Thu, 02/27/2025 - 14:00 Resource Type Webinar Dr. David Braun Dan Serie, M.S. Alex Vanotti, MBA Duration 60 Minutes The search for biomarkers for therapeutic response using traditional genomic sequencing and other omic approaches has not yielded clinically actionable tools for most patients.

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J&J to buy psychiatric drug developer Intra-Cellular for $14.6B

BioPharma Drive: Drug Pricing

Intra-Cellular has had success selling Caplyta, a brain-rebalancing drug that's approved to treat schizophrenia and bipolar depression.

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These Lifestyle Moves Help Ease Low Back Pain, Study Shows

Drugs.com

FRIDAY, Jan. 17, 2025 -- Suffering from low back pain?Addressing your unhealthy lifestyle habits could help ease your pain better than traditional care, a new study says.Back pain sufferers who got lifestyle coaching functioned better and had.

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This metaphorical cat is both dead and alive -- and it will help quantum engineers detect computing errors

Science Daily: Pharmacology News

Engineers have demonstrated a well-known quantum thought experiment in the real world. Their findings deliver a new and more robust way to perform quantum computations and they have important implications for error correction, one of the biggest obstacles standing between them and a working quantum computer.