Sat.Jan 11, 2025 - Fri.Jan 17, 2025

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‘The bar has risen’: China’s biotech gains push US companies to adapt

BioPharma Drive: Drug Pricing

Pharma dealmaking for drugs invented in China is putting pressure on U.S. biotechs to compete harder, according to investors and executives interviewed by BioPharma Dive at the J.P. Morgan Healthcare Conference.

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Scientific workflow for hypothesis testing in drug discovery: Part 2 of 3

Drug Target Review

Drug discovery scientists spend their days developing and testing complex hypotheses, leveraging data and expertise through workflows that utilise available tools. Operating a workflow, such as the one described in Figure 1, involves several key considerations that affect both the accuracy of results and the efficiency of the research process. Defining the research question A well-defined research question is the cornerstone of an effective scientific workflow in drug discovery.

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Why Google Patents Is Not a Good Solution to Identify Drug Patents

Drug Patent Watch

Identifying drug patents is crucial for various stakeholders, including researchers, legal professionals, and business strategists. While Google Patents is a widely used tool for searching patent information, it may not be the most effective solution for identifying drug patents. This article explores the limitations of Google Patents in this context and suggests alternative approaches.

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Gene editing extends lifespan in mouse model of prion disease

Broad Institute

Gene editing extends lifespan in mouse model of prion disease By Allessandra DiCorato January 14, 2025 Breadcrumb Home Gene editing extends lifespan in mouse model of prion disease A single-letter edit in DNA reduces levels of the disease-causing prion protein in the brain and could lead to a preventative, one-time treatment for the deadly neurodegenerative disorder.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Deep learning designs proteins against deadly snake venom

Science Daily: Pharmacology News

New proteins not found in nature have now been designed to counteract certain highly poisonous components of snake venom. The deep learning, computational methods for developing these toxin-neutralizing proteins offer hope for creating safer, more cost-effective and more readily available therapeutics than those currently in use. Each year more than 2 million people suffer snakebites.

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Evaluating GenMol as a Generalist Foundation Model for Molecular Generation

Nvidia Developer: Drug Discovery

Traditional computational drug discovery relies almost exclusively on highly task-specific computational models for hit identification and lead optimization. Traditional computational drug discovery relies almost exclusively on highly task-specific computational models for hit identification and lead optimization. Adapting these specialized models to new tasks requires substantial time, computational power, and expertisechallenges that grow when researchers simultaneously work across multiple ta

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Broad Institute and Manifold collaborate to build AI-enabled life sciences research platform to accelerate global discoveries

Broad Institute

Broad Institute and Manifold collaborate to build AI-enabled life sciences research platform to accelerate global discoveries By Corie Lok January 13, 2025 Breadcrumb Home Broad Institute and Manifold collaborate to build AI-enabled life sciences research platform to accelerate global discoveries Strategic collaboration will introduce AI-enabled tools, optimized data-sharing, bring your own cloud (BYOC) support, and enhanced scalability.

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DNA nanorobots can alter artificial cells

Science Daily: Pharmacology News

Scientists have succeeded in controlling the structure and function of biological membranes with the help of 'DNA origami'. The system they developed may facilitate the transportation of large therapeutic loads into cells. This opens up a new way for the targeted administration of medication and other therapeutic interventions. Thus, a very valuable instrument can be added to the toolbox of synthetic biology.

DNA
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The Role of the FDA’s Oncology Center of Excellence in Advancing Cancer Care

The Premier Consulting Blog

The FDAs Oncology Center of Excellence (OCE) plays a pivotal role in fostering innovation, collaboration, and efficiency in the development and evaluation of oncology products. Established in 2017 under the 21st Century Cures Act, the OCE brings together multidisciplinary scientific expertise to accelerate the review and approval of drugs, biologics, and medical devices for cancer care.

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Pharmaceutical Negotiations Decoded: Lessons from the Trenches

Drug Patent Watch

In the fast-paced world of pharmaceuticals, negotiations play a pivotal role in shaping the industry’s landscape. From mergers and acquisitions to licensing agreements and pricing discussions, these complex interactions demand a unique blend of scientific knowledge, business acumen, and interpersonal skills. Let’s dive into the intricacies of pharmaceutical negotiations, exploring valuable lessons, current trends, and strategies for success.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Mastering Database.SaveResult in Batch Class: A Beginner-Friendly Guide

Perficient: Drug Development

Imagine youre a skilled craftsman working in a massive warehouse. Every day, your task is to process thousands of unique items and ensure that each one is properly logged and stored. But lets face it mistakes happen. Sometimes an item gets mislabeled or damaged, and you need to know which ones to fix, and which ones made it safely through. In Salesforce, when working with a batch class that processes thousands or even millions of records, Database.SaveResult acts as your trusty supervisor, keep

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Accelerate Protein Engineering with the NVIDIA BioNeMo Blueprint for Generative Protein Binder Design

Nvidia Developer: Drug Discovery

Designing a therapeutic protein that specifically binds its target in drug discovery is a staggering challenge. Traditional workflows are often a painstaking. Designing a therapeutic protein that specifically binds its target in drug discovery is a staggering challenge. Traditional workflows are often a painstaking trial-and-error processiterating through thousands of candidates, each synthesis and validation round taking months if not years.

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Why 340B Reform Could Happen in 2025 (video)

Drug Channels

During my recent Drug Channels Outlook 2025 video webinar, I tackled a wide range of crucial topicsincluding the controversial 340B Drug Pricing Program. As I explain in this video excerpt, we may finally see reform of this rapidly expanding program. Whats more, implementing the Inflation Reduction Act will disrupt the current operations of the 340B programand could shift program oversight from Health Resources and Services Administration to the Centers for Medicare & Medicaid Services.

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Analyzing biosimilar market dynamics in different patient populations

Drug Patent Watch

Biosimilars have emerged as a game-changing force, promising to revolutionize patient access to life-saving biologics while simultaneously reducing healthcare costs. As we delve into the intricate world of biosimilar market dynamics, we’ll explore how these complex molecules are reshaping treatment paradigms across diverse patient populations.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Kristen Quick Explains the Impact of Salesforce Life Sciences Cloud

Perficient: Drug Development

Kristen Quick, Director at Perficient, shared her insights on the transformative potential of Salesforce Life Sciences Cloud for pharmaceutical and med tech organizations, highlighting its ability to drive innovation and improve outcomes. As the healthcare landscape continues to evolve, innovative solutions like Life Sciences Cloud are becoming essential for driving efficiency, improving patient care, and accelerating time to market: Introduction to Kristen Quick Kristen Quick is a director i

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FDA’s Issues Draft Guidance on Accelerated Approval: A Substantial Evidentiary and Procedural Overhaul to this High-Profile Pathway

FDA Law Blog: Drug Discovery

By Charles G. Raver & James E. Valentine & Ellis Unger & Frank J. Sasinowski On December 5, 2024, FDA published a new draft guidance on accelerated approval providing a much needed and substantial update to its guidance on the pathway. FDAs application and use of accelerated approval has evolved dramatically since it was first developed by the Agency to help address the HIV/AIDS epidemic in the late 1980s.

FDA
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Drug Channels Leadership Forum: Request an Invitation Before It’s Too Late!

Drug Channels

The inaugural Drug Channels Leadership Forum (DCLF) is coming soon! This exclusive event will be held from March 17 to 19, 2025, at the Turnberry Resort and Spa in Miami. Our first event will provide attendees with an opportunity to explore the most pressing strategic issues and crucial uncertainties that will impact all participants across U.S. drug channels.

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Innovative Approaches to Generic Drug Development: Case Studies

Drug Patent Watch

The Generic Drug Revolution: Setting the Stage Before we dive into the nitty-gritty, let’s take a moment to appreciate the impact of generic drugs. Did you know that generic drugs now make up about 90% of all prescription drug purchases in the United States, while accounting for only 20% of prescription drug spending[1]? That’s right, these unsung heroes are saving our healthcare system trillions of dollars!

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Key Insights from the Front-End Meetup by the Front-End Meetup Group

Perficient: Drug Development

Let me take you through the event that perfectly wrapped up 2024! Perficient’s Front-End Team concluded the year with a memorable meetup filled with inspiring sessions and networking, setting the stage for an exciting 2025. We’re already excited about the next one! Event Overview The Front-End Meetup, hosted by the Front-end Meetup Group and sponsored by Perficient, began at 10:00 AM with great energy as developers, designers, and tech enthusiasts gathered.

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The megadroughts are upon us

Science Daily: Pharmacology News

Increasingly common since 1980, persistent multi-year droughts will continue to advance with the warming climate, warns a new study. This publicly available forty-year global quantitative inventory seeks to inform policy regarding the environmental impact of human-induced climate change. It also detected previously 'overlooked' events.

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JPM25: The FDA’s future, AbbVie’s second thoughts and Lilly’s lesson

BioPharma Drive: Drug Pricing

AbbVie's CEO hinted his company may be less willing to invest in psychiatry after a costly setback, while Lilly explained what it got wrong forecasting GLP-1 drug demand.

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What Do Sleep Medications Do to Your Brain?

Drugs.com

MONDAY, Jan. 13, 2025 (HealthDay news) -- The sleep aid Ambien could be allowing toxic proteins to pollute the brain, potentially increasing a persons risk of disorders like Alzheimers disease.Drugs like the main ingredient in Ambien, zolpidem, sup.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Early Commercial Planning: Mitigate Patient Access Challenges for Cell and Gene Therapies

Fierce BioTech

Early Commercial Planning: Mitigate Patient Access Challenges for Cell and Gene Therapies swheeler Thu, 01/16/2025 - 17:26 Thu, 03/06/2025 - 11:00 Resource Type Webinar Fran Gregory, PharmD, MBA Josh Marsh Kathryne Kirk Kelly Kester Duration 60 minutes Cell and gene therapies (CGTs) offer fresh hope to patients with serious and debilitating diseases, often where no other treatment options are available.

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Critical ocean current has not declined in the last 60 years

Science Daily: Pharmacology News

The Atlantic Meridional Overturning Circulation (AMOC) has not slowed down since the mid-20th century based on the North Atlantic air-sea heat fluxes over that time. This finding contrasts with studies that have estimated a decline in the AMOC, likely because previous studies rely on sea surface temperature measurements to understand how the AMOC has changed.

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Roche’s new deals head tries to navigate a more ‘complicated’ and ‘expensive’ biotech world

BioPharma Drive: Drug Pricing

Roche's core research spans five large areas. Boris Zaïtra, who now leads corporate business development, is confident his team of dealmakers can juggle them.

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Zolendrate (Reclast) Lowers Fracture Risk in Early Postmenopausal Women

Drugs.com

FRIDAY, Jan. 17, 2025 -- Women past menopause can protect themselves from future fractures through infrequent, cheap IV infusions of a bone-strengthening drug. Women 50 to 60 who got two IV infusions of zoledronate (Reclast) within five years had a.

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Glycoproteomic biomarkers in the clinic: How InterVenn is powering the development of predictive biomarkers for therapeutic response.

Fierce BioTech

Glycoproteomic biomarkers in the clinic: How InterVenn is powering the development of predictive biomarkers for therapeutic response. pesurya Thu, 01/16/2025 - 14:23 Thu, 02/27/2025 - 14:00 Resource Type Webinar Dr. David Braun Dan Serie, M.S. Alex Vanotti, MBA Duration 60 Minutes The search for biomarkers for therapeutic response using traditional genomic sequencing and other omic approaches has not yielded clinically actionable tools for most patients.

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Engineering quantum entanglement at the nanoscale

Science Daily: Pharmacology News

Researchers have developed a drastically smaller and more energy efficient method of creating coveted photon pairs that influence each other from any distance. The technology could transform computing, telecommunications, and sensing.

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5 questions facing emerging biotech in 2025

BioPharma Drive: Drug Pricing

Young drugmakers confront several harsh realities this year, among them a contracting sector and competition from China.

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FDA Will No Longer Allow Use of Red Dye No. 3 in Food, Drugs

Drugs.com

WEDNESDAY, Jan. 15, 2025 -- The U.S Food and Drug Administration has amended its color additive regulations to no longer allow the use of Federal Food, Drug, and Cosmetic Act (FD&C Act) Red No. 3 in food and ingested drugs.FD&C Red No. 3 is.

FDA
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Single-cell Multiome Technology and Analysis Methods

Broad Institute

Single-cell Multiome Technology and Analysis Methods By Rose Circeo January 16, 2025 Breadcrumb Home Single-cell Multiome Technology and Analysis Methods The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Experts from across the Medical and Population Genetics community at the Broad Institute give in-depth introductions to research in human genetics through overviews of core concepts and practical tutorials on

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Astrophysicists reveal structure of 74 exocomet belts orbiting nearby stars in landmark survey

Science Daily: Pharmacology News

Astrophysicists have imaged a large number of exocomet belts around nearby stars, and the tiny pebbles within them. The crystal-clear images show light being emitted from these millimeter-sized pebbles within the belts that orbit 74 nearby stars of a wide variety of ages -- from those that are just emerging from birth to those in more mature systems like our own Solar System.