Sat.Aug 31, 2024 - Fri.Sep 06, 2024

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Travel could be the best defense against aging

Science Daily: Pharmacology News

Forget about retinol night creams, researchers believe travel could be the best way to defy premature aging. An interdisciplinary study has applied the theory of entropy to tourism, finding that travel could have positive health benefits, including slowing down the signs of aging.

Research 351
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A decade of cancer immunotherapy: Keytruda, Opdivo and the drugs that changed oncology

BioPharma Drive: Drug Pricing

Over the past 10 years, PD1-blocking medicines have transformed cancer care. But the steady expansion of their use has slowed and, despite much trying, pharmaceutical companies have largely failed to top the drugs’ successes.

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Almost 1 in 4 U.S. Adults Under 40 Have High Blood Pressure

Drugs.com

FRIDAY, Sept. 6, 2024 -- An epidemic of high blood pressure is occurring in young adults and children in the United States, a pair of new studies show.Nearly a quarter of people ages 18 to 39 have high blood pressure, with readings above the.

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Sept 2024 - Q3 Product Update Webinar: Curves, AI, Inventory, and ELN

Collaborative Drug

We recently hosted our Sept 2024 Q3 Product Update Webinar, showcasing significant enhancements to the CDD Vault platform. The webinar covered four key modules: Curves, AI, Inventory Management, and Electronic Lab Notebook (ELN). Let's dive into the exciting updates for each module.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Fungus-controlled robots tap into the unique power of nature

Science Daily: Pharmacology News

In creating a pair of new robots, researchers cultivated an unlikely component, one found on the forest floor: fungal mycelia. By harnessing mycelia's innate electrical signals, the researchers discovered a new way of controlling 'biohybrid' robots that can potentially react to their environment better than their purely synthetic counterparts.

Research 350

More Trending

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Ozempic, Wegovy Won't Raise User's Suicide Risk, Study Finds

Drugs.com

TUESDAY, Sept. 3, 2024 -- The booming popularity of the weight-loss drug semaglutide has prompted increasing concerns about potential side effects from taking Ozempic or Wegovy.But a new study rules out one possible problem -- using semaglutide.

Drugs 299
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From Mechanism-Based Retaining Glycosidase Inhibitors to Activity-Based Glycosidase Profiling

Covalent Modifiers

Marta Artola, Johannes M. F. G. Aerts, Gijsbert A. van der Marel, Carme Rovira, Jeroen D. C. Codée, Gideon J. Davies, and Herman S. Overkleeft Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.4c08840 Activity-based protein profiling (ABPP) is an effective technology for the identification and functional annotation of enzymes in complex biological samples.

Disease 133
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Researchers give adult zebra finches back their ability to learn new songs

Science Daily: Pharmacology News

We all know the adage, 'You can't teach an old dog new tricks.' As we age, our ability to learn new skills, like mastering a foreign language or picking up a musical instrument, seems to fade. The culprit? A decline in brain plasticity - the brain's capacity to rewire itself and adapt to new challenges. But what if we could rewind the clock on this age-related decline?

Research 349
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New research could ease concerns over suicide risk of obesity drugs

BioPharma Drive: Drug Pricing

While results from two after-the-fact analyses were “reassuring,” outside experts urged “continued vigilance” to ensure GLP-1 drugs don’t worsen problems in people with preexisting mental health conditions.

Research 307
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Saltwater Drops in Nose Could Shorten Kids' Colds

Drugs.com

FRIDAY, Sept. 6, 2024 -- Saltwater nose drops can reduce the length of a kid’s cold by two days, a new study demonstrates.“We found that children using saltwater nose drops had cold symptoms for an average of six days, where those with usual care ha.

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SuFEx Chemistry Enables Covalent Assembly of a 280-kDa 18-Subunit Pore-Forming Complex

Covalent Modifiers

Lee Schnaider, Sophia Tan, Pratik R. Singh, Floriana Capuano, Alistair J. Scott, Richard Hambley, Lei Lu, Hyunjun Yang, E. Jayne Wallace, Hyunil Jo, and William F. DeGrado Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.4c07920 Proximity-enhanced chemical cross-linking is an invaluable tool for probing protein–protein interactions and enhancing the potency of potential peptide and protein drugs.

DNA 124
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The risk of global water scarcity is greater when accounting for the origin of rain

Science Daily: Pharmacology News

Securing the world's water supply is one of the greatest challenges of our time. Researchers are now presenting an alternative method for quantifying the global risk of water scarcity. Results indicate higher risks to water supply than previously expected if accounting for the environmental conditions and governability where rain is produced.

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Lilly builds case for weekly insulin shot

BioPharma Drive: Drug Pricing

New data show Lilly’s longer-lasting insulin matched daily shots in controlling blood sugar, adding to positive findings the company disclosed in May.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Everything You Need to Know About Insulin

Drugs.com

SATURDAY, Aug. 31, 2024 -- Insulin can be a critical part of managing diabetes, but patients may not know all of the ins and outs of using the medication effectively.Luckily, the American Diabetes Association (ADA) has plenty of information and.

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Register now for Lab Innovations 2024

Drug Discovery Today

Secure your ticket to visit the biggest lab industry trade show in the UK.

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Novel immunotherapy improves recovery from spinal cord injury

Science Daily: Pharmacology News

Researchers have designed, in mice, an approach to minimizing the damage from a spinal cord injury through the use of engineered immune cells. Mice given the treatment had improved recovery from injuries, demonstrating potential for developing the therapy for people.

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GSK antibody drug reduces COPD attacks in trial

BioPharma Drive: Drug Pricing

New trial results could offer support for an expansion of Nucala’s label after U.S. regulators rejected GSK’s submission in 2018.

Trials 259
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Brain's Wiring May Trigger Depression in Some People

Drugs.com

FRIDAY, Sept. 6, 2024 -- A distinct brain pattern appears to make some people more likely to develop depression, a new study indicates.“Deep” functional MRI brain scans revealed that a brain feature called the salience network is nearly twice as lar.

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Production Deployment and its Basics: Known to Many, Followed by Few

Perficient: Drug Development

Did you ever feel tense while taking your exams? Or you must have watched the Olympics or other sports events like cricket, football, etc. When you focus on national players during significant events, you can observe stress and anxiety in performing at that level. Similar is the situation of an IT professional during a production deployment call. This moment is crucial because it represents the end of months or years of effort, the results of which will be evaluated by those involved.

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'Forever chemicals' influence the development and function of the brain

Science Daily: Pharmacology News

Some per- and polyfluoroalkyl substances (PFAS) are poorly degradable and are also known as 'forever chemicals'. They adversely affect health and can lead to liver damage, obesity, hormonal disorders, and cancer. A research team has investigated the effects of PFAS on the brain. Using a combination of modern molecular biology methods and the zebrafish model, the researchers revealed the mechanism of action and identified the genes involved.

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Sanofi finds a silver lining in mixed MS drug results

BioPharma Drive: Drug Pricing

Tolebrutinib, which Sanofi acquired in a $3.7 billion deal, failed two studies in people with relapsing disease, but succeeded in a type of multiple sclerosis that has no approved therapies.

Therapies 176
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Ketamine Can Fight Depression, But Pregnant Women Face Risks

Drugs.com

THURSDAY, Sept. 5, 2024 -- Ketamine is becoming a popular depression drug, but doctors aren’t keeping in mind the danger it can pose to a pregnancy, a new study warns.Ketamine can be very harmful to a developing fetus and should not be used during p.

Doctors 279
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How to Scale Your Business with a CDMO

Drug Patent Watch

Scaling your business with a Contract Development and Manufacturing Organization (CDMO) is crucial for biopharmaceutical companies seeking to expedite the transition from preclinical development to clinical manufacturing. CDMOs play a vital role in providing expertise in process development and scale-up manufacturing, allowing biotech companies to adapt to changing market dynamics and client needs.

Marketing 104
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Open wide: Human mouth bacteria reproduce through rare form of cell division

Science Daily: Pharmacology News

New research has uncovered an extraordinary mechanism of cell division in Corynebacterium matruchotii, one of the most common bacteria living in dental plaque. The filamentous bacterium doesn't just divide, it splits into multiple cells at once, a rare process called multiple fission.

Research 337
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Lykos CEO to depart after FDA rejection, layoffs

BioPharma Drive: Drug Pricing

The departure of Amy Emerson as CEO comes three weeks after the MDMA developer revealed plans to cut 75% of its staff.

FDA 167
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3-in-1 Blood Pressure Pill Could Be Treatment Advance

Drugs.com

WEDNESDAY, Sept. 4, 2024 -- An experimental three-in-one blood pressure pill works better than layering on meds one at a time, a new clinical trial shows.After a month on the combo pill, 81% of patients had their blood pressure under control.

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The Role of Green Chemistry in Generic Drug Development: A Sustainable Approach to Medicine

Drug Patent Watch

The pharmaceutical industry is a significant contributor to global carbon emissions, with a projected increase of over 300% by 2050 if left unchecked. This alarming trend has led to a growing need for sustainable practices in the industry, particularly in the development of generic drugs.

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100x improvement in sight seen after gene therapy trial

Science Daily: Pharmacology News

The vision of people with a rare inherited condition that causes them to lose much of their sight early in childhood was 100 times better after they received gene therapy to address the genetic mutation causing it. Some patients even experienced a 10,000-fold improvement in their vision after receiving the highest dose of the therapy, according to researchers.

Therapies 330
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AI specialist Recursion says lead drug is safe, but efficacy less clear

BioPharma Drive: Drug Pricing

The Phase 2 results for Recursion’s cerebral cavernous malformation treatment are the first in a series of important trial readouts for the high-profile “techbio” company.

Trials 167