Sat.May 11, 2024 - Fri.May 17, 2024

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Diabetic eye disease: The urgent need for early, non-invasive treatments

Drug Discovery World

Dr Catherine Beech , CEO at Exonate and Dr Pete Adamson , CSO at Breye Therapeutics discuss the need for better therapies to treat diabetic retinal disease and current progress in the field. Diabetic retinal disease, termed diabetic retinopathy (DR), is a significant risk factor for people with Type I or II diabetes, and one that increases with time as patients experience repeated and continued issues with glycaemic control.

Disease 162
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Investors put $400M into biotech licensing obesity drugs from China

BioPharma Drive: Drug Pricing

The biotech, tentatively named Hercules CM Newco, has rights to three incretin drugs discovered by Jiangsu Hengrui Pharmaceuticals, two of which are in clinical testing.

Licensing 142
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A simple quantum internet with significant possibilities

Science Daily: Pharmacology News

It's one thing to dream up a quantum internet that could send hacker-proof information around the world via photons superimposed in different quantum states. It's quite another to physically show it's possible. That's exactly what physicists have done, using existing Boston-area telecommunication fiber, in a demonstration of the world's longest fiber distance between two quantum memory nodes to date.

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Plant-Based Diets Lower Risk of Heart Trouble, Cancer and Death

Drugs.com

THURSDAY, May 16, 2024 -- Following a vegetarian or vegan diet might just buy you a longer, healthier life, a new review finds.Staying away from meat was tied to a reduced risk of heart disease, cancer and early death, researchers reported in a.

Disease 130
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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From data to cure: The journey of AI in cancer trials

Drug Discovery World

Deepika Khedekar , Associate Centralized Clinical Trial Lead at IQVIA Inc, looks at the challenges of utilising artificial intelligence (AI) in oncology clinical research. Ten million 1 people around the world die from cancer each year. Yet, while the number of cancer clinical trials has soared from 19,211 in 2013 to a whopping 26,396 in 2022 3 , and they keep surging in 2024, the success stories are few and far between.

Trials 147
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Ajax, aiming for a better JAK drug, raises $95M to begin first tests

BioPharma Drive: Drug Pricing

Goldman Sachs and Eli Lilly are among those backing the startup, which claims its prospect could be more potent than the myelofibrosis therapies that have come to market in recent years.

Therapies 131

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Evaluation of a panel of furochromenones as the activator and inhibitor of tyrosinase

Chemical Biology and Drug Design

The study screened and identified furochromenones that impact tyrosinase activity. One of the furochromenones ( 3k ) inhibited while another ( 4f ) stimulated tyrosinase. Abstract Tyrosinase is a copper-containing enzyme involved in the biosynthesis of melanin pigment. While the excess production of melanin causes hyperpigmentation of human skin, hypopigmentation results in medical conditions like vitiligo.

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Manchester to get £60m development to enhance lab space

Drug Discovery World

Work has started on a £60 ($75.1) million development in Manchester intended to enhance the city’s Oxford Road Corridor knowledge quarter as a hub for life sciences and technology innovation. Greenheys at Manchester Science Park is scheduled for completion in Summer 2026 and will span 131,000 sq ft across six floors. The development will include specialised laboratory spaces tailored for diagnostics, genomics, biotech and precision medicine businesses.

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Biogen, Ionis shelve ALS drug following study failure

BioPharma Drive: Drug Pricing

While results indicated the drug works as intended, it didn’t have enough of an effect on a protein that’s become integral to many ALS research programs.

Drugs 127
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Global life expectancy to increase by nearly 5 years by 2050 despite geopolitical, metabolic, and environmental threats

Science Daily: Pharmacology News

The latest findings forecast that global life expectancy will increase by 4.9 years in males and 4.2 years in females between 2022 and 2050. Increases are expected to be largest in countries where life expectancy is lower, contributing to a convergence of increased life expectancy across geographies. The trend is largely driven by public health measures that have prevented and improved survival rates from cardiovascular diseases, COVID-19, and a range of communicable, maternal, neonatal, and nut

Disease 115
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Early Hints at a Gene Therapy Cure for Herpes

Drugs.com

WEDNESDAY, May 15, 2024 -- An experimental gene therapy could one day provide a first-ever cure for genital and oral herpes, researchers report.The gene therapy removed 90% or more of oral herpes infection in lab mice, and it also suppressed how.

Therapies 119
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Industry philanthropists join forces to accelerate global health and equity impact

Drug Discovery World

The Novo Nordisk Foundation, Wellcome, and the Bill & Melinda Gates Foundation have announced a new partnership to support critical scientific research and development (R&D) for global health. The partnership is focused on supporting science and innovation to advance solutions that are accessible and affordable to people in low- and middle-income countries (LMICs).

Science 147
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Lilly’s once-weekly insulin matches daily shots in late-stage tests

BioPharma Drive: Drug Pricing

The results, which showed Lilly’s drug was as effective at controlling blood sugar as standard injections, come as Novo Nordisk seeks approval for a competing once-weekly insulin.

Drugs 120
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Today's world: Fastest rate of carbon dioxide rise over the last 50,000 years

Science Daily: Pharmacology News

Today's rate of atmospheric carbon dioxide increase is 10 times faster than at any other point in the past 50,000 years, researchers have found through a detailed chemical analysis of ancient Antarctic ice.

Research 120
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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FDA Approves First Self-Test Collection Kit for HPV

Drugs.com

WEDNESDAY, May 15, 2024 -- The U.S. Food and Drug Administration has approved a kit that will allow women to collect their own vaginal sample for HPV screening, a move that could increase early detection in those at risk for cervical cancer. Women.

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Weight loss drug could be a gamechanger for cardiovascular disease

Drug Discovery World

Semaglutide (the active ingredient in Wegovy and Ozempic) can produce clinically meaningful weight loss and delivers significant cardiovascular benefits, according to two studies presented at the European Congress on Obesity (ECO). The studies are based on the Semaglutide and Cardiovascular Outcomes (SELECT) trial, the largest and longest clinical trial of the effects of semaglutide on weight in over 17,000 adults.

Disease 147
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Eisai sets new revenue target for Alzheimer’s drug Leqembi

BioPharma Drive: Drug Pricing

The annual forecast, which comes as Eisai and Biogen have begun submitting a more convenient form of Leqembi for approval, looks “more realistic” than previous guidance, according to Jefferies analysts.

Drugs 120
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First 'warm-blooded' dinosaurs may have emerged 180 million years ago

Science Daily: Pharmacology News

The ability to regulate body temperature, a trait all mammals and birds have today, may have evolved among some dinosaurs early in the Jurassic period about 180 million years ago. The new study looked at the spread of dinosaurs across different climates on Earth throughout the Mesozoic Era (the dinosaur era lasting from 230 to 66 million years ago), drawing on 1,000 fossils, climate models and the geography of the period, and dinosaurs' evolutionary trees.

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Avian Flu Virus Showing Up in NYC Wild Birds

Drugs.com

WEDNESDAY, May 15, 2024 -- The H5N1 avian flu virus has been discovered in a small number of wild birds in New York City.The highly infectious and severe virus was detected in fecal samples in six New York City birds representing four different.

Virus 115
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Meet the researcher: Dr Henrik Jespersen

Drug Discovery World

DDW’s Megan Thomas talks to Dr Henrik Jespersen, Head of Melanoma Oncology, at Oslo University Hospital. MT: Where do you work, and can you tell us what you’re working on at the moment? HJ: I work as a clinical oncologist at Oslo University Hospital where I am head of melanoma oncology. I have a particular interest in tumour immunology and the melanoma subtype that arises in parts of the eye called uveal melanoma.

Research 147
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When Worlds Collide: The Theory of Real-World Evidence Meets Reality

FDA Law Blog: Biosimilars

By Jeffrey N. Gibbs & Ana Loloei & Véronique Li, Senior Medical Device Regulation Expert — FDA has long touted the use of real-world evidence ( RWE ). Extolling RWE, FDA has said “RWE can be leveraged to bring new products to market, evaluate the safety and effectiveness of existing products for new uses, and assess the continued performance and safety of products once on the market.

FDA 111
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People without an inner voice have poorer verbal memory

Science Daily: Pharmacology News

The vast majority of people have an ongoing conversation with themselves, an inner voice, that plays an important role in their daily lives. But between 5-10 per cent of the population do not have the same experience of an inner voice, and they find it more difficult to perform certain verbal memory tasks, new research shows.

Research 117
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Leptospirosis: What Every Dog Owner Should Know

Drugs.com

FRIDAY, May 17, 2024 -- Mice, rats and other wildlife can pick up bacteria called leptospira from water or soil and excrete it in urine. If your dog contacts any soil or water contaminated by the germ (especially if they have an open wound) they.

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New podcast: A new paradigm of appetite and hunger

Drug Discovery World

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Tien Lee, CEO of Aardvark Therapeutics, a San Diego-based biotech company in Phase II studies of its drug, ARD-101, a type 2 bitter taste receptor (TAS2R) which is taken orally and remains in the human gut unlike GLP-1 which is systemic.

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Navigating Trust and Data in Healthcare Marketing

Perficient: Drug Development

In the ever-evolving landscape of healthcare, trust reigns supreme. As consumers increasingly rely on data to inform their decisions, the healthcare industry faces a pressing need to not only meet but exceed expectations. With disruptive forces emerging from various corners, healthcare organizations find themselves in a race to create personalized experiences that foster lasting engagement and trust.

Marketing 111
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Animal brain inspired AI game changer for autonomous robots

Science Daily: Pharmacology News

A team of researchers has developed a drone that flies autonomously using neuromorphic image processing and control based on the workings of animal brains. Animal brains use less data and energy compared to current deep neural networks running on GPUs (graphic chips). Neuromorphic processors are therefore very suitable for small drones because they don't need heavy and large hardware and batteries.

Research 113
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Most Cancer Treatments Near End of Life Are Useless: Study

Drugs.com

FRIDAY, May 17, 2024 -- Cutting-edge cancer treatments are essentially useless for patients barely clinging to life, a new study shows.Chemotherapies, immunotherapies, targeted therapies and hormone therapies do not improve survival rates in.

Treatment 111
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New DDW Highlights episode: 8 May 2024

Drug Discovery World

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. A leading news story this week has been the announcement of positive Phase II results of a head and neck cancer trial, but there have been a number of other interesting clinical result announcements.

Trials 147
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Detailed trial data show Bayer drug alleviates menopause symptoms

BioPharma Drive: Drug Pricing

Full study results disclosed ahead of a medical meeting showed elinzanetant consistently reduced the frequency and severity of hot flashes.

Trials 120
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Plant virus treatment shows promise in fighting metastatic cancers in mice

Science Daily: Pharmacology News

An experimental treatment made from a plant virus is effective at protecting against a broad range of metastatic cancers in mice, shows a new study. The treatment, composed of nanoparticles fashioned from the cowpea mosaic virus -- a virus that infects black-eyed pea plants -- showed remarkable success in improving survival rates and suppressing the growth of metastatic tumors across various cancer models, including colon, ovarian, melanoma and breast cancer.

Virus 116
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Lymphoma: Know Your Treatment Options

Drugs.com

THURSDAY, May 16, 2024 -- For anyone newly diagnosed with blood cancers known as lymphomas, their first question might be: What treatments can help?Of course, there have been big advances in chemotherapy against the disease, but treatments now go.

Treatment 111
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How structural biology is informing vaccine design

Drug Discovery World

Reece Armstrong speaks to Melanie Adams-Cioaba , Senior Director and General Manager of pharma (cryo-EM), Thermo Fisher Scientific about advances in vaccine design. RA: How can rational design approaches help advance vaccine development? MA: Regarding vaccine development specifically, and the role my team plays in the development of cryogenic electron microscopy (cryo-EM) technology, we see the study and dissemination of virus structures, and the proteins that comprise them, as vital to vacc

Vaccine 147
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Perficient Earns Data Cloud Expert Specialization

Perficient: Drug Development

We’re excited to announce our Data Cloud Expert specialization! This is the highest level of Salesforce-validated expertise for Data Cloud. This achievement isn’t just a milestone, it’s a testament to our commitment to revolutionizing how businesses leverage their data to drive business outcomes, unlock trapped data, and enhance customer experiences.

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Robots' and prosthetic hands' sense of touch could be as fast as humans

Science Daily: Pharmacology News

Research could pave the way for a prosthetic hand and robot to be able to feel touch like a human hand. The technology could also be used to help restore lost functionality to patients after a stroke.

Research 112