Sat.May 11, 2024 - Fri.May 17, 2024

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Investors put $400M into biotech licensing obesity drugs from China

BioPharma Drive: Drug Pricing

The biotech, tentatively named Hercules CM Newco, has rights to three incretin drugs discovered by Jiangsu Hengrui Pharmaceuticals, two of which are in clinical testing.

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Scientists generate heat over 1,000 degrees Celsius with solar power instead of fossil fuel

Science Daily: Pharmacology News

Instead of burning fossil fuels to smelt steel and cook cement, researchers in Switzerland want to use heat from the sun. The proof-of-concept study uses synthetic quartz to trap solar energy at temperatures over 1,000 C (1,832 F), demonstrating the method's potential role in providing clean energy for carbon-intensive industries.

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Early Hints at a Gene Therapy Cure for Herpes

Drugs.com

WEDNESDAY, May 15, 2024 -- An experimental gene therapy could one day provide a first-ever cure for genital and oral herpes, researchers report.The gene therapy removed 90% or more of oral herpes infection in lab mice, and it also suppressed how.

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CDD Vault Update (May 2024 #2)

Collaborative Drug

View assay ontology branches Protocol forms in CDD Vault facilitate assay informatics. Vault administrators create protocol forms under the Settings->Vault->Protocol Forms page. Utilize fields from two public ontologies: ‘Common assay template’ and ‘Pistoia Alliance assay template’. Click the ‘view’ link next to the field name to see the terms for that specific branch.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Ajax, aiming for a better JAK drug, raises $95M to begin first tests

BioPharma Drive: Drug Pricing

Goldman Sachs and Eli Lilly are among those backing the startup, which claims its prospect could be more potent than the myelofibrosis therapies that have come to market in recent years.

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A simple quantum internet with significant possibilities

Science Daily: Pharmacology News

It's one thing to dream up a quantum internet that could send hacker-proof information around the world via photons superimposed in different quantum states. It's quite another to physically show it's possible. That's exactly what physicists have done, using existing Boston-area telecommunication fiber, in a demonstration of the world's longest fiber distance between two quantum memory nodes to date.

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New gene delivery vehicle shows promise for human brain gene therapy

Broad Institute

New gene delivery vehicle shows promise for human brain gene therapy By Allessandra DiCorato May 16, 2024 Breadcrumb Home New gene delivery vehicle shows promise for human brain gene therapy Scientists have engineered an adeno-associated virus (AAV) that efficiently crosses the blood-brain barrier in human cell models and delivers genes throughout the brain in humanized mice.

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Biogen, Ionis shelve ALS drug following study failure

BioPharma Drive: Drug Pricing

While results indicated the drug works as intended, it didn’t have enough of an effect on a protein that’s become integral to many ALS research programs.

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Today's world: Fastest rate of carbon dioxide rise over the last 50,000 years

Science Daily: Pharmacology News

Today's rate of atmospheric carbon dioxide increase is 10 times faster than at any other point in the past 50,000 years, researchers have found through a detailed chemical analysis of ancient Antarctic ice.

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Avian Flu Virus Showing Up in NYC Wild Birds

Drugs.com

WEDNESDAY, May 15, 2024 -- The H5N1 avian flu virus has been discovered in a small number of wild birds in New York City.The highly infectious and severe virus was detected in fecal samples in six New York City birds representing four different.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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When Worlds Collide: The Theory of Real-World Evidence Meets Reality

FDA Law Blog: Biosimilars

By Jeffrey N. Gibbs & Ana Loloei & Véronique Li, Senior Medical Device Regulation Expert — FDA has long touted the use of real-world evidence ( RWE ). Extolling RWE, FDA has said “RWE can be leveraged to bring new products to market, evaluate the safety and effectiveness of existing products for new uses, and assess the continued performance and safety of products once on the market.

FDA
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Detailed trial data show Bayer drug alleviates menopause symptoms

BioPharma Drive: Drug Pricing

Full study results disclosed ahead of a medical meeting showed elinzanetant consistently reduced the frequency and severity of hot flashes.

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First 'warm-blooded' dinosaurs may have emerged 180 million years ago

Science Daily: Pharmacology News

The ability to regulate body temperature, a trait all mammals and birds have today, may have evolved among some dinosaurs early in the Jurassic period about 180 million years ago. The new study looked at the spread of dinosaurs across different climates on Earth throughout the Mesozoic Era (the dinosaur era lasting from 230 to 66 million years ago), drawing on 1,000 fossils, climate models and the geography of the period, and dinosaurs' evolutionary trees.

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Leptospirosis: What Every Dog Owner Should Know

Drugs.com

FRIDAY, May 17, 2024 -- Mice, rats and other wildlife can pick up bacteria called leptospira from water or soil and excrete it in urine. If your dog contacts any soil or water contaminated by the germ (especially if they have an open wound) they.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Navigating Trust and Data in Healthcare Marketing

Perficient: Drug Development

In the ever-evolving landscape of healthcare, trust reigns supreme. As consumers increasingly rely on data to inform their decisions, the healthcare industry faces a pressing need to not only meet but exceed expectations. With disruptive forces emerging from various corners, healthcare organizations find themselves in a race to create personalized experiences that foster lasting engagement and trust.

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Lilly’s once-weekly insulin matches daily shots in late-stage tests

BioPharma Drive: Drug Pricing

The results, which showed Lilly’s drug was as effective at controlling blood sugar as standard injections, come as Novo Nordisk seeks approval for a competing once-weekly insulin.

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People without an inner voice have poorer verbal memory

Science Daily: Pharmacology News

The vast majority of people have an ongoing conversation with themselves, an inner voice, that plays an important role in their daily lives. But between 5-10 per cent of the population do not have the same experience of an inner voice, and they find it more difficult to perform certain verbal memory tasks, new research shows.

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Most Cancer Treatments Near End of Life Are Useless: Study

Drugs.com

FRIDAY, May 17, 2024 -- Cutting-edge cancer treatments are essentially useless for patients barely clinging to life, a new study shows.Chemotherapies, immunotherapies, targeted therapies and hormone therapies do not improve survival rates in.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Antibodies 101: Flow Compensation

addgene Blog

In flow cytometry, compensation is the process of correcting spillover from one fluorescent channel to another. When you label your samples with multiple antibodies, the fluorescent probes on the antibodies may have similar emission spectra, meaning they will emit fluorescent light at similar wavelengths (See this handy emission spectra chart to find your antibody's spectra ).

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Eisai sets new revenue target for Alzheimer’s drug Leqembi

BioPharma Drive: Drug Pricing

The annual forecast, which comes as Eisai and Biogen have begun submitting a more convenient form of Leqembi for approval, looks “more realistic” than previous guidance, according to Jefferies analysts.

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Plant virus treatment shows promise in fighting metastatic cancers in mice

Science Daily: Pharmacology News

An experimental treatment made from a plant virus is effective at protecting against a broad range of metastatic cancers in mice, shows a new study. The treatment, composed of nanoparticles fashioned from the cowpea mosaic virus -- a virus that infects black-eyed pea plants -- showed remarkable success in improving survival rates and suppressing the growth of metastatic tumors across various cancer models, including colon, ovarian, melanoma and breast cancer.

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Why C-Section Babies Need 2 Doses of Measles Vaccine

Drugs.com

TUESDAY, May 14, 2024 -- Babies born by C-section are unlikely to receive protection from a single dose of measles vaccine, a new study finds.A single measles jab is up to 2.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Plasmids 101: Modular Cloning Applications and Kits

addgene Blog

Modular cloning is a popular DNA assembly tool used to build single- and multi-gene constructs for a variety of applications. MoClo tools can be used in bacterial and cell-free expression systems, mammalian cells, yeast, flies, and even plants! In this blog we will review common uses of MoClo and the kits Addgene offers to kickstart these applications, no matter what your model organism is.

DNA
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FogPharma, Artbio join forces to design a different radiopharma drug

BioPharma Drive: Drug Pricing

The biotechs aim to marry FogPharma’s polypeptide science with Artbio’s lead-based radiopharmaceutical technology in one of the industry’s hottest fields.

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Global life expectancy to increase by nearly 5 years by 2050 despite geopolitical, metabolic, and environmental threats

Science Daily: Pharmacology News

The latest findings forecast that global life expectancy will increase by 4.9 years in males and 4.2 years in females between 2022 and 2050. Increases are expected to be largest in countries where life expectancy is lower, contributing to a convergence of increased life expectancy across geographies. The trend is largely driven by public health measures that have prevented and improved survival rates from cardiovascular diseases, COVID-19, and a range of communicable, maternal, neonatal, and nut

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Surgical Outcomes Better With More Women on Your Team

Drugs.com

WEDNESDAY, May 15, 2024 -- Heading for surgery? The ratio of women to men in the operating room could influence your recovery, new research shows.Hospitals in Canada that had 35% or more surgeons and anesthesiologists who were female on staff.

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New patent for Mallinckrodt Hosp drug INOMAX

Drug Patent Watch

Annual Drug Patent Expirations for INOMAX Inomax is a drug marketed by Mallinckrodt Hosp and is included in one NDA. It is available from one supplier.

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Sanofi gambles $80M on Fulcrum’s muscular dystrophy drug

BioPharma Drive: Drug Pricing

The deal gives the pharma partial rights to a medicine GSK once developed for heart disease but could soon become the first therapy for facioscapulohumeral muscular dystrophy.

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2023 was the hottest summer in two thousand years

Science Daily: Pharmacology News

Researchers have found that 2023 was the hottest summer in the Northern Hemisphere in the past two thousand years, almost four degrees warmer than the coldest summer during the same period.

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Lymphoma: Know Your Treatment Options

Drugs.com

THURSDAY, May 16, 2024 -- For anyone newly diagnosed with blood cancers known as lymphomas, their first question might be: What treatments can help?Of course, there have been big advances in chemotherapy against the disease, but treatments now go.

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Evaluation of a panel of furochromenones as the activator and inhibitor of tyrosinase

Chemical Biology and Drug Design

The study screened and identified furochromenones that impact tyrosinase activity. One of the furochromenones ( 3k ) inhibited while another ( 4f ) stimulated tyrosinase. Abstract Tyrosinase is a copper-containing enzyme involved in the biosynthesis of melanin pigment. While the excess production of melanin causes hyperpigmentation of human skin, hypopigmentation results in medical conditions like vitiligo.

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FDA approves Amgen drug for tough-to-treat form of lung cancer

BioPharma Drive: Drug Pricing

Imdelltra, a bispecific antibody targeting a protein called DLL3, is cleared for use following chemotherapy in treating extensive-stage small cell lung cancer.