Sat.Jan 04, 2025 - Fri.Jan 10, 2025

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Some GLP-1s Achieve More Weight Loss Than Others: Study

Drugs.com

WEDNESDAY, Jan. 8, 2025 -- Three GLP-1 drugs are best at helping obese and overweight people drop weight, including one that hasnt yet been approved for that purpose.A new evidence review published in the Annals of Internal Medicine shows that the.

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Evolutionary biology: Ants can hold a grudge

Science Daily: Pharmacology News

Evolutionary biologists are investigating the extent to which ants learn from past experiences. After being attacked by ants from a particular nest, ants behave more aggressively towards others from that same nest.

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Researchers devise new way to target and correct disease-related proteins

Broad Institute

Researchers devise new way to target and correct disease-related proteins By Leah Eisenstadt January 6, 2025 Breadcrumb Home Researchers devise new way to target and correct disease-related proteins Broad scientists built a diverse library of compounds and found one that stabilizes a dysfunctional protein in Crohns disease, demonstrating their librarys potential to uncover new therapeutic strategies.

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FDA adds warning to RSV shots from GSK, Pfizer

BioPharma Drive: Drug Pricing

The regulator is requiring labeling that warns of Guillan-Barré syndrome, although it said data don’t prove a causal link and affirmed the shots’ benefit outweighs their risks.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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U.S. Whooping Cough Cases Surge

Drugs.com

MONDAY, Jan. 6, 2025 -- Rates of whooping cough in the U.S. continue to climb, according to data from the US Centers for Disease Control (CDC).Over 32,000 cases reported have been reported as of mid-December -- about six times more than there were.

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Scientists engineer CRISPR enzymes that evade the immune system

Broad Institute

Scientists engineer CRISPR enzymes that evade the immune system By Allessandra DiCorato January 9, 2025 Breadcrumb Home Scientists engineer CRISPR enzymes that evade the immune system The new genome-editing tools could lead to safer, more efficient gene therapies. By Allessandra DiCorato January 9, 2025 Credit: Natalie Velez, Broad Communications Related news Researchers uncover new CRISPR-like system in animals that can edit the human genome The core components of CRISPR-based genome-editing th

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ALS drugs from Denali, Calico come up short, marking more failures for Healey trial

BioPharma Drive: Drug Pricing

Denali’s medicine and a similar one from Calico Life Sciences and AbbVie were not much different than a placebo, bringing the tally of failed drugs in the innovative “Healey platform trial” to seven.

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Non-Opioids Can Ease Post-Dental Surgery Pain Better Than Opioids, Study Shows

Drugs.com

THURSDAY, Jan. 9, 2025 -- Over-the-counter (OTC) drugs acetaminophen and ibuprofen are better at managing dental pain than opioids.People who had their wisdom teeth removed got better results from an acetaminophen/ibuprofen combo than with a.

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How deep sleep clears a mouse's mind, literally

Science Daily: Pharmacology News

A good night's sleep does more than just help you feel rested--it might literally clear your mind. A new study shows how deep sleep may wash away waste buildup in the brain during waking hours, an essential process for maintaining brain health. The findings also offer insights into how sleep aids may disrupt the 'brainwashing' system, potentially affecting cognitive function in the long run.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Feng Zhang awarded the National Medal of Technology and Innovation

Broad Institute

Feng Zhang awarded the National Medal of Technology and Innovation By Corie Lok January 6, 2025 Breadcrumb Home Feng Zhang awarded the National Medal of Technology and Innovation Zhang and 22 other individuals received the USs highest honors for science and technology. By Broad Communications January 6, 2025 Credit: Ryan K. Morris Feng Zhang receives the National Medal of Technology and Innovation at the White House from Arati Prabhakar (left), director of the White House Office of Science and T

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Vertex, startup Orna to partner on gene editing research

BioPharma Drive: Drug Pricing

The three-year partnership is another example of Vertex’s interest in improving on Casgevy, its CRISPR medicine for sickle cell and beta thalassemia.

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Despite Previous Data, Paxlovid May Be Useful for Long Covid After All

Drugs.com

WEDNESDAY, Jan. 8, 2024 -- The antiviral pill Paxlovid might help some patients who are suffering from long COVID.A five-day course of Paxlovid is known to help limit symptoms and shorten illness in patients during an initial bout of COVID-19.

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Feeding your good gut bacteria through fiber in diet may boost body against infections

Science Daily: Pharmacology News

A new study has found that the composition of your gut microbiome helps predict how likely you are to succumb to potentially life-threatening infection with Klebsiella pneumoniae, E.coli and other bugs -- and it may be altered by changing your diet.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Drug Discovery Industry Roundup with Barry Bunin — January 9th, 2025

Collaborative Drug

Drug Discovery Industry Roundup with Barry Bunin January 9th, 2025

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Orbis raises $93M to turn popular biologics into pills

BioPharma Drive: Drug Pricing

The startup is developing a kind of macrocyles, which share strengths of both small molecules and biologics, as oral medicines against “validated blockbuster biologic targets.

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Health Advocates Are Unhappy with FDA Guidance on Lead Levels in Baby Food

Drugs.com

TUESDAY, Jan. 7, 2025 -- The U.S. Food and Drug Association (FDA) released the first-ever guidelines for levels of lead in processed baby foods this week. However, many health and safety advocates say they are not satisfied with the guidance.Under.

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'What is that?' Scientists explain white patch that appears near northern lights

Science Daily: Pharmacology News

A whitish, grey patch that sometimes appears in the night sky alongside the northern lights has now been explained.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Biological Characterization of One Oxadiazole Derivative (5(4‐Hydroxyphenyl)‐2‐(N‐Phenyl Amino)‐1,3,4‐Oxadiazole): In Vitro, In Silico, and Network Pharmacological Approaches

Chemical Biology and Drug Design

5(4-Hydroxyphenyl)-2-(N-Phenyl amino)-1,3,4-Oxadiazole (Hppo) can considered as a versatile agent in designing novel pharmaceuticals. ABSTRACT Oxadiazole compounds are of great interest because they have a range of biological activities ranging from antioxidants to anticancer agents. Against this background, we wanted to demonstrate the antioxidant, enzyme inhibitory, and anticancer effects of 5(4-hydroxyphenyl)-2-(N-phenylamino)-1,3,4-oxadiazole (Hppo).

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Patrizia Cavazzoni, key FDA official, to leave agency

BioPharma Drive: Drug Pricing

The director of the FDA's main drug review office will exit on Jan. 18, according to an email sent to staff. Her departure is one of several announced by high-ranking FDA leaders ahead of the coming administration change.

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Can Elderberry Juice Help You Lose Weight?

Drugs.com

FRIDAY, Jan. 10, 2025 -- Ozempic? Wegovy? Zepbound?How about elderberry juice?Elderberry juice might help people lose weight and improve their blood sugar control, a new small-scale study says.People who drank 12 ounces of elderberry juice daily.

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Tuberculosis strains resistant to new drugs are transmitted between patients

Science Daily: Pharmacology News

Tuberculosis (TB) is the world's biggest infectious disease killer with multidrug-resistant TB (MDR-TB) posing a particular threat to global health. A study shows that resistance to the new MDR-TB treatment regimen recently recommended by the World Health Organization is already spreading between patients.

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Edwin Cohn and the Harvard Blood Factory

Codon

Today we launch Issue 05 of Asimov Press. Read our full Editors’ Note and preview upcoming articles on our website. Thanks for reading! Edwin Cohn, a temperamental and entrepreneurial protein chemist working at Harvard University in the early 1900s, is perhaps one of the most underrated translational scientists of all time. In 1940, with the likelihood of America’s involvement in World War II steadily rising, the U.S. military approached Cohn about developing medical products from bl

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Metsera reveals study data supporting long-acting obesity shot

BioPharma Drive: Drug Pricing

The startup, which has already raised more than half a billion dollars, released Phase 2 results that could position its drug as a future threat to weight loss medicines from Novo Nordisk and Eli Lilly.

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Blood Test May Help Predict How Long Immunity Lasts

Drugs.com

TUESDAY, Jan. 7, 2024 -- Its long been a mystery why folks need a flu vaccine every year, even though immunizations they got in childhood continue to protect them from measles and mumps.Researchers now think they know why vaccine effectiveness v.

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Disovery of new skeletal tissue advances regenerative medicine potential

Science Daily: Pharmacology News

An international research team has discovered a new type of skeletal tissue that offers great potential for advancing regenerative medicine and tissue engineering.

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Inflation-Adjusted U.S. Brand-Name Drug Prices Fell for the Seventh Consecutive Year as a New Era of Drug Pricing Dawns

Drug Channels

It's time for Drug Channels annual examination of U.S. brand-name drug pricing. For 2024, average brand-name drugs list prices grew by only 2.3%. Whats more, after adjusting for overall inflation, brand-name drug net prices dropped for an unprecedented seventh consecutive year. Details and additional commentary below. As I predicted two years ago , the combined impact of changes to Medicaid rebates, the Inflation Reduction Act (IRA), and novel formulary access strategies have led multiple m

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Navigating future biopharma catalysts: What to expect at the 2025 J.P. Morgan Healthcare Conference

BioPharma Drive: Drug Pricing

The stage is set for JPM 2025—don't miss expert reactions following 2025’s principal catalyst event!

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Early Physical Therapy Key for Concussion Recovery, Study Shows

Drugs.com

MONDAY, Jan 6, 2025 -- Turns out, starting physical therapy earlier after a concussion may significantly improve recovery outcomes.A new study published recently in the Physical Therapy & Rehabilitation Journal followed just over 200 adults.

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Non-opioid pain relievers beat opioids after dental surgery

Science Daily: Pharmacology News

Researchers find an over-the-counter combo is more effective for wisdom tooth extraction pain.

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AI Unleashed: Transforming Drug Discovery from Theory to Practice

Plenge Gen

When I last wrote about AI on this blog three years ago, I spoke of it being a tool with the potential to transform scientific discovery, but the application I described was primarily theoretical. For AI to be a meaningful tool in R&D, I argued, we needed better sources of truth better data sets that AI tools could query and learn from over time and technology capable of integrating multiples steps into a semi-automated system.

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