Drugs.com
JANUARY 8, 2025
WEDNESDAY, Jan. 8, 2025 -- Three GLP-1 drugs are best at helping obese and overweight people drop weight, including one that hasnt yet been approved for that purpose.A new evidence review published in the Annals of Internal Medicine shows that the.
Science Daily: Pharmacology News
JANUARY 8, 2025
Evolutionary biologists are investigating the extent to which ants learn from past experiences. After being attacked by ants from a particular nest, ants behave more aggressively towards others from that same nest.
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Broad Institute
JANUARY 6, 2025
Researchers devise new way to target and correct disease-related proteins By Leah Eisenstadt January 6, 2025 Breadcrumb Home Researchers devise new way to target and correct disease-related proteins Broad scientists built a diverse library of compounds and found one that stabilizes a dysfunctional protein in Crohns disease, demonstrating their librarys potential to uncover new therapeutic strategies.
Covalent Modifiers
JANUARY 9, 2025
Tomonori Tamura, Masaharu Kawano, and Itaru Hamachi Chemical Reviews 2024 DOI: 10.1021/acs.chemrev.4c00745 The term undruggable refers to proteins or other biological targets that have been historically challenging to target with conventional drugs or therapeutic strategies because of their structural, functional, or dynamic properties. Drugging such undruggable targets is essential to develop new therapies for diseases where current treatment options are limited or nonexistent.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
BioPharma Drive: Drug Pricing
JANUARY 8, 2025
The regulator is requiring labeling that warns of Guillan-Barré syndrome, although it said data don’t prove a causal link and affirmed the shots’ benefit outweighs their risks.
Science Daily: Pharmacology News
JANUARY 9, 2025
Construction materials such as concrete and plastic have the potential to lock away billions of tons of carbon dioxide, according to a new study by civil engineers and earth systems scientists. The study shows that combined with steps to decarbonize the economy, storing CO2 in buildings could help the world achieve goals for reducing greenhouse gas emissions.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Covalent Modifiers
JANUARY 9, 2025
Matthew Bogyo, Tulsi Upadhyay, Emily Woods, Stephen Ahator. Kjersti Julin, Franco Faucher, Marijn Hollander, Nichole Pedowitz, Daniel Abegg, Isabella Hammond, Ifeanyichukwu Eke, Sijie Wang, Shiyu Chen, John Bennett, Jeyun Jo, Christian Lentz, Alex Adibekian, Matthias Fellner Research Square Preprint 2025 [link] 10.21203/rs.3.rs-5494070/v1 Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide.
BioPharma Drive: Drug Pricing
JANUARY 7, 2025
Denali’s medicine and a similar one from Calico Life Sciences and AbbVie were not much different than a placebo, bringing the tally of failed drugs in the innovative “Healey platform trial” to seven.
Science Daily: Pharmacology News
JANUARY 8, 2025
A good night's sleep does more than just help you feel rested--it might literally clear your mind. A new study shows how deep sleep may wash away waste buildup in the brain during waking hours, an essential process for maintaining brain health. The findings also offer insights into how sleep aids may disrupt the 'brainwashing' system, potentially affecting cognitive function in the long run.
Broad Institute
JANUARY 6, 2025
Feng Zhang awarded the National Medal of Technology and Innovation By Corie Lok January 6, 2025 Breadcrumb Home Feng Zhang awarded the National Medal of Technology and Innovation Zhang and 22 other individuals received the USs highest honors for science and technology. By Broad Communications January 6, 2025 Credit: Ryan K. Morris Feng Zhang receives the National Medal of Technology and Innovation at the White House from Arati Prabhakar (left), director of the White House Office of Science and T
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Covalent Modifiers
JANUARY 7, 2025
Tomonori Tamura and Itaru Hamachi Accounts of Chemical Research 2025 58 (1), 87-100 DOI: 10.1021/acs.accounts.4c00628 Selective chemical modification of endogenous proteins in living systems with synthetic small molecular probes is a central challenge in chemical biology. Such modification has a variety of applications important for biological and pharmaceutical research, including protein visualization, protein functionalization, proteome-wide profiling of enzyme activity, and irreversible inhi
BioPharma Drive: Drug Pricing
JANUARY 7, 2025
The three-year partnership is another example of Vertex’s interest in improving on Casgevy, its CRISPR medicine for sickle cell and beta thalassemia.
Science Daily: Pharmacology News
JANUARY 10, 2025
A whitish, grey patch that sometimes appears in the night sky alongside the northern lights has now been explained.
Drugs.com
JANUARY 6, 2025
MONDAY, Jan. 6, 2025 -- Rates of whooping cough in the U.S. continue to climb, according to data from the US Centers for Disease Control (CDC).Over 32,000 cases reported have been reported as of mid-December -- about six times more than there were.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Collaborative Drug
JANUARY 9, 2025
Drug Discovery Industry Roundup with Barry Bunin January 9th, 2025
BioPharma Drive: Drug Pricing
JANUARY 6, 2025
The startup is developing a kind of macrocyles, which share strengths of both small molecules and biologics, as oral medicines against “validated blockbuster biologic targets.
Science Daily: Pharmacology News
JANUARY 10, 2025
A new study has found that the composition of your gut microbiome helps predict how likely you are to succumb to potentially life-threatening infection with Klebsiella pneumoniae, E.coli and other bugs -- and it may be altered by changing your diet.
Drugs.com
JANUARY 9, 2025
THURSDAY, Jan. 9, 2025 -- Over-the-counter (OTC) drugs acetaminophen and ibuprofen are better at managing dental pain than opioids.People who had their wisdom teeth removed got better results from an acetaminophen/ibuprofen combo than with a.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Chemical Biology and Drug Design
JANUARY 5, 2025
5(4-Hydroxyphenyl)-2-(N-Phenyl amino)-1,3,4-Oxadiazole (Hppo) can considered as a versatile agent in designing novel pharmaceuticals. ABSTRACT Oxadiazole compounds are of great interest because they have a range of biological activities ranging from antioxidants to anticancer agents. Against this background, we wanted to demonstrate the antioxidant, enzyme inhibitory, and anticancer effects of 5(4-hydroxyphenyl)-2-(N-phenylamino)-1,3,4-oxadiazole (Hppo).
BioPharma Drive: Drug Pricing
JANUARY 10, 2025
The director of the FDA's main drug review office will exit on Jan. 18, according to an email sent to staff. Her departure is one of several announced by high-ranking FDA leaders ahead of the coming administration change.
Science Daily: Pharmacology News
JANUARY 6, 2025
Tuberculosis (TB) is the world's biggest infectious disease killer with multidrug-resistant TB (MDR-TB) posing a particular threat to global health. A study shows that resistance to the new MDR-TB treatment regimen recently recommended by the World Health Organization is already spreading between patients.
Drugs.com
JANUARY 8, 2025
WEDNESDAY, Jan. 8, 2024 -- The antiviral pill Paxlovid might help some patients who are suffering from long COVID.A five-day course of Paxlovid is known to help limit symptoms and shorten illness in patients during an initial bout of COVID-19.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
FDA Law Blog: Biosimilars
JANUARY 9, 2025
By Anne K. Walsh & Hyman, Phelps & McNamara, P.C. & Douglas B. Farquhar This is the first in a series of blog posts on tips for successfully handling an FDA inspection. Using publicly available examples, these lessons will illustrate potential pitfalls and strategies for interacting with FDA during and after an inspection. Although FDA has long taken the position that it has broad authority in how it conducts its inspections, it was not until 2012 that Congress put some teeth behind
BioPharma Drive: Drug Pricing
JANUARY 6, 2025
The stage is set for JPM 2025—don't miss expert reactions following 2025’s principal catalyst event!
Science Daily: Pharmacology News
JANUARY 6, 2025
Researchers find an over-the-counter combo is more effective for wisdom tooth extraction pain.
Drugs.com
JANUARY 7, 2025
TUESDAY, Jan. 7, 2025 -- The U.S. Food and Drug Association (FDA) released the first-ever guidelines for levels of lead in processed baby foods this week. However, many health and safety advocates say they are not satisfied with the guidance.Under.
Drug Channels
JANUARY 7, 2025
It's time for Drug Channels annual examination of U.S. brand-name drug pricing. For 2024, average brand-name drugs list prices grew by only 2.3%. Whats more, after adjusting for overall inflation, brand-name drug net prices dropped for an unprecedented seventh consecutive year. Details and additional commentary below. As I predicted two years ago , the combined impact of changes to Medicaid rebates, the Inflation Reduction Act (IRA), and novel formulary access strategies have led multiple m
BioPharma Drive: Drug Pricing
JANUARY 7, 2025
The startup, which has already raised more than half a billion dollars, released Phase 2 results that could position its drug as a future threat to weight loss medicines from Novo Nordisk and Eli Lilly.
Science Daily: Pharmacology News
JANUARY 9, 2025
An international research team has discovered a new type of skeletal tissue that offers great potential for advancing regenerative medicine and tissue engineering.
Drugs.com
JANUARY 10, 2025
FRIDAY, Jan. 10, 2025 -- Ozempic? Wegovy? Zepbound?How about elderberry juice?Elderberry juice might help people lose weight and improve their blood sugar control, a new small-scale study says.People who drank 12 ounces of elderberry juice daily.
Plenge Gen
JANUARY 7, 2025
When I last wrote about AI on this blog three years ago, I spoke of it being a tool with the potential to transform scientific discovery, but the application I described was primarily theoretical. For AI to be a meaningful tool in R&D, I argued, we needed better sources of truth better data sets that AI tools could query and learn from over time and technology capable of integrating multiples steps into a semi-automated system.
BioPharma Drive: Drug Pricing
JANUARY 9, 2025
The biotech will stop developing two drugs and lay off nearly three-quarters of its staff after its lead therapy wasn’t as potent in early testing as the company expected.
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