Sat.Jul 29, 2023 - Fri.Aug 04, 2023

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Troubled Childhood Could Mean a Troubled Old Age, Study Finds

Drugs.com

FRIDAY, Aug. 4, 2023 -- The trauma and unhappy family dynamics of childhood may follow kids into old age, affecting both their mind and body, according to new research. “We looked at self-reported disability, as well as objectively measured.

Research 246
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Amgen says KRAS drug met goal in late-stage colon cancer trial

BioPharma Drive: Drug Pricing

The company disclosed the study result alongside second quarter earnings showing Lumakras sales were flat versus the same period one year prior.

Trials 246
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CDD Vault Update (August 2023)

Collaborative Drug

Atropisomer Registration in CDD Vault CDD Chemistry now provides a unique, efficient, and robust way of registering atropisomers. Distinct atropisomers can be drawn and registered into CDD Vault as separate Molecules with unique IDs.

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New exoplanet discovery builds better understanding of planet formation

Science Daily: Pharmacology News

An international team of scientists have discovered an unusual Jupiter-sized planet orbiting a low-mass star called TOI-4860, located in the Corvus constellation.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Lawsuit Against Makers of Ozempic, Mounjaro Claim Meds Caused 'Stomach Paralysis'

Drugs.com

THURSDAY, Aug. 3, 2023 -- A Louisiana woman is suing the makers of two type 2 diabetes drugs used off-label for obesity, saying they failed to adequately warn about the risk of severe stomach problems. The lawsuit seeks “very.

Drugs 246

More Trending

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Recorded Webinar: Streamlining Collaborations and Drug Development using CDD Vault

Collaborative Drug

Streamlining Collaborations and Drug Development using CDD Vault and ELN

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Social media algorithms exploit how humans learn from their peers

Science Daily: Pharmacology News

In prehistoric societies, humans tended to learn from members of our ingroup or from more prestigious individuals, as this information was more likely to be reliable and result in group success. However, with the advent of diverse and complex modern communities -- and especially in social media -- these biases become less effective. For example, a person we are connected to online might not necessarily be trustworthy, and people can easily feign prestige on social media.

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Yoga Might Do Wonders for Women's Aging Brains

Drugs.com

THURSDAY, Aug. 3, 2023 -- Yoga is known for its benefits to both the mind and body. And a gentle form of yoga may be an ideal early intervention technique for older women at risk of Alzheimer's disease, new research suggests. In a small study.

Disease 246
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A once buzzy gene therapy startup lays off staff and shuts down

BioPharma Drive: Drug Pricing

Intergalactic, a developer of non-viral gene therapies built by ex-Biogen executive Michael Ehlers, is folding less than two years after its launch.

Therapies 246
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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CDD Exhibiting and Presenting at ACS Fall 2023, August 13th to 17th

Collaborative Drug

CDD Exhibiting and Presenting at ACS Fall 2023, August 13th to 17th.

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Scientists uncover a startling--and exploitable--coordination of gene expression in tumors

Science Daily: Pharmacology News

A new study has identified a pair of genes whose expression by a type of immune cell within tumors is predictive of outcomes for cancer patients and is linked to a vast network of gene expression programs, engaged by multiple cell types in the tumor microenvironment, that control human cancers.

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Taking Kratom Claimed Her Son's Life. Now She and Others Are Warning of the Dangers

Drugs.com

THURSDAY, Aug. 3, 2023 -- J.D. Butler was planning a future with his girlfriend at his favorite New York City restaurant when that future came to a sudden, crushing halt. “They were planning on when she was moving in and arranging floor plans on.

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Sarepta offers early look at closely watched gene therapy launch

BioPharma Drive: Drug Pricing

One patient received its Duchenne gene therapy, Elevidys, this week and a handful more could follow shortly, surprising some analysts and raising near-term sales expectations.

Therapies 246
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Structural and functional fine mapping of cysteines in mammalian glutaredoxin reveal their differential oxidation susceptibility

Covalent Modifiers

Corteselli, E.M., Sharafi, M., Hondal, R. et al. Nat Commun 14 , 4550 (2023). [link] Protein-S-glutathionylation is a post-translational modification involving the conjugation of glutathione to protein thiols, which can modulate the activity and structure of key cellular proteins. Glutaredoxins (GLRX) are oxidoreductases that regulate this process by performing deglutathionylation.

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Oldest known species of swimming jellyfish identified

Science Daily: Pharmacology News

Royal Ontario Museum announces the oldest swimming jellyfish in the fossil record with the newly named Burgessomedusa phasmiformis. This 505-million-year-old swimming jellyfish from the Burgess Shale highlights diversity in the Cambrian ecosystem.

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Researchers Explore New Nonaddictive Means of Fighting Pain

Drugs.com

THURSDAY, Aug. 3, 2023 -- New research shows that an experimental drug fine-tuned to a specific pain pathway can ease post-surgery aches, a finding that may eventually offer an alternative to highly addictive opioids. The pill, known for now as.

Research 246
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BridgeBio explores path forward for muscular disease drug

BioPharma Drive: Drug Pricing

According to the company, FDA officials have signaled openness to using a surrogate endpoint for assessing accelerated approval of a treatment for limb-girdle muscular dystrophy.

Disease 246
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Understand Clinical Observations [Metabolism, Transport, and Pharmacogenetics]

ASPET

The natural product goldenseal is a clinical inhibitor of CYP3A activity, as evidenced by a 40-60% increase in midazolam AUC after coadministration with goldenseal. The predominant goldenseal alkaloids berberine and (-)-β-hydrastine were previously identified as time-dependent CYP3A inhibitors using human liver microsomes. Whether these alkaloids contribute to the clinical interaction, as well as the primary anatomical site (hepatic vs. intestinal) and mode of CYP3A inhibition (reversible v

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Sweet smell of success: Simple fragrance method produces major memory boost

Science Daily: Pharmacology News

When a fragrance wafted through the bedrooms of older adults for two hours every night for six months, memories skyrocketed. Participants in this study reaped a 226% increase in cognitive capacity compared to the control group. The researchers say the finding transforms the long-known tie between smell and memory into an easy, non-invasive technique for strengthening memory and potentially deterring dementia.

Research 190
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AI-Assisted Mammograms Could Be a Big Advance: Study

Drugs.com

WEDNESDAY, Aug. 2, 2023 -- Artificial intelligence (AI) programs can safely be used to help radiologists review mammogram images and detect breast cancers, early results from an ongoing clinical trial show. A single radiologist aided by AI wound up.

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Regeneron gets ‘clarity’ in plan to defend top-selling eye drug, but is set back elsewhere

BioPharma Drive: Drug Pricing

The surprise rejection of a high-dose form of Eylea could be resolved earlier than anticipated. But some of the company’s pipeline projects have stumbled.

Drugs 244
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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The Plasma Membrane Monoamine Transporter (PMAT) is Highly Expressed in Neuroblastoma and Functions as an mIBG Transporter [Metabolism, Transport, and Pharmacogenetics]

ASPET

Neuroblastoma (NB) is a pediatric cancer with low survival rates in high-risk patients. 131 I-mIBG has emerged as a promising therapy for high-risk NB and kills tumor cells by radiation. Consequently, 131 I-mIBG tumor uptake and retention are major determinants for its therapeutic efficacy. mIBG enters NB cells through the norepinephrine transporter (NET), and accumulates in mitochondria through unknown mechanisms.

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Half the population to have a mental health disorder by 75

Science Daily: Pharmacology News

Scientists analyzed data from more than 150,000 adults across 29 countries between 2001 and 2022 with results demonstrating the high prevalence of mental health disorders, with 50 per cent of the population developing at least one disorder by the age of 75.

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Amid Shortages, Federal Agencies Ask Drugmakers to Boost Output of ADHD Meds

Drugs.com

WEDNESDAY, Aug. 2, 2023 -- While demand for prescription stimulants is surging, a shortage of the drugs persists, so federal officials have stepped in and asked drug companies to ramp up production of the medications. Officials from both the U.S.

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RSV antibody from Sanofi, AstraZeneca backed by CDC for use in infants

BioPharma Drive: Drug Pricing

The treatment, which won FDA approval in July, is expected to be available by the start of the typical RSV season this fall.

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Mesna Improves Outcomes of Sulfur Mustard Inhalation Toxicity in an Acute Rat Model [Drug Discovery and Translational Medicine]

ASPET

Inhalation of high levels of sulfur mustard (SM), a potent vesicating and alkylating agent used in chemical warfare, results in acutely lethal pulmonary damage. Sodium 2-mercaptoethane sulfonate (mesna) is an organosulfur compound that is currently FDA-approved for decreasing the toxicity of mustard-derived chemotherapeutic alkylating agents like ifosfamide and cyclophosphamide.

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New study links brain waves directly to memory

Science Daily: Pharmacology News

Simply remembering events can trigger brain rhythms, even more so than when people are experiencing the actual event, says a new study. The findings could lay foundations for cognitive impairment therapy and help improve memory.

Therapies 190
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Psilocybin May Help Some Who Battle Anorexia

Drugs.com

TUESDAY, Aug. 1, 2023 -- One dose of the hallucinogenic ingredient in "magic mushrooms" may help some people with anorexia move past their preoccupation with body image, an early study suggests. The study, of just 10 women with anorexia, tested the.

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Novartis sickle cell drug’s approval formally revoked by EU regulators

BioPharma Drive: Drug Pricing

The company said it would withdraw the drug, Adakveo, from the EU market after the European Commission endorsed an earlier EMA recommendation.