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Researchers use machine learning to engineer 'bespoke enzymes' for gene editing

Science Daily: Pharmacology News

A new paper showcases the power of scalable protein engineering combined with machine learning to boost progress in the field of gene and cell therapy. Genome editing has advanced at a rapid pace with promising results for treating genetic conditions -- but there is always room for improvement.

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Scientists engineer CRISPR enzymes that evade the immune system

Broad Institute

Scientists engineer CRISPR enzymes that evade the immune system By Allessandra DiCorato January 9, 2025 Breadcrumb Home Scientists engineer CRISPR enzymes that evade the immune system The new genome-editing tools could lead to safer, more efficient gene therapies. Lisa Yang Center for Autism Research at MIT, and the K.

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Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30

Covalent Modifiers

Here we report the crystal structure of human USP30 in complex with a specific inhibitor, enabled by chimeric protein engineering. Collectively, our work establishes a generalizable chimeric protein-engineering strategy to aid deubiquitinase crystallization and enables structure-based drug design with relevance to neurodegeneration.

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Engineers make tunable, shape-changing metamaterial inspired by vintage toys

Science Daily: Pharmacology News

Now, a team of engineers has created a new class of tunable dynamic material that mimics the inner workings of push puppets, with applications for soft robotics, reconfigurable architectures and space engineering.

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Scientists cut harmful pollution from hydrogen engines

Science Daily: Pharmacology News

Scientists have discovered a low-cost method to significantly reduce this pollution from hydrogen internal combustion engines by improving the efficiency of their catalytic converters.

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Engineers design soft and flexible 'skeletons' for muscle-powered robots

Science Daily: Pharmacology News

Engineers designed modular, spring-like devices to maximize the work of live muscle fibers so they can be harnessed to power biohybrid robots.

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Team engineers new enzyme to produce synthetic genetic material

Science Daily: Pharmacology News

A research team describes how they engineered an efficient new enzyme that can produce a synthetic genetic material called threose nucleic acid.