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a leading global provider of immuno-oncology imaging agents, today announced it has signed a new multi-year, non-exclusive license with Pfizer Inc. ImaginAb will receive license fees and payments for manufacturing and other support. LOS ANGELES , Jan. 7, 2021 /PRNewswire/ — ImaginAb Inc. , No other terms were disclosed.
Merck will select cancer targets and harness Janux’s proprietary Tumor Activated T Cell Engager (TRACTr) technology to engineer novel, T cell engager drug candidates. Janux technology can be applied to immunotherapies that target all three stages of an anti-tumor immuneresponse.
Anderson Professor of Chemical and Biomolecular Engineering, and his colleagues, are reporting in iScience the event of an intranasal subunit vaccine that gives durable local immunity against inhaled pathogens. A fundamental limitation of intramuscular vaccines is that they’re not designed to elicit mucosal immunity.
These include engineering the cells to express cytokines that promote their maturation and/or differentiation, and engineering drug-resistant γδ T cells that can be combined with chemotherapies, which stress cancer cells but would otherwise also deplete the T-cell population. References Fichtner A, Ravens S, Prinz I.
One consideration in using syngeneic models is that some drug candidates can cause a negative immuneresponse not seen in humans. Taconic Biosciences is a fully-licensed, global leader in genetically engineered rodent models and services.
iosBio , a UK-based biotechnology company, has announced an exclusive worldwide licensing agreement with ImmunityBio , a clinical-stage immunotherapy company, for rights to use iosBio’s OraPro vaccine platform technology to test the oral administration of ImmunityBio’s vaccine candidate.
We believe our allogenic CAR-T platform is significantly stronger with chPD1 target licensed from Longwood University. Chimeric PD-1 T-cells also release cytokines to further initiate immuneresponses to eradicate the tumor cells. Amorette Barber of Longwood University will be heading up our chPD1 program.
(Nasdaq: TNXP) (Tonix or the Company), a clinical-stage biopharmaceutical company, today announced that the first participant was enrolled in the observational PRECISION study (TNX-C002), to examine the immuneresponses to COVID-19 in healthy volunteers who have recovered from COVID-19 or were asymptomatic. 1 Noyce RS, et al.
He showed that these synthetic CAR T cells could launch an immuneresponse when they encountered the corresponding tumor protein, called CD19. Our initial work with engineered T cells in HIV patients revealed that these cells could persist in the body far longer than anticipated, said June, who is the Richard W.
Published June 27, 2025 Ned Pagliarulo Lead Editor post share post print email license Bristol Myers Squibb sells two CAR-T cell therapies for cancer. These medicines are made from a patient’s own immune cells, extracted from the body and engineered in a lab to hunt down specific proteins found on the surface of malignant clones.
a San Diego-based biotechnology company with an array of technology platforms for antibody discovery and optimization, and novel NK and T cell engager generation, today announced licensing of a panel of its anti-SARS-CoV-2 antibody clones to IGM Biosciences for COVID-19 therapy development.
Phage-based products have been licensed for use as antibacterial agents in the sanitation , food production , and animal health industries. Crucially, it could also make them easier to license as therapeutic agents. The resulting data are fed into an analytical engine that runs millions of simulations. aeruginosa, S. pneumoniae.
In the context of preclinical research, using healthy cells to study disease-specific mechanisms, cell-cell interactions, and immuneresponses can result in faulty data, missed therapeutic targets, and unanticipated immuneresponses.
The company announced donanemab received Breakthrough Therapy designation for treatment of Alzheimer’s disease and its intention to submit a biologics license application (BLA) for donanemab under the accelerated approval pathway later this year based on data from TRAILBLAZER-ALZ. Loxo Oncology at Lilly and Kumquat Biosciences Inc.
But for a recent paper out of Nanjing, China, researchers engineered another enzyme and showed that, when mixed with FAST-PETase, the two worked together to break down plastic twice as fast as the Texas enzyme alone. a lower risk of immuneresponses. They don’t always break down PET into a form that is easily recycled.
But for a recent paper out of Nanjing, China, researchers engineered another enzyme and showed that, when mixed with FAST-PETase, the two worked together to break down plastic twice as fast as the Texas enzyme alone. a lower risk of immuneresponses. They don’t always break down PET into a form that is easily recycled.
At best, the corporations with the best models released weak versions to the public under non-commercial licenses. The new viruses could shuffle surface antigens after encountering an immuneresponse, rapidly adopt new conformations to fit through tight cellular junctions, and self-replicate at safe background levels for years on end.
platform and its patented large-capacity VV cop TK-RR- oncolytic virus, which has been engineered to encode both a Treg-depleting human recombinant anti-CTLA4 antibody generated by BioInvent’s proprietary n-CoDeR ® /F.I.R.S.T BT-001 is a best-in-class oncolytic Vaccinia virus. It has been generated using Transgene’s Invir.IO
This is particularly beneficial for those who need chronic transfusions and are therefore at risk of developing an immuneresponse to transfusion products from other people, or for those with religious beliefs, like Jehovah’s Witnesses, whose faith prohibits blood transfusions from another person.
With the depth and breadth of our current portfolio, the tremendous potential of our pipeline and scientific engine, and the power of our culture of innovation, we are poised to continue delivering meaningful value to patients by addressing some of the world’s most difficult health challenges.”.
Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. Skin microbes can trigger strong immuneresponses. In other words: Brush some engineered bacteria on the skin, and they activate the immune system to go fight a tumor. Metabolic Engineering. Wichmann J.
Both vaccine candidates incorporate Novavax’ proprietary saponin-based Matrix-M adjuvant in order to enhance the immuneresponse and stimulate high levels of neutralizing antibodies.
Both vaccine candidates incorporate Novavax’ proprietary saponin-based Matrix-M adjuvant in order to enhance the immuneresponse and stimulate high levels of neutralizing antibodies.
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