Codon

JUNE 5, 2025

pyogenes protein — whose compactness makes them far easier to package into viral vectors and deliver into the human body. Researchers have engineered more specific enzymes — possessing drastically reduced off-target effects — by altering either the structure of the Cas9 protein itself or its gRNA. Join Asimov Press.

DNA 81

DNA RNA Clinical Trials Engineering 81

Codon

JANUARY 5, 2025

Some field strategists — such as Salvador Luria, in the case of molecular biology — have a warm personality that draws individuals into a field. A package containing 100 cc. But that was not the case with Cohn, who had a penchant for success despite his interpersonal quirks. cans of serum albumin.

Laboratories 105

Laboratories Science Production Research 105

Codon

NOVEMBER 1, 2024

I’ve chosen these two because I think they are the linchpin by which we’ll be able to build broadly useful AI models for cell and molecular biology. But looking ahead to the second bottleneck, what does it mean to say that biology is “complex”?

DNA 132

DNA RNA Molecular Biology Laboratories 132

Codon

APRIL 2, 2024

A gene encoding green fluorescent protein was placed alongside one of the three promoters, and as the engineered cells cycled from one gene to the next, they blinked between green—dark—green—dark. These papers became the standard-bearers for a new scientific field: synthetic biology.

RNA 57

RNA Engineering Molecular Biology Synthetic Chemistry 57

Drug Target Review

MAY 22, 2024

Secondly, circRNAs can be engineered for more efficient protein expression by carefully selecting and optimising the IRES element, a sequence motif derived from viruses and used to initiate cap-independent translation from circRNA. We are now running follow-up experiments to track the advantage long-term.

Therapies 59

Therapies RNA Protein Expression DNA 59

Codon

FEBRUARY 13, 2024

The resulting data are fed into an analytical engine that runs millions of simulations. ” A Global View Even as advances in computing and molecular biology usher in the era of a new, high-tech “phage therapy 2.0”, Locus has products in development targeting four common sources of bacterial infections: E.

Therapies 137

Therapies Virus DNA Clinical Trials 137

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. Another paper recently reported an engineered Cas protein that is “up to 11.3-fold

Therapies 52

Therapies RNA DNA Engineering 52