Engineering Molecular Biology Regulations 
Codon
JUNE 5, 2025
Researchers have engineered more specific enzymes — possessing drastically reduced off-target effects — by altering either the structure of the Cas9 protein itself or its gRNA. Researchers have also created a broad spectrum of engineered Cas9 proteins with improved functionality, especially increased precision and specificity.
Codon
NOVEMBER 1, 2024
I’ve chosen these two because I think they are the linchpin by which we’ll be able to build broadly useful AI models for cell and molecular biology. But looking ahead to the second bottleneck, what does it mean to say that biology is “complex”?
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Codon
JUNE 12, 2025
In many plants, such as a cob of corn, we have engineered the functionality of that plant over many years. ” It's not a great place to invest given the capital, entrenched interests, regulations, etc. We can’t engineer that. Five years later, he gave the field the name it now goes by: molecular biology.
The Pharma Data
JANUARY 19, 2021
But altering the tracr-L with genetic engineering to make it function more like a guide RNA increased CRISPR-Cas9 cuts. The authors suggest natural tracr-L regulates autoimmunity. In bacteria with unaltered tracr-L, levels of CRISPR-related genes were low. And removing tracr-L altogether greatly increased CRISPR-Cas9 expression.
Drug Target Review
FEBRUARY 28, 2024
These include engineering the cells to express cytokines that promote their maturation and/or differentiation, and engineering drug-resistant γδ T cells that can be combined with chemotherapies, which stress cancer cells but would otherwise also deplete the T-cell population. Regulation of cutaneous malignancy by gammadelta T cells.
Broad Institute
NOVEMBER 17, 2023
Her research seeks to understand the mechanisms that regulate the disappearance of synapses — junctions where nerves communicate with each other — by focusing on how immune-related molecules mediate this process. His lab studies gene delivery solutions with the aim of uncovering new avenues for treating psychiatric disorders.
The Pharma Data
JANUARY 4, 2021
Longwood has a robust research department with 7 post doctorates conducting research in molecular biology, microbiology, genomics, cancer biology, and immunology and publishing over 75 publications in different scientific journals in the past 5 years. Barber also serves on Kiromic’s Scientific Advisory Board.
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