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A Visual Guide to Genome Editors

Codon

The core of the CRISPR immune response is a guide RNA (gRNA) that binds to a CRISPR-associated (Cas) protein. Traditional approaches to this problem involve the use of viral vectors , which run the risk of triggering immune responses in patients. Collectively, these repeat-protospacer regions are known as CRISPR arrays.

DNA
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Scientists discover network of cells and genes involved in Crohn’s disease complication

Broad Institute

Appearing today in Nature Genetics , the work was led by senior authors Ramnik Xavier and Christopher Smillie , associate member at the Broad and an assistant professor at Harvard Medical School. The team thinks these cells and the collagen they produce could be responsible for making the stricture that contracts intestinal tissue.

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Broad Discovery Series: Introducing the immune system, and expanding its cancer-fighting potential

Broad Institute

Lloyd Bod is an associate member of Broad, a principal investigator in the Krantz Family Center for Cancer Research at Massachusetts General Hospital, and an assistant professor of medicine at Harvard Medical School.

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Targeting the immunotherapy potential of cytokines IL-12 and IL-18 with new advancements in protein engineering

Drug Target Review

Natural killer (NK) cells are another immune cell type that, as the name suggests, also have potent cell-killing activity, and have a well-known role in the anti-tumour immune response. In the context of a tumour microenvironment, Tregs are often present in high numbers, preventing an effective immune response to the tumour.

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Researchers decipher how a gut bacterium influences immunity

Broad Institute

Researchers decipher how a gut bacterium influences immunity By Corie Lok July 26, 2022 Breadcrumb Home News Researchers decipher how a gut bacterium influences immunity Study finds a molecule made by the bacterium that helps moderate immune responses. Adapted from a press release issued by Harvard Medical School.

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Laurie Glimcher

Broad Institute

She is also director of the Dana-Farber/Harvard Cancer Center and the Richard and Susan Smith Professor of Medicine at Harvard Medical School. Previously, she was the Stephen and Suzanne Weiss Dean and Professor of Medicine of Weill Cornell Medicine and provost for medical affairs of Cornell University. Glimcher, M.D.,

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Cancer immunotherapy candidate provokes powerful dual response in cancer and immune cells

Broad Institute

This is an unprecedented opportunity to evaluate how immune responses work,” said Robert Manguso , who is co-senior author on the study, an associate member at the Broad, and an assistant professor at the Massachusetts General Hospital Center for Cancer Research and Harvard Medical School.