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The plant virus that trains your immune system to kill cancer

Science Daily: Pharmacology News

A virus from humble black-eyed peas is showing extraordinary promise in the fight against cancer. Unlike other plant viruses, the cowpea mosaic virus (CPMV) can awaken the human immune system and transform it into a cancer-fighting powerhouse, without infecting human cells.

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This tiny lung-on-a-chip could predict—and fight—the next pandemic

Science Daily: Pharmacology News

Powered by isogenic induced pluripotent stem cells (iPSCs), the system offers a high-fidelity way to model personalized immune responses and test drug effectiveness. This innovation opens the door to precision medicine, deeper understanding of emerging viruses, and even modeling of other organs in the future.

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The future of CNS drug development: signs of real progress

Drug Target Review

Due to off-target effects, tissue accumulation and immune responses, ASOs face significant challenges, especially for preclinical safety assessments. Viral vectors use a virus’s blueprint to deliver genetic material into cells. However, ASOs cannot cross blood-CNS barriers so are often delivered intrathecally.

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A Visual Guide to Genome Editors

Codon

The core of the CRISPR immune response is a guide RNA (gRNA) that binds to a CRISPR-associated (Cas) protein. If the same virus invades the cell a second time, the gRNA’s spacer sequence will bind to the matching viral DNA sequence, then be cut by the Cas protein.

DNA
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Two HIV vaccine trials show proof of concept for pathway to broadly neutralizing antibodies

Science Daily: Pharmacology News

A decades-long scientific challenge in HIV vaccine development has been finding a way to train the immune system to produce antibodies that can target many variants of the virus. Traditional approaches haven't worked -- largely because HIV mutates rapidly and hides key parts of itself from the immune system.

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Researchers design gene therapy that can effectively target glioblastoma

Science Daily: Pharmacology News

Immunotherapies, which mobilize the body's immune defenses against a cancer, have not been effective for GBM, in part because the tumor's surrounding environment is largely impenetrable to assaults from the body's immune system.

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Sanofi to acquire vaccine biotech in billion-dollar deal

BioPharma Drive: Drug Pricing

Through the deal, Sanofi will gain a combination shot now in clinical testing for protection against respiratory syncytial virus and human metapneumovirus, or hMPV. This “ molecular clamp ” platform is designed to elicit strong immune responses against respiratory diseases, while permitting simpler and faster production and distribution.