Drug Target Review

DECEMBER 7, 2023

Phage have been of interest to scientists as tools to understand fundamental molecular biology, as vectors of horizontal gene transfer and drivers of bacterial evolution, as sources of diagnostic and genetic tools, and as novel therapeutic agents. He continued: “CBASS cyclases look a lot like cGAS, so they have to be sensing something.

RNA 59

RNA Immune Response DNA Molecular Biology 59

Alta Sciences

MARCH 1, 2024

PJ: At Altasciences, we have a range of leading-edge platforms that include ligand binding assays (LBA), NAb, TAb, flow cytometry, and ELISpot, as well as on-site molecular biology instrumentation such as Bio-Rad’s ddPCR system, the NanoDropTM One spectrophotometer, and dedicated polymerase chain reaction (PCR) chambers.

Therapies 52

Therapies Laboratories Molecular Biology RNA 52

Codon

JULY 10, 2024

But in the 1950s, at the dawn of molecular biology, scientists gained a new appreciation for it after searching for organisms that were easy to work with and quick to grow. 1 This singular organism has become the de facto microbe for molecular biology. Lee showed me around the laboratories on a clear day in April.

Laboratories 92

Laboratories DNA Molecular Biology Engineering 92

Codon

JUNE 25, 2024

So-called primary cells, harvested from living tissues and cultured in the laboratory, can take weeks to grow and spread across a culture flask, hampered partly by their large genomes, which take time to copy. Proteins are colored blue and RNA molecules are colored orange and yellow. The large and small ribosome subunits.

DNA 93

DNA RNA Laboratories Research 93

Codon

APRIL 2, 2024

But in those early years, everything in the laboratory was so slow and difficult. I was reading a lot of molecular biology papers about different systems, especially circadian clocks, and also a book called Biological Feedback , by Thomas and D’Ari, that sketched out really simple models for different kinds of feedback circuits.

RNA 57

RNA Engineering Molecular Biology Synthetic Chemistry 57

The Pharma Data

FEBRUARY 25, 2022

. “The SARS-CoV-2 vaccines target the spike protein, but this protein is under strong selection pressure and, as we have seen with Omicron, can undergo significant mutations,” said Joyce Jose, assistant professor of biochemistry and molecular biology, Penn State. 25) in the journal Communications Biology.

FDA Approval 52

FDA Approval Molecular Biology FDA Virus 52

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. William Studier developed the T7 expression technology at Brookhaven National Laboratory. Credit: Brookhaven National Laboratory.

RNA 84

RNA Production Molecular Biology Laboratories 84

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. How do transcription factors couple up with the correct RNA molecule?

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

.” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” ” This was a series of tweets in which I told brief stories behind seminal papers, mostly in molecular biology and biophysics. How do transcription factors couple up with the correct RNA molecule?

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JUNE 26, 2023

This reminds me of the Chemputer , “an autonomous compiler and robotic laboratory platform to synthesize organic compounds on the basis of standardized methods descriptions,” that was reported back in 2019. A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. Paper by Sha G. in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

This reminds me of the Chemputer , “an autonomous compiler and robotic laboratory platform to synthesize organic compounds on the basis of standardized methods descriptions,” that was reported back in 2019. A T4 phage can hold 171,000 bases of DNA or other molecules, including proteins and RNA. Paper by Sha G. in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. It is the untouchable foundation of molecular biology. This is simple.

RNA 75

RNA DNA Engineering Laboratories 75

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. It is the untouchable foundation of molecular biology. This is simple.

RNA 52

RNA DNA Engineering Laboratories 52

Broad Institute

JANUARY 30, 2024

He spent many school breaks at Argonne National Laboratory where his parents both worked as scientists. His advisor marched him down to the office of a new faculty member, Tobin Sosnick, who is now chair of the Department of Biochemistry and Molecular Biology at the University of Chicago.

Hospitals 137

Hospitals Virus Medical Schools Science 137

Broad Institute

APRIL 3, 2025

Our work converts imaging into molecular biology just a reaction in a test tube, said Fei Chen , who is a senior author on the study, a core institute member at the Broad, and an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University. Each colored dot represents a different cell type.

DNA 119

DNA RNA Molecular Biology Laboratories 119

Broad Institute

JANUARY 7, 2025

From her first biology course in high school, Rehm loved the logic of genetics: the clear trajectory from a simple code of DNA to RNA to proteins and how disrupting that process could lead to disease. A common language As Rehm was building the Laboratory for Molecular Medicine, she put her community-building skills to work.

Disease 121

Disease Science Laboratories Medical Schools 121

Codon

MAY 29, 2025

This deadly structure allows it to kill its victims by preventing their cells from making messenger RNA (mRNA) through inhibition of the enzyme RNA Polymerase II. The ADC approach allows healthy cells to avoid the deadly effects suffered by the cancer cells as their RNA polymerase II enzymes are shut down. Credit: Nigel Voaden.

Drugs 106

Drugs DNA RNA Laboratories 106