Drug Target Review

JULY 1, 2024

SRP-001 targets the central nervous system (CNS) by producing N-arachidonoylaminophenol (AM404) in the midbrain’s periaqueductal grey (PAG) region, crucial for pain sensation and regulation. The single-cell transcriptomic analysis in the Sci Reports paper 1 provides insights into SRP-001’s pain-relief mechanisms.

Treatment 59

Treatment Clinical Trials Therapies Molecular Biology 59

The Pharma Data

OCTOBER 18, 2020

NASDAQ:CDXC) today highlighted a new study published in The European Molecular Biology Organization Journal looking at the effect of nicotinamide riboside (NR) on maintaining telomeres, the protective regions at the end of DNA strands. 19, 2020 10:32 UTC. LOS ANGELES–( BUSINESS WIRE )– ChromaDex Corp.

DNA 52

DNA Molecular Biology Disease Trials 52

Drug Target Review

OCTOBER 25, 2024

Progress in molecular biology and translational science. Α-synuclein in the pathophysiology of alzheimer’s disease – molecular neurodegeneration. FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in alzheimer’s disease – acta neuropathologica.

Disease 59

Disease Clinical Trials Therapies Science 59

DrugBaron

NOVEMBER 22, 2022

Most proteomics methodology used today provides an enumeration of the major proteins present with poorly validated attempts at quantitation and even less focus on the subtly different variants of each “protein” present in the mixture.

Bioinformatics 100

Bioinformatics Regulations Molecular Biology Engineering 100

Codon

FEBRUARY 13, 2024

Regulators traditionally want to see a single, stable, well-characterized drug before giving the green light for it to be tested in a clinical trial, not dozens of different viruses; let alone ones that are best found in unappealing places like sewage , hospital waste, or bird poop.

Therapies 137

Therapies Virus DNA Clinical Trials 137

Codon

JUNE 25, 2024

Sometimes cells don’t take up the DNA, or unforeseen issues with the modified sequence arise—such as off-target mutations, unexpected protein modifications, or disruptions to gene regulation—that send us back to the drawing board. These setbacks can extend the timeline from days to weeks. The resulting strain of V.

DNA 93

DNA RNA Laboratories Research 93

Codon

APRIL 2, 2024

I was reading a lot of molecular biology papers about different systems, especially circadian clocks, and also a book called Biological Feedback , by Thomas and D’Ari, that sketched out really simple models for different kinds of feedback circuits. Slides from a lab talk presented in Heidelberg, Germany in 1998.

RNA 57

RNA Engineering Molecular Biology Synthetic Chemistry 57

BMG Labtech

MARCH 8, 2023

In fact, metabolism should not be considered as a self-regulating entity that is independent of other biological pathways. For instance, intermediates of the TCA cycle are present in all known organisms from unicellular bacteria to complex and large multicellular organisms like elephants. 7 (3): 276–82. doi:10.1038/sj.embor.7400646.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

JUNE 26, 2023

The first presents a new method to count mRNAs and proteins, in individual plant cells, at the same time. Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history. plasmidsaurus @arjunrajlab (Regulation in biology is incredible. Paper by Sha G.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

The first presents a new method to count mRNAs and proteins, in individual plant cells, at the same time. Future Nobel Laureate, Paul Berg, narrated the video, which quickly became a cult classic moment in molecular biology history. plasmidsaurus @arjunrajlab (Regulation in biology is incredible. Paper by Sha G.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JULY 27, 2023

“The first printout of the human genome to be presented as a series of books, displayed in the 'Medicine Now' room at the Wellcome Collection, London. ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” It fills up an entire bookcase ! You can read all of them here.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

“The first printout of the human genome to be presented as a series of books, displayed in the 'Medicine Now' room at the Wellcome Collection, London. ” Wellcome Collection , London I wrapped up my series on “30 Days of Great Biology Papers.” It fills up an entire bookcase ! You can read all of them here.

Therapies 52

Therapies RNA DNA Engineering 52

The Pharma Data

DECEMBER 2, 2020

After discussing the application and any concerns, the FDA presents questions and the committee votes on each question. Regulators must “move as quickly as possible, but not so quickly as to erode confidence,” she continued. Although the Agency has a staff of about 17,000, “It can’t have experts for every single disease,” Durbin said.

Vaccine 52

Vaccine FDA Molecular Biology Licensing 52

Codon

AUGUST 10, 2023

Link Gene Expression & Regulation →Genetic regulatory mechanisms in the synthesis of proteins , by Jacob F. & Journal of Molecular Biology (1961). Gene Expression and Regulation. Nature Reviews Molecular Cell Biology (2008). Link The Systems Biology Graphical Notation , by Le Novère N.

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Link Gene Expression & Regulation →Genetic regulatory mechanisms in the synthesis of proteins , by Jacob F. & Journal of Molecular Biology (1961). Gene Expression and Regulation. Nature Reviews Molecular Cell Biology (2008). Link The Systems Biology Graphical Notation , by Le Novère N.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Elrig

MAY 7, 2025

Taking place at the ACC in Liverpool, UK from 2122 October, the conference will feature presentations from Professor Heather Pinkett (Northwestern University) and Dr Dafydd Owen (Pfizer Medicine Design). Prof Pinkett will present Targeting ABC Transporters: Structural Prediction and Computational Strategies Against AMR on the first day.

Drugs 59

Drugs Molecular Biology Science International 59

BMG Labtech

FEBRUARY 24, 2025

Protein nitration is one example that takes place on tyrosine residues which can have important consequences for the regulation of biological processes. Detecting nitrated tyrosine residues in these assays presents challenges due to the complexities in accurately quantifying and identifying these specific modifications in proteins.

Small Molecule 52

Small Molecule Disease Licensing Licensing 52

Codon

DECEMBER 1, 2024

By Matthew Cobb The Central Dogma is a linchpin for understanding how cells work, and yet it is one of the most widely misunderstood concepts in molecular biology. That is pretty much exactly what happens in many microbes; gene regulation responds to environmental stimuli.

RNA 134

RNA DNA Molecular Biology Virus 134