BioPharma Drive: Drug Pricing
JUNE 10, 2025
The abrupt termination of the 17 panelists guiding the CDC’s vaccine recommendations could yield a new committee more aligned with Robert F. Kennedy Jr.’s skeptical views, analysts warned.
Drugs.com
JUNE 10, 2025
TUESDAY, June 10, 2025 — U.S. Health and Human Services Secretary Robert F. Kennedy Jr. has removed all 17 members of the expert panel that makes U.S. vaccine recommendations. Kennedy made the surprise announcement in an opinion piece.
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Science Daily: Pharmacology News
JUNE 10, 2025
Acetaminophen may be doing more than just dulling pain in your brain it could be stopping it before it even starts. Scientists at Hebrew University have discovered that a metabolite of the drug, AM404, blocks pain signals right at their source by shutting down specific sodium channels in pain-sensing nerves. This radically shifts our understanding of how this common medication works and opens a door to new, more targeted painkillers that might eliminate side effects like numbness or weakness.
Covalent Modifiers
JUNE 9, 2025
Charlotte M. Zammit, Cory M. Nadel, Ying Lin, Sajjan Koirala, Elnaz Ahani, Patrick Ryan Potts, and Daniel K. Nomura Journal of the American Chemical Society 2025 DOI: 10.1021/jacs.5c02801 Androgen-independent prostate cancers, correlated with heightened aggressiveness and poor prognosis, are caused by mutations or deletions in the androgen receptor (AR) or the expression of truncated variants of AR that are constitutively activated.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
BioPharma Drive: Drug Pricing
JUNE 11, 2025
Insmed shares rocketed on results for a pulmonary arterial hypertension drug that exceeded Wall Street expectations. Elsewhere, Recursion is laying off 20% of its workforce and Gilead halted several HIV studies.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
JUNE 10, 2025
Scientists in Japan have discovered that a natural compound found in a type of ginger called kencur can throw cancer cells into disarray by disrupting how they generate energy. While healthy cells use oxygen to make energy efficiently, cancer cells often rely on a backup method. This ginger-derived molecule doesn t attack that method directly it shuts down the cells' fat-making machinery instead, which surprisingly causes the cells to ramp up their backup system even more.
Chemical Biology and Drug Design
JUNE 9, 2025
A series of small molecule PD-L1 inhibitors was discovered via optimization of the solvent-interaction region. GJ19 showed the most potent anti-PD-L1 effects with an IC 50 of 32.06 nM. GJ19 (i.p., 15 mg/kg) effectively suppressed tumor growth with a TGI of 56.8% in a B16-F10 melanoma mouse model. ABSTRACT Despite extensive research, the topic of anti-PD-L1 small-molecule inhibitors remains elusive.
BioPharma Drive: Drug Pricing
JUNE 10, 2025
The startup, which has raised more than $2 billion in funding to aid young biotechs with drug production, said its “capacity expansion has outpaced industry demand.
Drugs.com
JUNE 11, 2025
WEDNESDAY, June 11, 2025 — The U.S. Food and Drug Administration (FDA) says it plans to use artificial intelligence (AI) to help speed the approval of new drugs and medical devices. That's one of several priorities federal officials detailed.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Science Daily: Pharmacology News
JUNE 8, 2025
Physicists have managed to simulate a strange quantum phenomenon where light appears to arise from empty space a concept that until now has only existed in theory. Using cutting-edge simulations, researchers modeled how powerful lasers interact with the so-called quantum vacuum, revealing how photons could bounce off each other and even generate new beams of light.
Broad Institute
JUNE 11, 2025
Broad Institute and Bayer extend their cardiovascular alliance By Leah Eisenstadt June 11, 2025 Breadcrumb Home Broad Institute and Bayer extend their cardiovascular alliance Partnership will continue with renewed focus on developing new cardiovascular therapies. By Broad Communications June 11, 2025 Related news Broad Institute and Bayer expand cardiovascular alliance Broad Institute of MIT and Harvard and Bayer Healthcare expand their partnership to develop therapies for cardiovascular disease
BioPharma Drive: Drug Pricing
JUNE 10, 2025
Five months after selling a cancer drug to Lilly for up to $2.5 billion, Scorpion has debuted a successor company led by its former management team to chase “previously inaccessible” drug targets.
Drugs.com
JUNE 9, 2025
MONDAY, June 9, 2025 — Prompt treatment with a drug combo can effectively manage chronic kidney disease in people with type 2 diabetes, a new clinical trial shows. Patients prescribed the combination of finerenone and empagliflozin.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Science Daily: Pharmacology News
JUNE 11, 2025
Sea cucumbers, long known for cleaning the ocean floor, may also harbor a powerful cancer-fighting secret. Scientists discovered a unique sugar in these marine creatures that can block Sulf-2, an enzyme that cancer cells use to spread. Unlike traditional medications, this compound doesn t cause dangerous blood clotting issues and offers a cleaner, potentially more sustainable way to develop carbohydrate-based drugs if scientists can find a way to synthesize it in the lab.
Chemical Biology and Drug Design
JUNE 10, 2025
In this study, the polysaccharides extracted from the residue of Corydalis yanhusuo were purified, its structure was characterized, and its antioxidant and anti-tumor activities in vitro were studied. The results showed that the purified polysaccharides of Corydalis yanhusuo have the potential as a natural antioxidant and anti-tumor agent. ABSTRACT This research extracted and purified polysaccharides from Corydalis yanhusuo residue.
BioPharma Drive: Drug Pricing
JUNE 9, 2025
The offer is the latest in a series of deals by Concentra, an entity controlled by Tang Capital Partners, to buy struggling biotechs and shut them down.
Drugs.com
JUNE 10, 2025
TUESDAY, June 10, 2025 — Blood tests can detect evidence of cancer three years earlier than the disease would otherwise be diagnosed, a new small-scale pilot study says. The test — called a multicancer early detection (MCED) test.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
JUNE 7, 2025
Humpback whales have been observed blowing bubble rings during friendly interactions with humans a behavior never before documented. This surprising display may be more than play; it could represent a sophisticated form of non-verbal communication. Scientists from the SETI Institute and UC Davis believe these interactions offer valuable insights into non-human intelligence, potentially helping refine our methods for detecting extraterrestrial life.
Drug Target Review
JUNE 9, 2025
The landscape of genetic medicine is undergoing a profound transformation, driven by innovative approaches that challenge the traditional, disease-specific paradigms. One company leading the charge in this revolution is Alltrna , whose pioneering work in engineered transfer RNA (tRNA) therapeutics is offering new hope for patients with rare genetic diseases.
BioPharma Drive: Drug Pricing
JUNE 9, 2025
It’s a truth that all clinical teams are aware of: risk mitigation is a core part of clinical trial success. But, what does that mean for your enrollment plan?
Drugs.com
JUNE 11, 2025
WEDNESDAY, June 11, 2025 — Women will flock to an HPV test they can perform at home in private, a new study indicates. Cervical cancer screening more than doubled when women were offered a mail-in self-collection test for human papillomavirus.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Chemical Biology and Drug Design
JUNE 9, 2025
Erianin suppresses ox-LDL-induced apoptosis and oxidative stress by regulating Nrf2 signaling in HUVECs. ABSTRACT Oxidized low-density lipoprotein (ox-LDL)-induced endothelial cell damage plays an important role in the pathogenesis of atherosclerosis (AS). This study aimed to investigate the ability of Erianin to protect human umbilical vein endothelial cells (HUVECs) against ox-LDL-induced oxidative stress and its underlying mechanisms.
addgene Blog
JUNE 10, 2025
These days, it hardly seems like we finish writing about one dual CRISPR-transposon system before another exciting new advance emerges! The programmability and targeting power of CRISPR combined with the large sequence capacity of transposons open whole new worlds to explore. The newest arrival on the scene is called evoCAST — an evolved CRISPR-associated transposase (CAST).
Science Daily: Pharmacology News
JUNE 11, 2025
A team of scientists has identified specialized neurons in the brain that store "meal memories" detailed recollections of when and what we eat. These engrams, found in the ventral hippocampus, help regulate eating behavior by communicating with hunger-related areas of the brain. When these memory traces are impaired due to distraction, brain injury, or memory disorders individuals are more likely to overeat because they can't recall recent meals.
Drugs.com
JUNE 10, 2025
TUESDAY, June 10, 2025 -- The U.S. Food and Drug Administration has approved the Sonu Band, an artificial intelligence-enabled, wearable medical device for at-home treatment of moderate-to-severe nasal congestion in pediatric patients aged 12 and.
BioPharma Drive: Drug Pricing
JUNE 9, 2025
A "sub-study" of a late-stage clinical trial found the drug, obicetrapib, significantly reduced levels of a certain type of tau protein linked to Alzheimer's development.
Chemical Biology and Drug Design
JUNE 9, 2025
The overall mechanism diagram of ferulic acid delaying renal interstitial fibrosis and inhibiting incomplete EMT of TECs by regulating HIF-1α. ABSTRACT Ferulic acid (FA), a natural phenolic compound, shows potential therapeutic effects on renal interstitial fibrosis, although its antifibrotic mechanism remains unclear. This study investigated the molecular mechanisms of FA by focusing on epithelial-mesenchymal transition (EMT) and related signaling pathways.
Science Daily: Pharmacology News
JUNE 8, 2025
Beneath Earth s surface, nearly 3,000 kilometers down, lies a mysterious layer where seismic waves speed up inexplicably. For decades, scientists puzzled over this D" layer. Now, groundbreaking experiments by ETH Zurich have finally revealed that solid rock flows at extreme depths, acting like liquid in motion. This horizontal mantle flow aligns mineral crystals called post-perovskite in a single direction, explaining the seismic behavior.
Drugs.com
JUNE 11, 2025
WEDNESDAY, June 11, 2025 — Real-world results for blockbuster weight-loss meds like Ozempic, Wegovy and Zepbound aren’t as impressive as those promised by the drugs’ clinical trials, a new study says. People taking such GLP-1.
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