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Psilocybin, the active ingredient in magic mushrooms, might just revolutionize how depression and anxiety are treated in cancer patients. In a groundbreaking trial, a single dose combined with therapy significantly reduced emotional suffering, and these effects often lasted over two years. As follow-up studies expand the research to multiple doses and larger samples, scientists are eyeing a possible new standard of care that merges psychedelics with psychological support.
TUESDAY, June 17, 2025 — Magic mushrooms might be key to quelling depression among people battling cancer.A single dose of psilocybin provided sustained reductions in depression and anxiety among cancer patients diagnosed with major depression, a.
THURSDAY, June 12, 2025 — A newly approved shot could soon help protect babies from respiratory syncytial virus (RSV), the top cause of hospitalization in U.S. infants. The U.S. Food and Drug Administration (FDA) has approved a monoclonal.
Valued at $1.25 billion, the deal expands BioNTech’s cancer drug portfolio and heads off royalty costs it could have owed CureVac in ongoing patent litigation.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Dhirendra K. Simanshu, Rui Xu, James P. Stice, Daniel J. Czyzyk, Siyu Feng, John-Paul Denson, Erin Riegler, Yue Yang, Cathy Zhang, Sofia Donovan, Brian P. Smith, Maria Abreu-Blanco, Ming Chen, Cindy Feng, Lijuan Fu, Dana Rabara, Lucy C Young, Marcin Dyba, Wupeng Yan, Ken Lin, Samar Ghorbanpoorvalukolaie, Erik K. Larsen, Wafa Malik, Allison Champagne, Katie Parker, Jin Hyun Ju, Stevan Jeknic, Dominic Esposito, David M.
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Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
A team at Kobe University has created a game-changing resource for autism research: 63 mouse embryonic stem cell lines, each carrying a genetic mutation strongly associated with the disorder. By pairing classic stem cell manipulation with precise CRISPR gene editing, they ve built a standardized platform that mirrors autism-linked genetic conditions in mice.
The deal centers around a medicine that could “shift the treatment paradigm for cardiovascular disease,” Lilly said, but also follows a yearslong in decline in Verve’s share price amid skepticism over the need for such a therapy.
Tibor Viktor Szalai, Vincenzo di Lorenzo, Nikolett Péczka, Levente M. Mihalovits, László Petri, Qirat F. Ashraf, Elvin D. de Araujo, Viktor Honti, Dávid Bajusz, and György M. Keserű ACS Medicinal Chemistry Letters 2025 16 (6), 991-997 DOI: 10.1021/acsmedchemlett.4c00622 The STAT family of transcription factors are important signaling hubs, with several of them, particularly STAT3, being emerging oncotargets already investigated in clinical trials.
Compare CDD Vault Curves vs GraphPad Prism for drug discovery data analysis. See which tool best fits your workflow for curve fitting and collaboration.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
MONDAY, June 16, 2025 — Texas has moved to fund research into ibogaine, a psychedelic drug that may help treat addiction, depression, and brain injuries. Gov. Greg Abbott signed a bill last week approving $50 million in state funds for.
Scientists have uncovered a previously unknown type of molecular motion inside DNA-based droplets: instead of spreading randomly, guest molecules advance in an organized wave. This surprising discovery opens the door to understanding how cells might organize internal processes without membranes. Using customizable DNA condensates as experimental models, the team showed how molecular waves emerge through precise DNA interactions.
The Danish drugmaker, which is grappling with a share decline and competition from Eli Lilly, unveiled planned trials of an obesity medication that works differently than its popular Wegovy.
Yu Tung Wong, Charles Bell, and Michael C. Willis Chem. Sci., 2025 DOI [link] Covalent inhibitor design is dominated by the use of electrophilic acrylamide warheads. One limitation of acrylamides is that there are limited opportunities to modify their electrophilicity, and hence reactivity, by simple structural changes. Here we show that vinyl sulfonimidamides are effective electophilic groups for reaction with both sulfur- and nitrogen-based biologically relevant nucleophiles.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
CDD Vault Update (June #2 2025): Bulk Register Sequences with Custom Monomers, Set X-axis Ranges in Plots, Filter AI Bioisostere Suggestions, Inventory Debits from ELN
MONDAY, June 16, 2025 — Kidney damage is common during a severe case of COVID-19, but vaccination appears to protect people against this life-threatening side effect, a new study says. Unvaccinated COVID patients with kidney damage severe enough to.
AI has helped astronomers crack open some of the universe s best-kept secrets by analyzing massive datasets about black holes. Using over 12 million simulations powered by high-throughput computing, scientists discovered that the Milky Way's central black hole is spinning at nearly maximum speed. Not only did this redefine theories about black hole behavior, but it also showed that the emission is driven by hot electrons in the disk, not jets, challenging long-standing models.
The agency cleared CSL’s hereditary angioedema drug days after “resource constraints” delayed a rival medicine. Elsewhere, Intellia revealed new data and Lilly beefed up an online service offering access to Zepbound.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Schematic of the mechanism of LYC in treating osteoporosis through the ESR1/PI3K/AKT pathway. LYC upregulates ESR1 expression and thus leads to the activation of the PI3K/AKT pathway, thereby inducing hBMSC osteogenic differentiation and attenuating osteoporosis development. ABSTRACT Osteoporosis is a widespread metabolic bone disorder. Lycopene (LYC), a potent antioxidant in tomatoes, has been shown to exhibit anti-osteoporosis effects.
FRIDAY, June 13, 2025 — A person’s microbiome – the bacteria naturally living in the mouth and gut – might contribute to Parkinson’s disease, a new study says.Specific changes in these bacteria are associated with cognitive decline in Parkinson’s, r.
When we focus, switch tasks, or face tough mental challenges, the brain starts to sync its internal rhythms, especially in the midfrontal region. A new study has found that smarter individuals show more precise and flexible coordination of slow theta waves during key decision-making moments. Using EEG recordings and cognitive testing, researchers discovered that it s not constant brainwave synchronization that matters most, but the brain s ability to dynamically adapt its rhythms like a well-tun
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Days after firing all 17 members of the CDC's Advisory Committee for Immunization Practices, the HHS Secretary named a small new committee that includes multiple vaccine critics.
In 2003, the completion of the Human Genome Project was celebrated as the start of a new era in medicine. However, even though genome sequencing can now be completed in a single day at a fraction of the original cost, and despite the exponential increase in data generation, nearly two decades later the clinical impact of genomics has been limited. The problem is not a lack of genetic insight; instead, biological processes operate on a level that goes far beyond genetic sequences.
By Ram Aiyar, CEO of Korro Bio, as part of the From The Trenches feature of LifeSciVC It has been an extraordinary journey so far and one that continues to humble, inspire and motivate me every day. I’ve had the honor and responsibility of building a visi on that is ambitious while being grounded in scientific rigor. Over the last 4.5 years, Korro has been built by mitigating one layer of risk at a time.
MONDAY, June 16, 2025 — A new breakthrough can help people with schizophrenia keep up with their psychiatric meds, researchers said. A pill taken just once a week, gradually releasing medicine from within the stomach, can greatly simplify the.
A team of scientists has discovered a direct link between the smell of food and feelings of fullness at least in lean mice. This brain circuit, located in the medial septum and triggered by food odors, helps animals eat less by making them feel satiated even before taking a bite. But intriguingly, obese mice lacked this response, highlighting how excess weight may interfere with this satiety mechanism.
Labuxtinib CAS 1426449-01-5 Labuxtinib, also known as EVT-8565072 , Molecular Weight 377.37 Formula C 20 H 16 FN 5 O 2 N-[5-[5-[(1R,2S)-2-fluorocyclopropyl]-1,2,4-oxadiazol-3-yl]-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide N-(5-(5-((1R,2S)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide QNX4G754W6 Labuxtinib is c-kit tyrosine kinase inhibitor.
G protein-coupled receptors (GPCRs) are a highly validated drug target family – accounting for 30-35 percent of all approved drugs. Despite this, the therapeutic potential of targeting most GPCRs remains untapped, as only 10 percent of GPCRs have been drugged. In this article, Stephan Schann, Chief Scientific Officer at Domain Therapeutics , explains why this class of drug target is so useful despite the challenges they present.
Drug Discovery 101 – Webinar Recording Starting a career in drug discovery can feel overwhelming, but breaking down the process makes it more approachable. Our Drug Discovery 101 webinar outlines the entire process from start to finish. Here’s what you need to know to begin your journey in the field. The Basics of Drug Discovery Finding the Right Target The first step in drug discovery is all about identifying and confirming a target—something in the body that a drug can influence to impro
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