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Evaluating Impurities in New Drugs to Prevent Delays in Development

The Premier Consulting Blog

Impurities or degradants that exceed qualification thresholds and have not been adequately tested in Good Laboratory Practices (GLPs) toxicology studies are often encountered during development. In addition, this guidance focuses on DNA reactive substances that could potentially cause cancer. link] ICH M7 (R2)- Q&A.

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Why Nothing Can Grow on Mars*

Codon

While astronauts are easily protected from UV by glass or a thin sheet of metal, microbes placed outside on Mars would be killed in mere minutes as the ultraviolet radiation shreds through DNA and destabilizes proteins that carry out important cellular processes. A 58-page NASA report from 2006 arrived at a similar conclusion.

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Measure Cell Metabolism with Microplate Readers | BMG LABTECH

BMG Labtech

DNA, proteins, polysaccharides, etc.). They are strongly oxidizing and, at high concentrations, are deleterious to cells damaging DNA, proteins and lipids, and eventually leading to cell death. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press. Dimroth P, 2006, Catalytic and mechanical cycles in F-ATP synthases.

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Defense-Forward Biosecurity

Codon

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

DNA 109
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The New Fungus Among Us, Candida auris

PLOS: DNA Science

It is also difficult to identify with standard laboratory methods,” summed up Mahmoud Ghannoum, director of the Center for Medical Mycology at University Hospitals Cleveland Medical Center. GISAID began in 2006 in response to bird flu, becoming a global clearinghouse for data and maps galore on epidemic and pandemic viruses.

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Is That DNA Dangerous?

Codon

Tessa Alexanian and Max Langenkamp build computational DNA screening tools for a living. A concerned employee at a laboratory supply company had called the Centers for Disease Control, or CDC, after fielding repeated calls from Harris asking when his samples of plague would arrive in the mail. Credit: Alamy In a 2006 report , the U.S.

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Analysis Chemical Thank You What we expect the EPA to do in April 2024

Agency IQ

EPA then conducted a residual risk and technology review on July 27, 2006 (71 FR 42724). EPA completed a residual risk and technology review for the NESHAP in 2006 and, at that time, concluded that no revisions to the standards were necessary. The NESHAP established standards for both major and area sources. section 7412(d)(6).