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New molecular insights on medical cannabis

Drug Target Review

He formerly worked at EMBL as a postdoctoral fellow from 2017 to 2020 where he discovered the inhibition of ATX with THC. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. The Journal of Cell Biology. 2017 Mar 9;60(5):2006–17. 2018 Jun 13;5.

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CAR-NK cells: promising for cancer therapy

Drug Target Review

By themselves, the NK cells showed limited efficacy, but anti-tumour efficacy was observed with co-treatment regimens (eg, monoclonal antibodies, haematopoietic stem cell transplants, whole body irradiation) and multiple dosing (tolerated well by patients).

Therapies 118
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Time for change: non-human primates in drug research

Drug Target Review

Experimental Biology and Medicine. Meet the author Mariana Argenziano, PhD – Associate Director Manufacturing Technologies Mariana holds a PhD in molecular biology from the University of SanMartin (Buenos Aires) and has worked at several universities in the US for more than eight years, specialising in stem cell biology.

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Cancer immunotherapy: GDF-15’s role in Anti-PD-1 resistance

Drug Target Review

in North America) in late 2017. Coordinated integrin activation by actin-dependent force during T-cell migration. Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration. Current Opinion in Cell Biology. References Nordenfelt P, Elliott HL, Springer TA.

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Precision Medicine in the Genomic Era

DrugBank

50 , 1700391 (2017). Genetics 205 , 1003–1035 (2017). 16 , 70–70 (2017). 44 , 195–211 (2017). Network expansion of genetic associations defines a pleiotropy map of human cell biology. References 1. König,  König, I. Von Mutius, E. & & Kopp, M. Bayer, R. &

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Advanced 3D cell-based technologies

Drug Target Review

In 2017, a successful in silico drug simulations were developed that represent human ventricular action potential models for routine ion channel screening, to predict pre-clinical risk of drug induced cardiac adverse effects. From 3D cell culture to organs-on-chips. Trends in Cell Biology. 2010;328(5986):1662-8.

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2025 Merkin Prize in Biomedical Technology awarded to pioneers of CAR T-cell therapy

Broad Institute

A similar CAR from another company, Kite Pharmaceuticals (now a Gilead company), was approved by the FDA in 2017 as the second commercial CAR T-cell therapy. After their clinical results, their technology was licensed to Juno Therapeutics (later acquired by Bristol Myers Squibb.)

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