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A Visual Guide to Genome Editors

Codon

The core of the CRISPR immune response is a guide RNA (gRNA) that binds to a CRISPR-associated (Cas) protein. If the same virus invades the cell a second time, the gRNA’s spacer sequence will bind to the matching viral DNA sequence, then be cut by the Cas protein. Visit our website to get a copy. Join Asimov Press.

DNA
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AZVUDINE

New Drug Approvals

8] It costs 350 Chinese yuan per 7 days for COVID, as of November 2022. [9] SYN [link] Azvudine was approved for the treatment of adult HIV-1 infection in China in 2021, and it was approved for conditional marketing for the treatment of SARS-CoV-2 in China in 2022. 2022, 55, 565−578. (8) 2024, 67, 4376−4418 Azvudine (1).

RNA
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Simple test for flu could improve diagnosis and surveillance

Broad Institute

Simple test for flu could improve diagnosis and surveillance By Allessandra DiCorato June 18, 2024 Breadcrumb Home Simple test for flu could improve diagnosis and surveillance A low-cost CRISPR-based paper strip test distinguishes between influenza types and can be reprogrammed to recognize different viruses including the H5N1 bird flu virus.

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Targeting a human protein may stop Ebola virus in its tracks

The Pharma Data

To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase. Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Drugs that target polymerase could potentially treat Ebola virus infections and save lives.

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Phages could help to tackle antimicrobial resistance

Drug Target Review

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. The novel, hairpin-shaped molecule was named cabRNA for CBASS-activating bacteriophage RNA.

RNA
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Moderna to Build mRNA Vaccine Portfolio Following COVID-19 Success | 2021-01-11

The Pharma Data

Moderna is following up on the success of its messenger RNA-based COVID-19 vaccine with plans to develop inoculations for numerous other infectious diseases, the company said Monday. billion doses in 2022, he said. 18, 2020 ). It has already received $2.8 billion from customers for the future supply of its COVID-19 vaccine, out of $11.7

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Afimetoran

New Drug Approvals

TLR7-9 are among the set that are endosomally located and respond to single-stranded RNA (TLR7and TLR8) or unmethylated single-stranded DNA containing cytosine-phosphate-guanine (CpG) motifs (TLR9). Toll/IL-1 receptor family members are important regulators of inflammation and host resistance. Nature Immunol., 11:373-384 (2010)).

RNA