Broad Institute

JANUARY 6, 2025

By Leah Eisenstadt January 6, 2025 Credit: Courtesy of the Xavier and Schreiber labs. Related groups Xavier lab Over the past two decades, large genetic studies have linked tens of thousands of DNA variants to thousands of human traits and diseases. The new work appears in Cell Chemical Biology.

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Disease Research DNA Small Molecule 139

Drugs.com

MAY 15, 2025

THURSDAY, May 15, 2025 — The 2023 approval of the first drug shown to slow the progression of Alzheimer’s disease came with no small amount of concern from skeptics. Lecanemab (Leqembi) modestly slows Alzheimer’s by helping the.

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Drugs Disease 275

Drugs.com

MAY 1, 2025

THURSDAY, May 1, 2025 -- The cutting-edge weight-loss drug Ozempic/Wegovy can stop and even reverse fatty liver disease, a new clinical trial has found.Nearly twice as many people taking semaglutide stopped their fatty liver disease without further.

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Disease Clinical Trials Trials Drugs 277

Science Daily: Pharmacology News

JANUARY 15, 2025

Most treatments being pursued today to protect against Alzheimer's disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research points to a novel -- and noble -- approach: using Xenon gas. A phase 1 clinical trial of the treatment in healthy volunteers will begin in early 2025.

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Disease Clinical Trials Treatment Trials 290

Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- An experimental blood test for Alzheimers disease not only can aid in its diagnosis but also indicate how far the brain condition has progressed, a new study says.The test tracks levels of a protein called MTBR-tau243, w.

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Disease 276

Drugs.com

APRIL 17, 2025

THURSDAY, April 17, 2025 -- Common medications like aspirin, ibuprofen, statins and beta blockers appear to slow the progress of Parkinsons disease, a new study says.Parkinsons symptoms took nearly a decade longer to crop up in patients taking the.

Disease 278

Disease 278

Drugs.com

JUNE 12, 2025

THURSDAY, June 12, 2025 — Most folks tap away at their smartphone for fun, communication or information.But such tapping may also help them track the progress of a rare degenerative brain disease, researchers say.Five simple smartphone-measured t.

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Disease Research 162

Drugs.com

JANUARY 13, 2025

13, 2025 -- Gum disease appears to disrupt brain activity, potentially increasing a persons risk of cognitive decline.People with gum disease experienced altered connections between different brain regions, compared to folks with good. MONDAY, Jan.

Disease 246

Disease 246

Drugs.com

MAY 23, 2025

FRIDAY, May 23, 2025 A new White House report says todays children are the sickest generation in U.S. history when it comes to chronic disease, and it puts the blame on environmental toxins, poor nutrition and too much screen time.Called the "MA.

Disease 162

Disease 162

Drugs.com

FEBRUARY 25, 2025

25, 2025 -- Many Americans don't realize how everyday habits and overlooked health issues can increase their risk for heart disease, according to a new Cleveland Clinic survey. TUESDAY, Feb. The nationwide survey found numerous gaps in heart health.

Disease 240

Disease 240

Drugs.com

APRIL 24, 2025

THURSDAY, April 24, 2025 -- Women suffering from urinary incontinence might have a greater risk of heart disease, a new study says.Women who struggle with bladder control are more likely to have risk factors associated with heart health problems.

Disease 231

Disease 231

Drugs.com

MAY 19, 2025

MONDAY, May 19, 2025 Couch potatoes are more likely to develop Alzheimers disease, even if they set aside time to work out each day, a new study says.People who spent more time sitting around were more likely to experience cognitive decline and b.

Disease 162

Disease 162

Covalent Modifiers

DECEMBER 28, 2024

Ai-Lin Chen, Zih-Jheng Lin, Hsiao-Yu Chang, and Tsung-Shing Andrew Wang Journal of the American Chemical Society , 2025 [link] Reactive carbonyl species (RCS) are important biomarkers of oxidative stress-related diseases because of their highly reactive electrophilic nature.

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Disease Production 182

Drugs.com

MAY 21, 2025

WEDNESDAY, May 21, 2025 Battling chronic disease really takes it out of a person, leaving them vulnerable to depression.And people with multiple long-term health problems are even more likely to fall prey to depression, a new study says.Some c.

Disease 147

Disease 147

Drugs.com

APRIL 10, 2025

THURSDAY, April 10, 2025 -- Having a father with Alzheimers disease could put you at risk for brain changes linked to the degenerative disorder, a new study says.People whose fathers fell prey to Alzheimers had a greater spread of tau proteins in.

Disease 221

Disease 221

Drugs.com

FEBRUARY 6, 2025

6, 2025 -- The U.S. THURSDAY, Feb. Food and Drug Administration has approved Onapgo (apomorphine hydrochloride) injection as the first and only subcutaneous apomorphine infusion device for the treatment of motor fluctuations in patients with.

FDA Approval 277

FDA Approval Disease FDA Treatment 277

Drugs.com

JUNE 13, 2025

FRIDAY, June 13, 2025 — A person’s microbiome – the bacteria naturally living in the mouth and gut – might contribute to Parkinson’s disease, a new study says.Specific changes in these bacteria are associated with cognitive decline in Parkinson’s, r.

Disease 237

Disease 237

BioPharma Drive: Drug Pricing

OCTOBER 18, 2024

Detailed data from a Phase 2b/3 study of Merck’s treatment clesrovimab should support the company’s efforts to win approval by the 2025-2026 season.

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Hospitals Disease Trials Treatment 274

Drugs.com

APRIL 21, 2025

MONDAY, April 21, 2025 -- An oral chemotherapy drug can safely and effectively manage sickle cell disease in children, a new study says. Children taking hydroxyurea had fewer ER visits and spent fewer days in the hospital compared to kids not.

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Disease Hospitals Drugs 213

Drugs.com

JUNE 11, 2025

WEDNESDAY, June 11, 2025 — Want to reduce your risk of dementia and Alzheimer’s disease? Get on your bike and ride, a new study recommends. Biking regularly for transportation appears to lower risk of dementia by 19% and.

Disease 240

Disease 240

Drugs.com

MAY 5, 2025

MONDAY, May 5, 2025 Can gluten be passed on through a kiss?Its Its a concern for some folks with celiac disease, but a new study says worry not. People with celiac disease had no problems after kissing a partner whod just eaten a stack of saltine cr.

Disease 162

Disease 162

Drugs.com

APRIL 25, 2025

FRIDAY, April 25, 2025 -- Doctors can accurately predict a persons risk of fatty liver disease as early as 16 years before symptoms develop, a new study says.A blood test looking for five specific proteins can predict metabolic d.

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Disease Doctors 189

Drugs.com

APRIL 21, 2025

MONDAY, April 21, 2025 -- An oral chemotherapy drug can safely and effectively manage sickle cell disease in children, a new study says.Children taking hydroxyurea had fewer ER visits and spent fewer days in the hospital compared to kids not taking.

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Disease Hospitals Drugs 195

Broad Institute

MAY 21, 2025

Scientists create next generation of tools in battle against brain disease By Corie Lok May 21, 2025 Breadcrumb Home Scientists create next generation of tools in battle against brain disease The findings contained in eight studies could lead to targeted gene therapies for brain disorders.

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Disease Medical Schools DNA Therapies 72

Drugs.com

FEBRUARY 13, 2025

13, 2025 -- If you've got a big belly, diabetes or high blood pressure, you may want to limit your alcohol, experts warn, as drinking could significantly raise your odds for serious liver disease.The research, published recently in. THURSDAY, Feb.

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Disease Research 245

Conversations in Drug Development Trends

APRIL 29, 2025

On the last day of February every year is Rare Disease Day , a dedicated day to celebrate the rare disease community, including patients, families, caregivers, clinicians, researchers, regulators, and more. The goal is to build community, share ideas and resources, and advance research and innovation.

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Disease Clinical Trials FDA Trials 69

Covalent Modifiers

FEBRUARY 10, 2025

DOI Ansgar Oberheide, Maxime van den Oetelaar, Jakob Scheele, Jan Borggrfe, Semmy Engelen, Michael Sattler, Christian Ottmann, Peter Cossar and Luc Brunsveld RSC Med Chem 2025 [link] Protein-protein interactions (PPIs) are key regulators of various cellular processes.

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Biophysical Assays Small Molecule Engineering Regulations 173

Drugs.com

MARCH 24, 2025

MONDAY, March 24, 2025 -- The U.S. Food and Drug Administration has approved Tremfya (guselkumab) for adult patients with moderately to severely active Crohn disease.This approval is the fourth indication for this dual-acting interleukin-23.

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FDA Approval Disease FDA Drugs 227

Elrig

MARCH 25, 2025

It will also cover recent advancements in broadening their application, including innovative approaches to ensure their safety and efficacy, the use of targeted delivery to reach disease-relevant tissues as well as success stories in bringing therapeutic oligonucleotides to the clinic.

RNA 59

RNA Bioinformatics Science Pharmacokinetics 59

Covalent Modifiers

MAY 18, 2025

Nafizul Haque Kazi, Nikolas Klink, Kai Gallant, Gian-Marvin Kipka & Malte Gersch Nat Struct Mol Biol , 2025 [link] The mitochondrial deubiquitinase ubiquitin-specific protease (USP) 30 negatively regulates PINK1parkin-driven mitophagy.

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Engineering Regulations Small Molecule Clinical Trials 147

BioPharma Drive: Drug Pricing

JANUARY 9, 2025

Political and economic uncertainty hangs over the industry, while major bets on metabolic and immune disease drug research are set to play out.

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Drug Research Disease Research Drugs 176

Drugs.com

JANUARY 2, 2025

2, 2025 -- Cases of a bacterial infection called rabbit fever have been increasing during the past decade.Cases of tularemia increased by 56% during the 2010s compared to the previous decade, researchers report in the CDCs Morbi. THURSDAY, Jan.

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Disease Research 246

Conversations in Drug Development Trends

NOVEMBER 5, 2024

In preparation for World Orphan Drug Congress Europe, we interviewed Nathan Chadwick, Senior Director, Therapeutic Strategy Lead, Rare Disease, and Derek Ansel, MS, LCGC, Vice President, Therapeutic Strategy Lead, Rare Disease, to hear their insights into the current progress in rare disease research and their hopes for 2025.

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Disease Clinical Trials Therapies Clinical Research 52

Drugs.com

FEBRUARY 27, 2025

27, 2025 -- With egg prices soaring due to a severe bird flu outbreak, the U.S. Department of Agriculture (USDA) announced a $1 billion plan to contain the disease and help poultry farmers recover. THURSDAY, Feb. The outbreak has destroyed flocks.

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Disease 291

Drugs.com

MARCH 17, 2025

MONDAY, March 17, 2025 -- For 21 years, Sebastien Beauzile lived with the chronic pain of sickle cell anemia. Now, thanks to a groundbreaking genetic treatment, he is the first person in New York to be cured of the disease. Sickle cell was like.

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Treatment Disease 290

Drugs.com

JANUARY 6, 2025

6, 2025 -- Rates of whooping cough in the U.S. continue to climb, according to data from the US Centers for Disease Control (CDC).Over MONDAY, Jan. Over 32,000 cases reported have been reported as of mid-December -- about six times more than there were.

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Disease 289

Drugs.com

JANUARY 16, 2025

16, 2025 -- The U.S. Food and Drug Administration has approved Omvoh (mirikizumab-mrkz) for the treatment of moderately to severely active Crohn disease in adults, according to a press release from Eli Lilly and Company.Omvoh targets. THURSDAY, Jan.

FDA Approval 162

FDA Approval Disease FDA Treatment 162