Chemical Biology and Drug Design

MAY 10, 2025

The review focused on English-language original research and review articles, examining carprofen and its derivatives in terms of their synthesis methods as well as their use as small molecules in various therapeutic applications, both human and veterinary.

Small Molecule 100

Small Molecule Drug Development Science Therapies 100

Drug Patent Watch

DECEMBER 30, 2024

This article aims to provide a comprehensive overview of the key aspects of the regulatory framework, highlighting the requirements and challenges faced by pharmaceutical companies seeking to introduce generic drugs into the Japanese market.

Drug Development 52

Drug Development Clinical Pharmacology Clinical Trials Pharmaceutical Companies 52

Drug Patent Watch

DECEMBER 11, 2024

In this article, we will delve into the key criteria for selecting a CDMO, highlighting the essential factors to consider and the importance of effective communication and cultural fit. Your Drugs Development Stage The stage of your drug development is a critical factor in selecting a CDMO.

Pharmaceutical Companies 94

Pharmaceutical Companies Compliance Pharmaceuticals Drug Development 94

Drug Target Review

MARCH 24, 2025

Having previously drawn parallels with industry adoption of electronic lab notebooks in part 1 , this article expands on his vision for the future of the industry, sharing his forward-thinking ideas and practical recommendations.

Clinical Trials 59

Clinical Trials Animal Testing Drugs Pharmacokinetics 59

Drug Target Review

JANUARY 14, 2025

In the next article, we will discuss the tools scientists can use to execute the workflow described in Figure 1. Here, it is helpful to toggle between two mindsets: one of a creative scientist, useful for creating avenues of exploration, and one of a critic when assessing the merit of these avenues.

Drugs 69

Drugs Protein Expression Science Research 69

Drug Patent Watch

DECEMBER 10, 2024

In this article, we will delve into the benefits of working with integrated CDMO services and explore how they can streamline the drug development and manufacturing process. This shift has led to the emergence of integrated contract development and manufacturing organizations (CDMOs), which provide end-to-end support for drug developers.

Drug Development 82

Drug Development Compliance Pharmaceutical Companies Drugs 82

Chemical Biology and Drug Design

MARCH 26, 2025

In this article, we present the synthesis of novel 3-phenyl-1-((1-aryl-1 H -1,2,3-triazol-5-yl)methyl)spiro[indoline-3,2-oxiran]-2-one derivatives by the regioselective reaction of sulfur ylides with 1,2,3-triazole-tethered isatins and their anticancer effects on hepatocellular carcinoma (HCC) cells HepG2 and HCCLM3.

Research 100

Research 100

Chemical Biology and Drug Design

NOVEMBER 4, 2024

This review article comprehensively summarized the recent advancements in galantamine and its hybrid analogs as potential therapeutic agents for the management of AD. Alzheimer's disease (AD) is a progressive age-related neurodegenerative brain disorder that destroys memory and other important mental functions.

Disease 100

Disease Therapies Research 100

Drug Target Review

DECEMBER 11, 2024

In this article, we share our hard-earned insights into overcoming these critical challenges. Despite these advancements, analysing biologically derived targets remains a formidable challenge due to interference from endogenous molecules.

International 52

International Laboratories Drugs Pharmacokinetics 52

BioPharma Drive: Drug Pricing

JULY 8, 2025

You can unsubscribe at anytime.

Targeted Protein Degradation 144

Targeted Protein Degradation Small Molecule Disease Therapies 144

Drug Patent Watch

JANUARY 15, 2025

This article explores the limitations of Google Patents in this context and suggests alternative approaches. Identifying drug patents is crucial for various stakeholders, including researchers, legal professionals, and business strategists.

Drugs 52

Drugs Pharmaceuticals Engineering Research 52

Chemical Biology and Drug Design

MAY 12, 2025

This article outlines the current antiretroviral therapy and its adverse effects but also CRISPR/Cas technology. This review article also discusses its mechanism of action and potential applications in the treatment of HIV/AIDS. Furthermore, it enhances our understanding of fundamental genetics.

Treatment 100

Treatment Therapies DNA RNA 100

Drug Target Review

JUNE 16, 2025

This article explores the principles, applications and future potential of MSI in drug development. 2024, Article ASAP. Additionally, MSI aids in the identification of reliable biomarkers for early toxicity detection, supporting clinical safety and risk mitigation. Proteome Res. Vezzali E, Becker M, Romero-Palomo F, et al.

Drugs 52

Drugs Organic Chemistry Laboratories Pharmaceuticals 52

Covalent Modifiers

DECEMBER 21, 2024

Nir London Chemical Reviews Article ASAP DOI: 10.1021/acs.chemrev.4c00570 4c00570 Molecules that are able to induce proximity between two proteins are finding ever increasing applications in chemical biology and drug discovery.

Drugs 162

Drugs 162

Drug Target Review

JULY 3, 2025

It is becoming increasingly evident that generative artificial intelligence (GenAI) is a resourceful tool for helping pharmaceutical companies reduce manual tasks required by clinical trials.

Drug Development 65

Drug Development Drugs Animal Testing Engineering 65

LifeSciVC

MAY 14, 2025

Thank you to my friend and colleague Matt Sears for his contributions to this article. Hope is as important a variable as the economics. After all, science fiction vs. science fact is often a product of perception. References DeLucas, L J et al. Protein crystal growth in microgravity. Science vol. 246,4930 (1989): 651-4. Ma, Chiyuan et al.

Science 96

Science Production Research Drugs 96

Drug Patent Watch

FEBRUARY 10, 2025

Read the full article on streamlining the generic drug supply chain best practices: [link] By working together, manufacturers, distributors, and regulators can create a more efficient and patient-centric generic drug supply chain. What do you think is the biggest challenge facing the generic drug supply chain today?

Drugs 71

Drugs Regulations Production 71

Drug Target Review

DECEMBER 20, 2024

Artificial intelligence (AI) has revolutionised many industries, yet its adoption in pharmaceutical drug development has been notably slower. Concerns surrounding data security, the complexity of AI systems, and the rigorous regulatory frameworks in this field have caused the pharmaceutical industry to approach these technologies with caution.

Clinical Trials 128

Clinical Trials Trials Pharmaceuticals Drug Development 128

Drug Target Review

JULY 1, 2025

Clinical trials are expensive, slow and often limited by outdated design constraints. Placebo arms, in particular, create ethical and logistical hurdles, especially in areas like rare disease and oncology. Digital twins offer a way forward.

Clinical Trials 100

Clinical Trials Trials FDA Disease 100

Chemical Biology and Drug Design

JULY 16, 2025

Zoledronic acid was identified as a lead hit targeting ZNF726 activity, inhibiting its proliferative effects on breast cancer cells. Zoledronic acid inhibits cellular cholesterol level through the inhibition of ZNF726 activity in breast cancer cells.

Treatment 100

Treatment Research 100

Chemical Biology and Drug Design

JULY 3, 2025

Computationally guided modifications of centaureidin led to the development of CA4, demonstrating enhanced antioxidant and antitumor activities. Molecular docking and in vitro assays confirm improved binding affinity and cytotoxicity, highlighting CA4's potential as a promising drug candidate for cancer therapy.

Drug Development 100

Drug Development Drugs Therapies Production 100

Drug Target Review

JULY 21, 2025

In Part 2 of our conversation with Layla Hosseini-Gerami, Chief Data Science Officer at Ignota Labs , we explore the many forms of toxicity and how AI-powered tools like omics and cell painting are transforming early prediction in pre-clinical research.

Drugs 73

Drugs RNA Bioinformatics Science 73

Drug Target Review

DECEMBER 9, 2024

The 2024 Nobel Prize in Chemistry was awarded to Demis Hassabis and John Jumper from Google DeepMind for developing AlphaFold2, and to David Baker from the University of Washington for his work in computational protein design. These innovations have revolutionised the understanding of protein structures using artificial intelligence.

Engineering 106

Engineering International Drug Development Science 106

Drug Target Review

JULY 21, 2025

Hundreds of life-altering conditions attack the central nervous system (CNS). Disorders such as Alzheimer’s disease , primary glioblastoma and amyotrophic lateral sclerosis (ALS) all affect the CNS and are considered fatal, while more common conditions, including depression , strokes and epilepsy , require long-term treatments.

Drug Development 65

Drug Development Small Molecule Drugs Therapies 65

Drug Target Review

JUNE 17, 2025

In 2003, the completion of the Human Genome Project was celebrated as the start of a new era in medicine. However, even though genome sequencing can now be completed in a single day at a fraction of the original cost, and despite the exponential increase in data generation, nearly two decades later the clinical impact of genomics has been limited.

RNA 72

RNA Engineering DNA Disease 72

Drug Target Review

APRIL 7, 2025

As our understanding of the underlying biology of disease grows more sophisticated, emerging therapies operate on increasingly complex biopathological systems and mechanisms.

Clinical Development 69

Clinical Development Clinical Trials Clinical Pharmacology Trials 69

Drug Target Review

JUNE 30, 2025

Drug discovery often pushes the boundaries of what we understand. John Lepore, MD, CEO of ProFound Therapeutics and CEO-Partner at Flagship Pioneering , is furthering that challenge by redefining where and how we search for new medicines.

Disease 59

Disease Medical Schools Science Therapies 59

Drug Target Review

JULY 24, 2025

Antibody therapies have transformed cancer treatment, yet their limits are becoming increasingly clear – particularly when tumours evolve, evade immune detection or develop resistance to existing drugs. For Dr Jhong-Jhe ‘JJ’ You, Vice President of Antibody Discovery at AP Biosciences, these challenges are not setbacks. They are starting points.

Immune Response 52

Immune Response Engineering Cell Based Assays Therapies 52

Perficient: Drug Development

MAY 27, 2025

Using the Blog plugin, individuals can publish articles, share insights, and engage with readers. Ideal for websites that need a news section, articles, or traditional blog features. Can include forms, analytics, and customer portals as needed. The backend is simple enough for non-technical users to create and manage posts.

Engineering 52

Engineering Testimonials Production Marketing 52

Drug Target Review

JUNE 16, 2025

In this article, Stephan Schann, Chief Scientific Officer at Domain Therapeutics , explains why this class of drug target is so useful despite the challenges they present. G protein-coupled receptors (GPCRs) are a highly validated drug target family – accounting for 30-35 percent of all approved drugs.

Disease 59

Disease Therapies Small Molecule Immune Response 59

Chemical Biology and Drug Design

JUNE 9, 2025

A series of small molecule PD-L1 inhibitors was discovered via optimization of the solvent-interaction region. GJ19 showed the most potent anti-PD-L1 effects with an IC 50 of 32.06 nM. GJ19 (i.p., 15 mg/kg) effectively suppressed tumor growth with a TGI of 56.8% in a B16-F10 melanoma mouse model.

Small Molecule 100

Small Molecule Research 100

Drug Patent Watch

DECEMBER 10, 2024

This article delves into India’s growing importance in generic drug API manufacturing, highlighting the key factors contributing to its success and the challenges it faces.

Government 89

Government Drugs Pharmacy Pharmaceuticals 89

Drug Target Review

JUNE 9, 2025

The landscape of genetic medicine is undergoing a profound transformation, driven by innovative approaches that challenge the traditional, disease-specific paradigms.

Disease 80

Disease Treatment Engineering Protein Production 80

FDA Law Blog: Drug Discovery

APRIL 21, 2025

Some regulatory actions or inactions like the three cited in the WSJ article may not be attributable to anything other than the machinations of a large agency and are of the sort that have plagued clients for years.

FDA 64

FDA Drug Development Drugs International 64

Drug Target Review

FEBRUARY 10, 2025

In the rapidly advancing field of cell therapies, Dr Jason Bock has emerged as a leader, known for his innovative approach to optimising the development process. With over 25 years of experience in therapeutics, Bock has played a pivotal role in shaping the future of cell therapies, particularly through his work at CTMC.

Therapies 65

Therapies Treatment Engineering Clinical Trials 65

Drug Target Review

JULY 19, 2025

Maria Knaub, Senior Medical Affairs Operations Lead at Terumo Blood and Cell Technologies (Terumo BCT), brings a unique blend of frontline experience and scientific expertise to the fore of cell therapy innovation.

Therapies 52

Therapies Clinical Trials Trials Research 52

Quanticate

JULY 16, 2025

This article is based on the final, Step 4 version of the ICH E6(R3) Good Clinical Practice guidance, officially adopted on 6 January 2025 by the International Council for Harmonisation. This Step 4 document is the version recommended for regulatory adoption across all ICH member regions.

Clinical Trials 52

Clinical Trials Trials International 52