article thumbnail

Case study: gget’s new Open Target module

The Open Targets Blog

  “Sam has an exceptional talent in software engineering, and his contributions reflect a deep understanding of both the technical and biological aspects required for bioinformatics tool development,” says Laura Luebbert, now a postdoctoral fellow in the Sabeti lab at the Broad Institute of MIT and Harvard and Harvard University.

article thumbnail

The first major set of genetic associations found in long COVID

Drug Target Review

Combinatorial analytics approaches identify combinations of features that together are associated with the disease phenotype in patient sub-groups, capturing the non-linear effects of interactions between multiple genes. The combinatorial approach is considerably more sensitive than GWAS and requires much smaller patient populations.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Genomic score predicts patients' progression to multiple myeloma

Broad Institute

The score, called an MM-like score, assesses the severity of disease and risk of progression to active cancer, with higher scores indicating faster progression. The MM-like score defined in this study focuses on the presence and progressive evolution of genetic abnormalities to assess the state of the disease.

DNA 52
article thumbnail

Advancing vaccine design: potential of peptide mimicry

Drug Target Review

1 The study reveals a novel bioinformatic approach and tool that holds the potential to empower researchers in designing vaccines capable of inducing a stronger immune response. By selecting specific segments of proteins that elicit robust immune reactions, these vaccines could offer enhanced protection against diseases.

Vaccine 98
article thumbnail

Therapeutic Oligos 2025 Keynote Speakers Announced

Elrig

It will also cover recent advancements in broadening their application, including innovative approaches to ensure their safety and efficacy, the use of targeted delivery to reach disease-relevant tissues as well as success stories in bringing therapeutic oligonucleotides to the clinic.

RNA 59
article thumbnail

Stachydrine represses the proliferation and enhances cell cycle arrest and apoptosis of breast cancer cells via PLA2G2A/DCN axis

Chemical Biology and Drug Design

Chinese motherwort (YiMuCao, Leonurus japonicus ) is a traditional Chinese herb showing beneficial effects for obstetrical and gynecological diseases. Then, Bioinformatics was applied to sort out the candidate interacting with Stachydrine as well as its expression and downstream target in BC.

article thumbnail

Case study: NCI’s Molecular Targets Platform

The Open Targets Blog

Data integration under common ontological terms will aid in categorising diseases, genes, and agents. Open Targets delivers easy-to-navigate aggregated information and evidence linking therapies, genes, and diseases.  The Open Targets Platform had several advantages as a backbone infrastructure for this purpose. earlier this year.