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Combination of Metabolomics and Bioinformatics to Reveal the Mechanism of Luteolin in the Treatment of Cervical Cancer

Chemical Biology and Drug Design

The remarkable therapeutic potential of luteolin against cervical cancer can be ascribed to its profound influence on amino acid and nucleotide metabolism, substantiated by the seamless integration of metabolomics, bioinformatics, and molecular docking techniques in this comprehensive investigation.

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Spalt‐Like Transcription Factor 4 Mediates Fatty Acid Oxidation to Foster 5‐Fluorouracil Resistance in Gastric Cancer Cells

Chemical Biology and Drug Design

ABSTRACT Platinum-based and pyrimidine drugs are first-line treatments for gastric cancer (GC), but their efficacy is often affected by drug resistance. Spalt-like transcription factor 4 (SALL4) mediates fatty acid oxidation (FAO) promotes 5-fluorouracil (5-FU) resistance in gastric cancer (GC) cells.

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NGS is evolving: collaboration and tech lead the way

Drug Target Review

The findings underscored that automation improves data consistency and quality, thereby supporting more accurate diagnostics and personalised treatment strategies. The findings underscored that automation improves data consistency and quality, thereby supporting more accurate diagnostics and personalised treatment strategies.

RNA 92
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Scientific workflow for hypothesis testing in drug discovery: Part 1

Drug Target Review

In cases where control or treatment groups show large variability, this could reflect true biological responses to a treatment, and removing such data could reduce the accuracy of the analysis. It is crucial during this phase to strike a balance between removing erroneous data and preserving meaningful biological variability.

RNA 52
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From siloed data to breakthroughs: multimodal AI in drug discovery

Drug Target Review

Drug development faces significant challenges: long timelines, high costs , complex processes and low probabilities of success (PoS), exacerbated by the shift towards more complex molecules, biologics and cell and gene therapies, hindering patient access to vital treatments. Highly accurate protein structure prediction for the human proteome.

Drugs 65
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Fixing failed drugs: AI solutions for toxicity in drug discovery – part 3

Drug Target Review

The statistics are sobering – 56 percent of drug candidates failing due to safety issues represents an enormous waste of scientific potential and investment capital, alongside delayed treatments for patients. She also produced several publications in collaboration with Eli Lilly, leading industry translation of her academic research.

Drugs 59
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Therapeutic Oligos 2025 Keynote Speakers Announced

Elrig

Prof Rory Johnson is an Associate Professor at University College Dublin, where his research focusses on uncovering the roles of long noncoding RNAs (lncRNAs) in human health and disease using an interdisciplinary combination of bioinformatic and experimental methods.

RNA 59