PerkinElmer

JULY 13, 2020

Imaging Modalities Help Visualize and Confirm Findings An emerging method of studying viruses is by using high-content imaging solutions to visualize the activity of small interfering RNA (siRNA), also known as short interfering RNA or “silencing” RNA.

RNA 52

RNA Virus Laboratories Science 52

NIH Director's Blog: Drug Development

SEPTEMBER 29, 2015

As an important step in this direction, NIH-funded researchers at the Morgridge Institute for Research and University of Wisconsin-Madison have produced neural tissue chips with many features of a developing human brain. The sequencing data reflect the genomic activity within the organoid following exposure to each of the 60 compounds.

RNA 52

RNA Science Laboratories Clinical Trials 52

BMG Labtech

OCTOBER 4, 2023

In this blog, we examine how quality control of nucleic acids on microplates before sequencing can facilitate next-generation sequencing and look at some of the emerging next-generation sequencing solutions available to researchers. If RNA is being sequenced it is first converted to cDNA by reverse transcription.

DNA 52

DNA RNA Bioinformatics Research 52

Dark Matter Blog

JULY 19, 2021

However, in June I happened to attend the Gordon Research Conference on Chemical Biology and High-throughput Chemistry where I saw a session on small molecules and RNA. Making small-molecule drugs against RNA structures looked like a really cool problem – I want to do THAT! This is a thing? I did NOT get the email.

RNA 52

RNA Small Molecule Science Therapies 52

The Open Targets Blog

AUGUST 15, 2023

Research in mice has shown that RBM3 expression is protective against misfolded protein damage, suggesting the protein as an interesting target in the development of therapies for neurodegenerative conditions such as Alzheimer’s disease. What are the next steps in this research? Where did the idea for this project come from?

RNA 52

RNA Treatment Regulations DNA 52

The Open Targets Blog

MAY 23, 2024

In a paper published today in Nature Communications , Open Targets researchers and collaborators used single-cell RNA sequencing to create a high resolution molecular map of immune cells in NSCLC tumours, to better understand the role of these cells in disease progression. This could then pave the way for subtype-specific therapies.

RNA 57

RNA Disease Clinical Trials Therapies 57

LifeSciVC

JULY 1, 2024

So when I was asked recently to share advice to a group of undergraduate students doing research at Penn State, I was drawn to the idea of connecting scientific principles to some life lessons. The central dogma of molecular biology is that information generally (with few exceptions) flows from DNA to RNA to Protein.

Science 92

Science Immune Response Molecular Biology RNA 92

New Drug Approvals

JANUARY 31, 2024

citation needed ] The pharmacokinetic properties of obeldesivir and improved was first published by Chinese researchers in May 2022. 2-NTP , an analog of ATP, inhibits the SARS-CoV-2 RNA-dependent RNA polymerase replication and transcription of viral RNA. The collected fractions were concentrated to give Intermediate 2.

RNA 52

RNA Science Treatment Pharmacokinetics 52

The Strateos Blog: Drug Discovery

DECEMBER 13, 2021

Learn how Strateos’ automated synthetic biology modules supported rapid, iterative screening of RNA sequences in modular pbuE expression system and E. Owing to their modular organization, riboswitches are ideal for engineering de novo sensing elements for use in synthetic biology. coli extract-based cell-free protein expression assays.

Engineering 52

Engineering Protein Expression Research Laboratories RNA 52

PerkinElmer

JANUARY 19, 2020

You need to return from SLAS in San Diego with new tools to raise your scientific research… your “Out of the Office ROI.” Time away from the lab is limited and valuable.

International 52

International RNA DNA Science 52

Dark Matter Blog

JULY 19, 2021

We bid our head of research and employee #005, Jim Barsoum, au revoir , as he marches bravely into a well-earned retirement. Today, we reach a bittersweet transition at Arrakis.

Small Molecule 52

Small Molecule RNA Science Therapies 52

Conversations in Drug Development Trends

APRIL 15, 2025

This blog provides an overview of key biomarkers for five major neurodegenerative diseases: Alzheimers disease (AD), Parkinsons disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Huntingtons disease (HD).

Clinical Trials 40

Clinical Trials Trials Disease RNA 40

Alta Sciences

APRIL 17, 2024

Five Promising Treatment Areas in Early-Phase Drug Development in 2024 aasimakopoulos Wed, 04/17/2024 - 15:52 Early-phase drug development is an ever-changing landscape, as emerging science leads to new promising areas of research for the treatment of human health issues.

Drug Development 52

Drug Development Treatment Drugs FDA Approval 52

The Open Targets Blog

FEBRUARY 29, 2024

Open Targets actually has some research projects in this area. The Open Targets Platform uses quite a lot of bulk RNA expression data, to inform on target expression profiles and disease associations, and the team is currently investigating the best way to integrate single cell expression data as well.

International 57

International Bioinformatics RNA Disease 57

Dark Matter Blog

AUGUST 27, 2020

A few years ago, at Arrakis Therapeutics, we set out to conquer a strange new territory, drugging RNA structures with small molecules. In fact, it was these early pharmaceutical successes that gave us the confidence that we would ultimately succeed in systematically drugging a wide range of RNA structures.

Small Molecule 52

Small Molecule RNA Clinical Trials Drugs 52

Codon

FEBRUARY 20, 2024

More than two decades ago, though, some researchers in Tsukuba, Japan figured out a way to get around this problem and watch ATP synthase as it spins. In 2008, researchers at UC Berkeley devised an ingenious solution. The protein is too small and moves too fast. But again, how do we know? It’s an astonishing experiment.

RNA 98

RNA DNA Engineering Cell Biology 98

BMG Labtech

DECEMBER 20, 2024

Absorbance measurements, often referred to as light absorbance, are so versatile and widespread that they are one of the first techniques many life science researchers encounter in a practical setting. In this blog, we examine the utility of absorbance and optical density measurements, including examples where microplate readers can help.

DNA 52

DNA Science Laboratories RNA 52

PLOS: DNA Science

JUNE 13, 2024

The virus SARS-CoV-2 emerged in Wuhan, home of a premiere research institute that focuses on viruses. A year before the initial outbreak, Wuhan researchers proposed nurturing a coronavirus with enhanced ability to attach onto, and enter, human cells. Her points: 1. Shortly thereafter, some workers became sick.

Virus 52

Virus RNA DNA Science 52

Dark Matter Blog

APRIL 8, 2020

Most people, and in particular most investors we spoke to in those early days, thought we were nuts – that RNA lacked the structural and molecular complexity that medicinal chemistry exploits with such great effect for proteins. One is that molecular recognition is purely a matter of physics and RNA has to play by the same rules.

RNA 52

RNA Small Molecule Synthetic Chemistry Science 52

Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. Nucleic Acids Research. A giant dataset about the rat brain, and how neurons connect to each other, was collected and pooled together from 20 different research laboratories. Nucleic Acids Research.

DNA 52

DNA RNA Engineering Licensing 52

Codon

JULY 27, 2023

For a recent study, researchers edited 21 different genes in poplar trees, a species commonly used to make paper. The researchers studied trees with 70,000 different gene-editing combinations, just 0.5% Because it turns out that at least half of them , in humans, also bind to RNA molecules. Max Berry left an excellent comment.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

For a recent study, researchers edited 21 different genes in poplar trees, a species commonly used to make paper. The researchers studied trees with 70,000 different gene-editing combinations, just 0.5% Because it turns out that at least half of them , in humans, also bind to RNA molecules. Max Berry left an excellent comment.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JANUARY 24, 2024

The researchers began by taking beta cells from people with early-stage diabetes and from people without diabetes. To ensure that this problem stemmed from beta cells themselves and not the pancreas as a whole, the researchers transplanted the diabetic beta cells and the healthy beta cells into healthy mice, and – voila!

Science 76

Science Disease Research RNA 76

Advarra

JUNE 13, 2023

Research in gene therapies and genetically engineered drugs and vaccines are growing exponentially, and will only continue to become more popular. This was just one of many questions we explore in our comprehensive survey of research sites and their internal activation practices.

Therapies 52

Therapies Research Clinical Trials Trials 52

Codon

APRIL 30, 2023

This study sheds light on how, exactly, AI-generated text differs from the real stuff, and how it could be used to (soon) write entire research papers. Read Ribosomes are able to build proteins because they contain a strand of RNA that imbues them with their catalytic power. Nucleic Acids Research. Nucleic Acids Research.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

This study sheds light on how, exactly, AI-generated text differs from the real stuff, and how it could be used to (soon) write entire research papers. Read Ribosomes are able to build proteins because they contain a strand of RNA that imbues them with their catalytic power. Nucleic Acids Research. Nucleic Acids Research.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

JUNE 26, 2023

Goodsell, Scripps Research and RCSB Protein Data Bank. I pulled them from a 2011 blog post ( oH mY goD tHat’S nOt pEEr-ReVieWeD!!! ” A blog post for the American Society for Microbiology : Early studies were promising, though experiments were often improperly designed by today's standards (i.e., Source 3 of 30.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

Goodsell, Scripps Research and RCSB Protein Data Bank. I pulled them from a 2011 blog post ( oH mY goD tHat’S nOt pEEr-ReVieWeD!!! ” A blog post for the American Society for Microbiology : Early studies were promising, though experiments were often improperly designed by today's standards (i.e., Source 3 of 30.

DNA 52

DNA Therapies Engineering Clinical Trials 52

PerkinElmer

OCTOBER 26, 2021

Since the World Health Organization (WHO) declared the novel coronavirus (COVID-19) outbreak a global pandemic on March 11, 2020, researchers around the world have been working tirelessly to discover effective preventive treatments and therapeutic agents. mg/mL to 1 mg/mL) compared with a positive control (antibody inhibitor AC384).

Virus 52

Virus RNA Research Treatment 52

Codon

APRIL 9, 2023

This is Codon Digest, my weekly roundup of research, news, and industry highlights about the future of biology. Small snippets of double-stranded RNA were sprayed onto hot pepper plants to control a pest, called Frankliniella occidentalis. The RNA strands shut down a specific gene in the insects, and killed half after 7 days.

Therapies 52

Therapies RNA Engineering Vaccine 52

The Open Targets Blog

APRIL 5, 2023

Emmanouil Metzakopian is a group leader at the UK Dementia Research Institute at the University of Cambridge, as well as VP of Research and Development at bit.bio. We then designed our own CRISPR guide RNA library against the druggable genome and transduced the corresponding lentiviruses into millions of our iNeurons.

Small Molecule 52

Small Molecule Disease RNA Treatment 52

Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. Nucleic Acids Research. coli and yeast), signed an agreement with the nonprofit, ATCC , to help get their microbes to researchers. Stahl et al.

Vaccine 52

Vaccine DNA Virus Engineering 52

Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. Nucleic Acids Research. coli and yeast), signed an agreement with the nonprofit, ATCC , to help get their microbes to researchers. Stahl et al.

Vaccine 52

Vaccine DNA Virus Engineering 52

PerkinElmer

JUNE 14, 2021

The speed at which researchers developed effective vaccines to prevent the spread of COVID-19 required unprecedented international cooperation on a scale never seen before. Meanwhile, researchers are continuing to investigate possible treatments for patients suffering with the disease. For research use only. Kirschner, L.,

Virus 52

Virus Vaccine RNA Treatment 52

PerkinElmer

AUGUST 18, 2020

For this reason, it might be necessary for research teams to screen many potential leads before they find one or two with strong potential. The time sensitivity of virus research, combined with an increasing complexity of bench tasks, can make it helpful for labs to increase automaticity of experiments. – [link] Wen et al.

Virus 52

Virus Vaccine RNA DNA 52

Codon

JULY 11, 2023

All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein. It moves along RNA and reads three letters at a time, called codons, to build the amino acid sequence of a protein. Blueprints The first step is to build a loop of RNA that encodes all the different codons.

RNA 75

RNA DNA Engineering Laboratories 75

Codon

SEPTEMBER 29, 2024

But, regardless of which was first, they all operated with the same core data as their mechanism for understanding life: messenger RNA ( mRNA ). The lab created a plan with eight research institutions across three continents. Models of life became the dominant research paradigm in nearly every life-sciences field.

Engineering 144

Engineering Virus DNA Therapies 144