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Plasmids 101: Expressing shRNAs for RNA Interference

addgene Blog

In the research world, there is a myriad of tools this could be applied to. However, RNA interference (RNAi) remains steadfast in the background, a handy “oldie” as you might say. An oldie but a goodie — a phrase used to refer to something that has fallen out of fashion but is still useful and most importantly, effective.

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Case study: gget’s new Open Target module

The Open Targets Blog

This blog post is part of a series that will explore applications and expansions of the Open Targets informatics ecosystem, particularly the Open Targets Platform and Open Targets Genetics through conversations with our users. The gget opentargets module plays a key role in enabling researchers to interpret the identified variants.

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Twist Bioscience

Human Comprehensive Exome Human Core Exome Human Methylome Panel Human RefSeq Panel Mitochondrial Panel Mouse Exome Panel Respiratory Virus Research Panel Comprehensive Viral Research Panel Twist's Whole Exome Library Preparation Workflow.

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Reaching cruising altitude: New discovery tools to target RNA

Dark Matter Blog

However, since most small molecule drugs target proteins in the cell, the vast majority of target identification methods available to research scientists are aimed at identifying interactions between small molecules and proteins. First, given an RNA target, could we identify where on the RNA an rSM bound?

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Fearlessly Forward to our Destination

Dark Matter Blog

We are moving rapidly toward escape velocity in our RNA expedition at Arrakis. We want to mark this progress with some updates and perspectives in the Dark Matter blog. Moreover, there is an even vaster universe of biology contained in non-coding transcripts that can only be reached by directly targeting RNA.

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BioDAOs are Community-Owned Research Translation Engines, Not Investment DAOs

Molecule Blog

Moving research from concept to market is like conducting a symphony — there are numerous players and stakeholders, each bringing their unique expertise to work in harmony and advance a project. BioDAOs fund and incubate projects during the initial stages of translational research, often through IP-NFTs, even before a company is established.

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A Look Back

Dark Matter Blog

As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. Growing up in Shrewsbury, Massachusetts, it was natural for me to attempt to get a summer job up the road at the Worcester Foundation for Biomedical Research, where the first oral contraceptive was created. I wanted to use molecular biology to create drugs.