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Levers for Biological Progress

Codon

Molecular biology has only been around for about 80 years, and tools to study biomolecules (such as DNA and RNA sequencing, or proteomics) have only existed for about half of that time. We are in the absolute infancy of molecular and cell biology, and this means there’s a lot of stuff we still don’t understand.

DNA 132
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First Patient Dosed in Monalizumab Phase 3 Clinical Trial Triggers $50M Payment From AstraZeneca

The Pharma Data

AstraZeneca will book all sales revenue and will pay Innate low double-digit to mid-teen percentage royalties on net sales worldwide except in Europe where Innate Pharma will receive 50% share of the profits and losses in the territory.

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Discovering an Antimalarial Drug in Mao’s China

Codon

When her father gave Tu the name “Youyou,” he started with characters from the Chinese classic Book of Odes: “The deer bleat: ‘yōu yōu’ while eating wild ‘hāo’” (呦呦鹿鸣,食野之蒿). falciparum. Nobody had an answer.

Drugs 141
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Biology is a Burrito

Codon

I felt like a scientist for the first time, and I began to grasp the “numbers of biology” (many calculations in this essay come from that course and another textbook, Cell Biology by the Numbers.) Without mathematics, I learned, biology is naked; we can only comprehend it at arm's length.

RNA 52
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Fast Biology

Codon

I first encountered Von Baer’s thought experiment in Richard Fisher’s book, The Long View. Credit: Rob Phillips and Ron Milo, Cell Biology by the Numbers. The Millennium Man’s experience would be the opposite; our world would feel impossibly quick. ” I share Fisher’s views on the Millenium Man.

RNA 98
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What Limits a Genome’s Size?

Codon

Credit: Oriane Hidalgo Per the book Cell Biology by the Numbers , each base pair of DNA occupies 1 nm 3 of space. So it was with some incredulity that I sat down, pulled out a scratch piece of paper, and jotted down some estimates.

DNA 63
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Neurobiology & Organismal Biology

Broad Institute

Dr. Hartmann has published over 40 research articles, reviews and book chapters. Here we propose to uncover the cell-type specific transcriptional pathways governed by cortisol levels in the frontal cortex, which comprises brain areas that are determinants of high-level cognition and mood, and therefore relevant to the symptomology of PTSD.